Sequential Delivery of Doxorubicin and Zoledronic Acid to Breast Cancer Cells by CB[7]-Modified Iron Oxide Nanoparticles

2017 ◽  
Vol 9 (46) ◽  
pp. 40006-40016 ◽  
Author(s):  
Farah Benyettou ◽  
Marwa Alhashimi ◽  
Matthew O’Connor ◽  
Renu Pasricha ◽  
Jeremy Brandel ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Iron Oxide ◽  
Zoledronic Acid ◽  
Cancer Cells ◽  
Iron Oxide Nanoparticles ◽  
Breast Cancer Cells ◽  
Oxide Nanoparticles

Polymer Coated Iron Nanoparticles: Radiolabeling & In Vitro Studies

2020 ◽  
Vol 13 ◽  
Author(s):  
Selin Yılmaz ◽  
Çiğdem İçhedef ◽  
Kadriye Buşra Karatay ◽  
Serap Teksöz
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Iron Oxide ◽  
Cancer Cells ◽  
Iron Oxide Nanoparticles ◽  
Breast Cancer Cells ◽  
Cancer Drug ◽  
Oxide Nanoparticles ◽  
Sem Images

Backgorund: Superparamagnetic iron oxide nanoparticles (SPIONs) have been extensively used for targeted drug delivery systems due to their unique magnetic properties. Objective: In this study, it’s aimed to develop a novel targeted 99mTc radiolabeled polymeric drug delivery system for Gemcitabine (GEM). Methods: Gemcitabine, an anticancer agent, was encapsulated into polymer nanoparticles (PLGA) together with iron oxide nanoparticles via double emulsion technique and then labeled with 99mTc. SPIONs were synthesized by reduction–coprecipitation method and encapsulated with oleic acid for surface modification. Size distribution and the morphology of the synthesized nanoparticles were caharacterized by dynamic light scattering(DLS)and scanning electron microscopy(SEM), respectively. Radiolabeling yield of SPION-PLGAGEM nanoparticles were determined via Thin Layer Radio Chromatography (TLRC). Cytotoxicity of GEM loaded SPION-PLGA were investigated on MDA-MB-231 and MCF7 breast cancer cells in vitro. Results: SEM images displayed that the average size of the drug-free nanoparticles was 40 nm and the size of the drug-loaded nanoparticles was 50 nm. The diameter of nanoparticles were determined as 366.6 nm by DLS, while zeta potential was found as-29 mV. SPION was successfully coated with PLGA, which was confirmed by FTIR. GEM encapsulation efficiency of SPION-PLGA was calculated as 4±0.16 % by means of HPLC. Radiolabeling yield of SPION-PLGA-GEM nanoparticles were determined as 97.8±1.75 % via TLRC. Cytotoxicity of GEM loaded SPION-PLGA were investigated on MDA-MB-231 and MCF7 breast cancer cells. SPION-PLGA-GEM showed high uptake on MCF-7, whilst incorporation rate was increased for both cell lines which external magnetic field application. Conclusion: 99mTc labeled SPION-PLGA nanoparticles loaded with GEM may overcome some of the obstacles in anti-cancer drug delivery because of their appropriate size, non-toxic, and supermagnetic characteristics.

scholarly journals Synthesis, Characterization, and Cytotoxicity of Iron Oxide Nanoparticles

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
S. Kanagesan ◽  
M. Hashim ◽  
S. Tamilselvan ◽  
N. B. Alitheen ◽  
I. Ismail ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Iron Oxide ◽  
Cancer Cells ◽  
Iron Oxide Nanoparticles ◽  
Human Breast Cancer ◽  
Cellular Response ◽  
Breast Cancer Cells ◽  
Oxide Nanoparticles ◽  
Human Breast Cancer Cells ◽  
Human Breast

In order to study the response of human breast cancer cells' exposure to nanoparticle, iron oxide (α-Fe2O3) nanoparticles were synthesized by a simple low temperature combustion method using Fe(NO3)3·9H2O as raw material. X-ray diffraction studies confirmed that the resultant powders are pureα-Fe2O3. Transmission electron microscopy study revealed the spherical shape of the primary particles, and the size of the iron oxide nanoparticles is in the range of 19 nm. The magnetic hysteresis loops demonstrated that the sample exposed ferromagnetic behaviors with a relatively low coercivity. The cytotoxicity ofα-Fe2O3nanoparticle was also evaluated on human breast cancer cells to address the current deficient knowledge of cellular response to nanoparticle exposure.

scholarly journals Anti-HER2/neu peptide-conjugated iron oxide nanoparticles for targeted delivery of paclitaxel to breast cancer cells

Nanoscale ◽  
2015 ◽  
Vol 7 (43) ◽  
pp. 18010-18014 ◽  
Author(s):  
Qingxin Mu ◽  
Forrest M. Kievit ◽  
Rajeev J. Kant ◽  
Guanyou Lin ◽  
Mike Jeon ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Iron Oxide ◽  
Cancer Cells ◽  
Iron Oxide Nanoparticles ◽  
Targeted Delivery ◽  
Breast Cancer Cells ◽  
Oxide Nanoparticles

scholarly journals Treatment of Breast Cancer-Bearing BALB/c Mice with Magnetic Hyperthermia using Dendrimer Functionalized Iron-Oxide Nanoparticles

Nanomaterials ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. 2310 ◽  
Author(s):  
Marzieh Salimi ◽  
Saeed Sarkar ◽  
Mansoureh Hashemi ◽  
Reza Saber
Keyword(s):  
Breast Cancer ◽  
Iron Oxide ◽  
Cancer Cells ◽  
Iron Oxide Nanoparticles ◽  
Breast Cancer Cells ◽  
Metastatic Breast ◽  
B Cell Lymphoma ◽  
Magnetic Hyperthermia ◽  
Oxide Nanoparticles ◽  
Hyperthermia Treatment

The development of novel nanoparticles for diagnostic and therapeutic applications has been one of the most crucial challenges in cancer theranostics for the last decades. Herein, we functionalized iron oxide nanoparticles (IONPs) with the fourth generation (G4) of poly amidoamine (PAMAM) dendrimers (G4@IONPs) for magnetic hyperthermia treatment of breast cancer in Bagg albino strain C (BALB/c)mice. The survival of breast cancer cells significantly decreased after incubation with G4@IONPs and exposure to an alternating magnetic field (AMF) due to apoptosis and elevation of Bax (Bcl-2 associated X)/Bcl-2(B-cell lymphoma 2) ratio. After intratumoral injection of G4@IONPs, tumor-bearing BALB/c mice were exposed to AMF for 20 min; this procedure was repeated three times every other day. After the last treatment, tumor size was measured every three days. Histopathological and Immunohistochemical studies were performed on the liver, lung, and tumor tissues in treated and control mice. The results did not show any metastatic cells in the liver and lung tissues in the treatment group, while the control mice tissues contained metastatic breast cancer cells. Furthermore, the findings of the present study showed that magnetic hyperthermia treatment inhibited tumor growth by increasing cancer cell apoptosis, as well as reducing the tumor angiogenesis.

Detection and measurement of HER2+ breast cancer cells using tumor-targeted iron oxide nanoparticles and magnetic relaxometry.

2018 ◽  
Vol 36 (15_suppl) ◽  
pp. e13019-e13019
Author(s):  
Farideh Z. Bischoff ◽  
Kelsey Boitnott Mathieu ◽  
Lan Pang ◽  
Adam Kulp ◽  
Zhen Lu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Iron Oxide ◽  
Cancer Cells ◽  
Iron Oxide Nanoparticles ◽  
Breast Cancer Cells ◽  
Oxide Nanoparticles ◽  
Her2 Breast Cancer
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