Porous Iron-Carboxylate Metal–Organic Framework: A Novel Bioplatform with Sustained Antibacterial Efficacy and Nontoxicity

2017 ◽  
Vol 9 (22) ◽  
pp. 19248-19257 ◽  
Author(s):  
Sha Lin ◽  
Xiangmei Liu ◽  
Lei Tan ◽  
Zhenduo Cui ◽  
Xianjin Yang ◽  
...  
Keyword(s):  
Metal Organic Framework ◽  
Porous Iron ◽  
Antibacterial Efficacy ◽  
Metal Organic ◽  
Iron Carboxylate ◽  
Organic Framework

scholarly journals In Vitro Toxicity Study of a Porous Iron(III) Metal‒Organic Framework

Molecules ◽  
2019 ◽  
Vol 24 (7) ◽  
pp. 1211 ◽  
Author(s):  
Gongsen Chen ◽  
Xin Leng ◽  
Juyuan Luo ◽  
Longtai You ◽  
Changhai Qu ◽  
...  
Keyword(s):  
Metal Organic Framework ◽  
Drug Carrier ◽  
In Vitro Cytotoxicity ◽  
In Vitro Toxicity ◽  
Porous Iron ◽  
Dapi Staining ◽  
Toxicological Assessment ◽  
Metal Organic ◽  
Organic Framework

A MIL series metal‒organic framework (MOF), MIL-100(Fe), was successfully synthesized at the nanoscale and fully characterized by TEM, TGA, XRD, FTIR, DLS, and BET. A toxicological assessment was performed using two different cell lines: human normal liver cells (HL-7702) and hepatocellular carcinoma (HepG2). In vitro cytotoxicity of MIL-100(Fe) was evaluated by the MTT assay, LDH releasing rate assay, DAPI staining, and annexin V/PI double staining assay. The safe dose of MIL-100(Fe) was 80 μg/mL. It exhibited good biocompatibility, low cytotoxicity, and high cell survival rate (HL-7702 cells’ viability >85.97%, HepG2 cells’ viability >91.20%). Therefore, MIL-100(Fe) has a potential application as a drug carrier.

Guest Modulation of Spin-Crossover Transition Temperature in a Porous Iron(II) Metal-Organic Framework: Experimental and Periodic DFT Studies

2014 ◽  
Vol 20 (40) ◽  
pp. 12864-12873 ◽  
Author(s):  
Daniel Aravena ◽  
Zulema Arcís Castillo ◽  
M. Carmen Muñoz ◽  
Ana B. Gaspar ◽  
Ko Yoneda ◽  
...  
Keyword(s):  
Transition Temperature ◽  
Spin Crossover ◽  
Metal Organic Framework ◽  
Porous Iron ◽  
Dft Studies ◽  
Metal Organic ◽  
Crossover Transition ◽  
Periodic Dft ◽  
Organic Framework

Metal–organic-framework-supported immunostimulatory oligonucleotides for enhanced immune response and imaging

2017 ◽  
Vol 53 (11) ◽  
pp. 1840-1843 ◽  
Author(s):  
Yan Zhang ◽  
Chaoqun Liu ◽  
Faming Wang ◽  
Zhen Liu ◽  
Jinsong Ren ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Immune Response ◽  
Magnetic Resonance ◽  
Metal Organic Framework ◽  
Metal Organic Frameworks ◽  
Resonance Imaging ◽  
Cpg Odns ◽  
Metal Organic ◽  
Iron Carboxylate ◽  
Organic Framework

Iron carboxylate metal–organic frameworks supporting CpG ODNs were fabricated to enhance both the immune response of the CpG ODNs and the ability to image them using T2-magnetic resonance imaging.

scholarly journals Antibacterial efficacy from NO-releasing MOF–polymer films

2020 ◽  
Vol 1 (7) ◽  
pp. 2509-2519
Author(s):  
Morven J. Duncan ◽  
Paul S. Wheatley ◽  
Emma M. Coghill ◽  
Simon M. Vornholt ◽  
Stewart J. Warrender ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Polymer Films ◽  
Metal Organic Framework ◽  
Antibacterial Efficacy ◽  
Metal Organic ◽  
Sufficient Concentration ◽  
Organic Framework

Sufficient concentration of nitric oxide is released from metal organic framework loaded polymer films to impart antibacterial efficacy.

Influence of the Organic Ligand Functionalization on the Breathing of the Porous Iron Terephthalate Metal Organic Framework Type Material upon Hydrocarbon Adsorption

2011 ◽  
Vol 115 (38) ◽  
pp. 18683-18695 ◽  
Author(s):  
Naseem A. Ramsahye ◽  
Thuy Khuong Trung ◽  
Sandrine Bourrelly ◽  
Qingyuan Yang ◽  
Thomas Devic ◽  
...  
Keyword(s):  
Metal Organic Framework ◽  
Organic Ligand ◽  
Type Material ◽  
Porous Iron ◽  
Hydrocarbon Adsorption ◽  
Metal Organic ◽  
Organic Framework

Impact of phosphorylation on the encapsulation of nucleoside analogues within porous iron(iii) metal–organic framework MIL-100(Fe) nanoparticles

2013 ◽  
Vol 1 (34) ◽  
pp. 4231 ◽  
Author(s):  
Valentina Agostoni ◽  
Resmi Anand ◽  
Sandra Monti ◽  
Shaun Hall ◽  
Guillaume Maurin ◽  
...  
Keyword(s):  
Metal Organic Framework ◽  
Nucleoside Analogues ◽  
Porous Iron ◽  
Fe Nanoparticles ◽  
Metal Organic ◽  
Organic Framework

scholarly journals Metal-organic framework (MOF) nanomedicine preparations of sildenafil designed for the future treatment of pulmonary arterial hypertension

2019 ◽  
Author(s):  
Nura A. Mohamed ◽  
Haissam Abou Saleh ◽  
Yu Kameno ◽  
Isra Marei ◽  
Gilberto de Nucci ◽  
...  
Keyword(s):  
Pulmonary Arterial Hypertension ◽  
Drug Release ◽  
Arterial Hypertension ◽  
Metal Organic Framework ◽  
Porous Iron ◽  
Phosphodiesterase Type 5 Inhibitors ◽  
Metal Organic ◽  
Pulmonary Arterial ◽  
Nano Formulation ◽  
Organic Framework

AbstractPulmonary Arterial Hypertension (PAH) is an aggressive disease with poor prognosis, no available cure, and low survival rates. Currently, there are several classes of vasodilator drugs that are widely used as treatment strategies for PAH. These include (i) endothelin-1 receptor antagonists, (ii) phosphodiesterase type 5 inhibitors, (iii) prostacyclin analogues, and (iv) soluble guanylate cyclase activators. Despite their clinical benefits, these therapies are hindered by their systemic side effects. This limitation could be overcome by controlled drug release, with future modifications for targeted drug delivery, using a nanomedicine approach. In the current study, we have evaluated one particular nanomedicine platform (the highly porous iron-based metal-organic framework (MOF) commonly referred to as MIL-89) as a carrier of the PAH drug sildenafil. We have previously shown that MIL-89 is relatively non-toxic in a range of human cell types and well tolerated in vivo. Here we prepared a nano-formulation of MIL-89 (nanoMIL-89) and then successfully charged it with a payload of sildenafil (sil@nanoMIL-891). sil@nanoMIL-89 was then shown to release sildenafil in a biphasic manner with an initial rapid release over 6 hours followed by a more sustained release over 72 hours. Both nanoMIL-89 and sil@nanoMIL-89 were relatively non-toxic when incubated with human endothelial cells for 24 hours. Finally, the vasodilator effect of sil@nanoMIL-89 was measured over 8 hours using isolated mouse aorta. Consistent with drug release kinetics, sil@nanoMIL-89 induced vasodilation after a lag phase of >4 hours. Thus, in sil@nanoMIL-89, we have produced a nano-formulation of sildenafil displaying delayed drug release corresponding to vasodilator activity. Further pharmacological assessment of sil@nanoMIL-89, including in PAH models, is now required and constitutes the subject of ongoing investigation.

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