Single-Step Fabrication of High-Throughput Surface-Enhanced Raman Scattering Substrates

2018 ◽  
Vol 10 (4) ◽  
pp. 4222-4232 ◽  
Author(s):  
Yi Zeng ◽  
Xin Du ◽  
Bingbing Gao ◽  
Bing Liu ◽  
Zhuoying Xie ◽  
...  
Keyword(s):  
Raman Scattering ◽  
High Throughput ◽  
Surface Enhanced Raman Scattering ◽  
Single Step ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering

scholarly journals Improved Surface-Enhanced-Raman Scattering Sensitivity Using Si Nanowires/Silver Nanostructures by a Single Step Metal-Assisted Chemical Etching

Nanomaterials ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 1760
Author(s):  
Ioannis Kochylas ◽  
Spiros Gardelis ◽  
Vlassis Likodimos ◽  
Konstantinos Giannakopoulos ◽  
Polycarpos Falaras ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Raman Scattering ◽  
Chemical Etching ◽  
Surface Enhanced Raman Scattering ◽  
Single Step ◽  
Silver Nanostructures ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering ◽  
Metal Assisted Chemical Etching

In this study, we developed highly sensitive substrates for Surface-Enhanced-Raman-Scattering (SERS) spectroscopy, consisting of silicon nanowires (SiNWs) decorated by silver nanostructures using single-step Metal Assisted Chemical Etching (MACE). One-step MACE was performed on p-type Si substrates by immersion in AgNO3/HF aqueous solutions resulting in the formation of SiNWs decorated by either silver aggregates or dendrites. Specifically, dendrites were formed during SiNWs’ growth in the etchant solution, whereas aggregates were grown after the removal of the dendrites from the SiNWs in HNO3 aqueous solution and subsequent re-immersion of the specimens in a AgNO3/HF aqueous solution by adjusting the growth time to achieve the desired density of silver nanostructures. The dendrites had much larger height than the aggregates. R6G was used as analyte to test the SERS activity of the substrates prepared by the two fabrication processes. The silver aggregates showed a considerably lower limit of detection (LOD) for SERS down to a R6G concentration of 10−13 M, and much better uniformity in terms of detection in comparison with the silver dendritic structures. Enhancement factors in the range 105–1010 were calculated, demonstrating very high SERS sensitivities for analytic applications.

scholarly journals Surface-enhanced Raman scattering of CoV-SARS-2 viral proteins in a strong coupling regime

2021 ◽  
Vol 2058 (1) ◽  
pp. 012020
Author(s):  
K Mochalov ◽  
P Samokhvalov ◽  
G Nifontova ◽  
T Tsoi ◽  
A Sukhanova ◽  
...  
Keyword(s):  
Raman Scattering ◽  
High Throughput ◽  
Surface Enhanced Raman Scattering ◽  
Small Sample ◽  
Optical Methods ◽  
Strong Coupling Regime ◽  
Protein Film ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering

Abstract Fast, sensitive, high-throughput detection of coronavirus antigens at physiologically relevant levels is essential for population screening that could prevent epidemics such as the current COVID-19 global pandemic. Optical methods based on surface-enhanced Raman scattering (SERS) spectroscopy are promising for this purpose because they ensure quick detection of even single biological molecules in a sample. For achieving such a high sensitivity, it is crucial to design SERS-active systems concentrating incident radiation into small sample volumes. Here, metal-dielectric cavities have been obtained through interaction of protein sulfhydryl groups with a SERS-active silver surface. The concentration of light in these cavities allows the differential detection of spike glycoprotein and nucleocapsid protein of SARS-COV-2, which are its key antigens, at physiologically relevant concentrations. The cavity Q-factor can be increased by additionally covering the dielectric protein film with a silver shell to form an ultrathin cavity, which provides an at least tenfold enhancement of the detection signal. The results could be used to design high-throughput systems for specific and sensitive detection of viral antigens and quick diagnosis of viral infections.

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