Core–Shell Silver Nanoparticles in Endodontic Disinfection Solutions Enable Long-Term Antimicrobial Effect on Oral Biofilms

2017 ◽  
Vol 9 (40) ◽  
pp. 34762-34772 ◽  
Author(s):  
Elif Ertem ◽  
Beatrice Gutt ◽  
Flavia Zuber ◽  
Sergio Allegri ◽  
Benjamin Le Ouay ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Antimicrobial Effect ◽  
Core Shell ◽  
Oral Biofilms

Long-Term Antimicrobial Effect of Silicon Nanowires Decorated with Silver Nanoparticles

2010 ◽  
Vol 22 (48) ◽  
pp. 5463-5467 ◽  
Author(s):  
Min Lv ◽  
Shao Su ◽  
Yao He ◽  
Qing Huang ◽  
Wenbing Hu ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Silicon Nanowires ◽  
Antimicrobial Effect

scholarly journals Silver Nanoparticles in Dental Biomaterials

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Juliana Mattos Corrêa ◽  
Matsuyoshi Mori ◽  
Heloísa Lajas Sanches ◽  
Adriana Dibo da Cruz ◽  
Edgard Poiate ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Silver Nanoparticles ◽  
Silver Nanoparticle ◽  
Biofilm Formation ◽  
Dental Materials ◽  
Antimicrobial Properties ◽  
Antimicrobial Effect ◽  
Filler Level ◽  
Over Time

Silver has been used in medicine for centuries because of its antimicrobial properties. More recently, silver nanoparticles have been synthesized and incorporated into several biomaterials, since their small size provides great antimicrobial effect, at low filler level. Hence, these nanoparticles have been applied in dentistry, in order to prevent or reduce biofilm formation over dental materials surfaces. This review aims to discuss the current progress in this field, highlighting aspects regarding silver nanoparticles incorporation, such as antimicrobial potential, mechanical properties, cytotoxicity, and long-term effectiveness. We also emphasize the need for more studies to determine the optimal concentration of silver nanoparticle and its release over time.

Dual-effect core–shell polyphenol coated silver nanoparticles for tissue engineering

2021 ◽  
Vol 26 ◽  
pp. 100716
Author(s):  
Juan Manuel Galdopórpora ◽  
Angelina Ibar ◽  
Maria Victoria Tuttolomondo ◽  
Martin Federico Desimone
Keyword(s):  
Tissue Engineering ◽  
Silver Nanoparticles ◽  
Core Shell ◽  
Dual Effect

scholarly journals Single-Step Green Synthesis of Highly Concentrated and Stable Colloidal Dispersion of Core-Shell Silver Nanoparticles and Their Antimicrobial and Ultra-High Catalytic Properties

Nanomaterials ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 1007
Author(s):  
Azam Ali ◽  
Mariyam Sattar ◽  
Fiaz Hussain ◽  
Muhammad Humble Khalid Tareen ◽  
Jiri Militky ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Green Synthesis ◽  
Tannic Acid ◽  
Rate Constant ◽  
Catalytic Properties ◽  
Colloidal Dispersion ◽  
Alkaline Condition ◽  
Core Shell ◽  
Average Particle ◽  
Ag Nps

The versatile one-pot green synthesis of a highly concentrated and stable colloidal dispersion of silver nanoparticles (Ag NPs) was carried out using the self-assembled tannic acid without using any other hazardous chemicals. Tannic acid (Plant-based polyphenol) was used as a reducing and stabilizing agent for silver nitrate in a mild alkaline condition. The synthesized Ag NPs were characterized for their concentration, capping, size distribution, and shape. The experimental results confirmed the successful synthesis of nearly spherical and highly concentrated (2281 ppm) Ag NPs, capped with poly-tannic acid (Ag NPs-PTA). The average particle size of Ag NPs-PTA was found to be 9.90 ± 1.60 nm. The colloidal dispersion of synthesized nanoparticles was observed to be stable for more than 15 months in the ambient environment (25 °C, 65% relative humidity). The synthesized AgNPs-PTA showed an effective antimicrobial activity against Staphylococcus Aureus (ZOI 3.0 mM) and Escherichia coli (ZOI 3.5 mM). Ag NPs-PTA also exhibited enhanced catalytic properties. It reduces 4-nitrophenol into 4-aminophenol in the presence of NaBH4 with a normalized rate constant (Knor = K/m) of 615.04 mL·s−1·mg−1. For comparison, bare Ag NPs show catalytic activity with a normalized rate constant of 139.78 mL·s−1·mg−1. Furthermore, AgNPs-PTA were stable for more than 15 months under ambient conditions. The ultra-high catalytic and good antimicrobial properties can be attributed to the fine size and good aqueous stability of Ag NPs-PTA. The unique core-shell structure and ease of synthesis render the synthesized nanoparticles superior to others, with potential for large-scale applications, especially in the field of catalysis and medical.

scholarly journals Effect of silver nanoparticles on human mesenchymal stem cell differentiation

2014 ◽  
Vol 5 ◽  
pp. 2058-2069 ◽  
Author(s):  
Christina Sengstock ◽  
Jörg Diendorf ◽  
Matthias Epple ◽  
Thomas A Schildhauer ◽  
Manfred Köller
Keyword(s):  
Silver Nanoparticles ◽  
Cell Differentiation ◽  
Osteogenic Differentiation ◽  
Stem Cell Differentiation ◽  
Laser Scanning Microscopy ◽  
Surgical Instruments ◽  
Dependent Manner ◽  
Low Concentration ◽  
Long Term Treatment

Background: Silver nanoparticles (Ag-NP) are one of the fastest growing products in nano-medicine due to their enhanced antibacterial activity at the nanoscale level. In biomedicine, hundreds of products have been coated with Ag-NP. For example, various medical devices include silver, such as surgical instruments, bone implants and wound dressings. After the degradation of these materials, or depending on the coating technique, silver in nanoparticle or ion form can be released and may come into close contact with tissues and cells. Despite incorporation of Ag-NP as an antibacterial agent in different products, the toxicological and biological effects of silver in the human body after long-term and low-concentration exposure are not well understood. In the current study, we investigated the effects of both ionic and nanoparticulate silver on the differentiation of human mesenchymal stem cells (hMSCs) into adipogenic, osteogenic and chondrogenic lineages and on the secretion of the respective differentiation markers adiponectin, osteocalcin and aggrecan. Results: As shown through laser scanning microscopy, Ag-NP with a size of 80 nm (hydrodynamic diameter) were taken up into hMSCs as nanoparticulate material. After 24 h of incubation, these Ag-NP were mainly found in the endo-lysosomal cell compartment as agglomerated material. Cytotoxicity was observed for differentiated or undifferentiated hMSCs treated with high silver concentrations (≥20 µg·mL−1 Ag-NP; ≥1.5 µg·mL−1 Ag+ ions) but not with low-concentration treatments (≤10 µg·mL−1 Ag-NP; ≤1.0 µg·mL−1 Ag+ ions). Subtoxic concentrations of Ag-NP and Ag+ ions impaired the adipogenic and osteogenic differentiation of hMSCs in a concentration-dependent manner, whereas chondrogenic differentiation was unaffected after 21 d of incubation. In contrast to aggrecan, the inhibitory effect of adipogenic and osteogenic differentiation was confirmed by a decrease in the secretion of specific biomarkers, including adiponectin (adipocytes) and osteocalcin (osteoblasts). Conclusion: Aside from the well-studied antibacterial effect of silver, little is known about the influence of nano-silver on cell differentiation processes. Our results demonstrate that ionic or nanoparticulate silver attenuates the adipogenic and osteogenic differentiation of hMSCs even at non-toxic concentrations. Therefore, more studies are needed to investigate the effects of silver species on cells at low concentrations during long-term treatment.

scholarly journals Developmental exposure to silver nanoparticles leads to long term gut dysbiosis and neurobehavioral alterations

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Zhen Lyu ◽  
Shreya Ghoshdastidar ◽  
Karamkolly R. Rekha ◽  
Dhananjay Suresh ◽  
Jiude Mao ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Body Fat ◽  
Repetitive Behaviors ◽  
Developmental Exposure ◽  
Male And Female ◽  
Female Mice ◽  
Gut Dysbiosis ◽  
Study Results ◽  
Wide Range

AbstractDue to their antimicrobial properties, silver nanoparticles (AgNPs) are used in a wide range of consumer products that includes topical wound dressings, coatings for biomedical devices, and food-packaging to extend the shelf-life. Despite their beneficial antimicrobial effects, developmental exposure to such AgNPs may lead to gut dysbiosis and long-term health consequences in exposed offspring. AgNPs can cross the placenta and blood–brain-barrier to translocate in the brain of offspring. The underlying hypothesis tested in the current study was that developmental exposure of male and female mice to AgNPs disrupts the microbiome–gut–brain axis. To examine for such effects, C57BL6 female mice were exposed orally to AgNPs at a dose of 3 mg/kg BW or vehicle control 2 weeks prior to breeding and throughout gestation. Male and female offspring were tested in various mazes that measure different behavioral domains, and the gut microbial profiles were surveyed from 30 through 120 days of age. Our study results suggest that developmental exposure results in increased likelihood of engaging in repetitive behaviors and reductions in resident microglial cells. Echo-MRI results indicate increased body fat in offspring exposed to AgNPs exhibit. Coprobacillus spp., Mucispirillum spp., and Bifidobacterium spp. were reduced, while Prevotella spp., Bacillus spp., Planococcaceae, Staphylococcus spp., Enterococcus spp., and Ruminococcus spp. were increased in those developmentally exposed to NPs. These bacterial changes were linked to behavioral and metabolic alterations. In conclusion, developmental exposure of AgNPs results in long term gut dysbiosis, body fat increase and neurobehavioral alterations in offspring.

Effects of long-term oral administration of silver nanoparticles on the cognitive functions of mammals

2021 ◽  
Vol 29 (6) ◽  
pp. 33-38
Author(s):  
Anna Alexandrovna Antsiferova ◽  
Marina Yurievna Kopaeva ◽  
Vyacheslav Nikolaevich Kochkin ◽  
Pavel Konstantinovich Kashkarov
Keyword(s):  
Silver Nanoparticles ◽  
Oral Administration ◽  
Dietary Supplement ◽  
Cognitive Functions ◽  
High Demand ◽  
Gastrointestinal Infections ◽  
Impaired Cognitive Function ◽  
Potential Risks ◽  
The Brain

Introduction. Since the beginning of the XXI century, silver nanoparticles have been widely used in various industries, medicine and pharmaceuticals due to their pronounced antibacterial, antiviral and fungicidal properties. In connection with such a high demand for the use of silver nanoparticles, it is very important to understand the associated potential risks from their use. Materials and methods. In the course of the work, there has been a study of the effects of the long-term oral administration of a commercially produced dietary supplement based on silver nanoparticles with a size of 34 nm and stabilized with polyvinylpyrrolidone in an amount of 50 μg/day/animal on the cognitive functions of C57Bl/6 mice, as well as their accumulation in the brain by the method of instrumental neutron activation analysis. The dietary supplement used is recommended for people as a treatment for gastrointestinal infections. Results. It was found that after 180 days of administration, silver nanoparticles impair long-term contextual memory, and over time, the content of silver in the brain increases. Conclusion. Presumably impaired cognitive function with accumulation of silver in the brains of mice. This poses the risk of prolonged oral use of the silver nanoparticles.

Biodistribution and long-term fate of silver nanoparticles functionalized with bovine serum albumin in rats

Metallomics ◽  
2010 ◽  
Vol 2 (3) ◽  
pp. 204-210 ◽  
Author(s):  
Lourdes Garza-Ocañas ◽  
Domingo A. Ferrer ◽  
Justin Burt ◽  
Luis A. Diaz-Torres ◽  
Mónica Ramírez Cabrera ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum

Long-Term Antibacterial Coatings with Core–Shell Ag@SiO2 Colloid

2018 ◽  
Vol 18 (11) ◽  
pp. 7767-7774 ◽  
Author(s):  
Kai Wu ◽  
Shuang Zhang ◽  
Suxuan Lin ◽  
Jie-Xin Wang ◽  
Yuan Le
Keyword(s):  
Core Shell ◽  
Antibacterial Coatings
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