Ultrathin In2O3 Nanosheets with Uniform Mesopores for Highly Sensitive Nitric Oxide Detection

2017 ◽  
Vol 9 (19) ◽  
pp. 16335-16342 ◽  
Author(s):  
Xue Wang ◽  
Juan Su ◽  
Hui Chen ◽  
Guo-Dong Li ◽  
Zhifang Shi ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Highly Sensitive ◽  
Uniform Mesopores

NO, CO and H2S based pharmaceuticals in the mission of vision (eye health): a comprehensive review

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Jan Mohammad Mir ◽  
Ram Charitra Maurya ◽  
Mohd Washid Khan
Keyword(s):  
Nitric Oxide ◽  
Carbon Monoxide ◽  
Human Physiology ◽  
Hydrogen Sulfide ◽  
The Other ◽  
Normal Functioning ◽  
Comprehensive Review ◽  
Molecular Systems ◽  
Eye Health ◽  
Highly Sensitive

Abstract A set of well defined signaling molecules responsible for normal functioning of human physiology including nitric oxide along with carbon monoxide and hydrogen sulphide are referred as “gasotransmitters”. Due to their involvement in almost every system of a human body, the care of highly sensitive organs using these molecules as drugs represents highly fascinating area of research. In connection with these interesting aspects, the applied aspects of these gaseous molecules in maintaining healthy eye and vision have been targeted in this review. Several examples of eye-droppers including NORMs like latanoprost and nipradiol, CORMs like CORM-3 and CORM-A1, and Hydrogen sulfide releasing system like GYY4137 have been discussed in this context. Therefore the relation of these trio-gasotransmitters with the ophthalmic homeostasis on one hand, and de-infecting role on the other hand has been mainly highlighted. Some molecular systems capable of mimicking gasotransmitter action have also been introduced in connection with the titled theme.

Reduced Graphene Oxide Electrically Contacted Graphene Sensor for Highly Sensitive Nitric Oxide Detection

ACS Nano ◽  
2011 ◽  
Vol 5 (9) ◽  
pp. 6955-6961 ◽  
Author(s):  
Weiwei Li ◽  
Xiumei Geng ◽  
Yufen Guo ◽  
Jizan Rong ◽  
Youpin Gong ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Graphene Oxide ◽  
Reduced Graphene Oxide ◽  
Reduced Graphene ◽  
Highly Sensitive

The rational design of a highly sensitive and selective fluorogenic probe for detecting nitric oxide

2014 ◽  
Vol 50 (49) ◽  
pp. 6475-6478 ◽  
Author(s):  
Sufang Ma ◽  
De-Cai Fang ◽  
Baoming Ning ◽  
Minfeng Li ◽  
Lan He ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Small Molecule ◽  
Rational Design ◽  
Switching Mechanism ◽  
Fluorogenic Probe ◽  
Highly Sensitive

A small-molecule fluorogenic probe for nitric oxide (NO) detection based on a new switching mechanism is developedviaa rational design.

The Ability of Blood Plasma to Inhibit Catalase in the Presence of Chloride is a Highly Sensitive Indicator of Deposited Nitric Oxide and Leukocyte Activation

2020 ◽  
Vol 16 (2) ◽  
pp. 172-180
Author(s):  
Vladimir Titov ◽  
Anatoly Osipov ◽  
Anatoly Vanin
Keyword(s):  
Nitric Oxide ◽  
Blood Plasma ◽  
Inflammatory Diseases ◽  
Clinical Signs ◽  
Iron Complexes ◽  
Sensitive Indicator ◽  
Specific Method ◽  
Leukocyte Activation ◽  
Highly Sensitive ◽  
Nitrosyl Iron Complexes

Aims: To find out the origin of so-called nitrite - like substance (NLS) that appears in the blood plasma in patients with inflammatory diseases and the mechanism of its occurrence. To justify the possibility of registering its appearance in the blood as a highly sensitive indicator of leukocyte activation. Background: The need for a simple, sensitive and specific method of early diagnosis of inflammation, the key stage of which is the activation of white blood cells. Objective: To find out the origin of so-called nitrite - like substance (NLS) that appears in the blood plasma in patients with inflammatory diseases before the onset of clinical signs. This substance is able to inhibit catalase in the presence of chloride which is typical for nitrite and nitrosoamines. Methods: The catalase activity was determined by the calorimetric method based on the control of the kinetics of heat production accompanying hydrogen peroxide decomposition. Results: Blood plasma contains deposited nitric oxide included in various nitrosyl iron complexes. These complexes effectively interact with the superoxide produced by activated leukocytes. This interaction produces a number of substances that have the ability to inhibit catalase in the presence of chloride. These substances retain the ability to inhibit in the system: hemoglobin-iron chelator, or hemoglobin-mercury salt. Such properties are characteristic of nitrite and nitrosoamines. Normally, these substances are present in plasma in trace amounts. 700 activated cells per microliter (10 times less than normal in human blood) are enough to transform about 30% nitrosyl iron complexes contained in plasma into NLS. Conclusion: The appearance of NLS is a very sensitive indicator of leukocyte activation.

Highly sensitive ratiometric fluorescence probes for nitric oxide based on dihydropyridine and potentially useful in bioimaging

RSC Advances ◽  
2016 ◽  
Vol 6 (114) ◽  
pp. 113219-113227 ◽  
Author(s):  
Ajit Kumar Mahapatra ◽  
Syed Samim Ali ◽  
Kalipada Maiti ◽  
Sanchita Mondal ◽  
Rajkishor Maji ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Fluorescence Probes ◽  
Ratiometric Fluorescence ◽  
Highly Sensitive

Hantzsch dihydropyridine-based ratiometric fluorescent NO probes, viz.PyNO and TPANO, were synthesized and characterized.

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