Polylactic Acid Nanofiber Scaffold Decorated with Chitosan Islandlike Topography for Bone Tissue Engineering

2017 ◽  
Vol 9 (25) ◽  
pp. 21094-21104 ◽  
Author(s):  
Ting Xu ◽  
Hongyang Yang ◽  
Dongzhi Yang ◽  
Zhong-Zhen Yu
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Polylactic Acid ◽  
Nanofiber Scaffold

scholarly journals Production, by co-grinding in a media mill, of porous biodegradable polylactic acid–apatite composite materials for bone tissue engineering

2009 ◽  
Vol 190 (1-2) ◽  
pp. 89-94 ◽  
Author(s):  
Nadine Le Bolay ◽  
Véronique Santran ◽  
Gérard Dechambre ◽  
Christèle Combes ◽  
Christophe Drouet ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Composite Materials ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Polylactic Acid

Polylactic acid–phosphate glass composite foams as scaffolds for bone tissue engineering

2007 ◽  
Vol 80B (2) ◽  
pp. 322-331 ◽  
Author(s):  
G. Georgiou ◽  
L. Mathieu ◽  
D. P. Pioletti ◽  
P.-E. Bourban ◽  
J.-A. E. Månson ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Polylactic Acid ◽  
Phosphate Glass ◽  
Glass Composite ◽  
Acid Phosphate ◽  
Composite Foams

scholarly journals Three-dimensional Printed Polylactic Acid and Hydroxyapatite Composite Scaffold with Urine-derived Stem Cells Treatment for Bone Defects

2021 ◽  
Author(s):  
Xiang Zhang ◽  
Jialei Chen ◽  
Hongren Wang ◽  
Xin Duan ◽  
Feng Gao
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Polylactic Acid ◽  
Composite Scaffold ◽  
Bone Defects ◽  
Skull Defect ◽  
Defect Area ◽  
3D Printed

Abstract BACKGROUND: Bone defects still pose various challenges in osteology. As one of the treatment options for bone defects, bone tissue engineering requires biomaterials with good biocompatibility and seed cells with good differentiation capacity. This study aimed to fabricate a 3D-printed polylactic acid and hydroxyapatite (PLA/HA) composite scaffold with urine-derived stem cells (USCs) to study its therapeutic effect in a model of skull defect in rats.METHODS: USCs, isolated and extracted from the urine of healthy adult males, were inoculated onto a 3D-printed PLA/HA composite scaffold and a PLA scaffold. Skull defect model rats were randomly divided into three groups (control, PLA, and PLA/HA). Twelve weeks after implanting scaffolds containing USCs into rats with a skull defect, the therapeutic efficacy was evaluated by real-time PCR, micro-CT, histology, and immunohistochemistry.RESULTS: The 3D-printed PLA/HA composite scaffold had good mechanical properties and porosity. The adhesion and proliferation of USCs on scaffolds also demonstrated excellent biocompatibility. PLA and PLA/HA containing USCs promoted bone regeneration in the defect area, supported by the general observation and CT images at 12 weeks after treatment, with coverage of 74.6%±1.9% and 96.7%±1.6%, respectively. Immunohistochemical staining showed a progressive process of new bone formation on PLA/HA scaffolds containing USCs at the defect site compared to that in PLA and control groups.CONCLUSION: The 3D-printed PLA/HA composite scaffold with USCs was successfully applied to the skull defect in rats. Under the linkage of the scaffold, the proliferation, differentiation, and osteogenesis expression of USCs were promoted near the bone defect area. These findings demonstrated broad application prospects of PLA/HA scaffolds with USCs in bone tissue engineering.

Polylactic acid fibre-reinforced polycaprolactone scaffolds for bone tissue engineering

Biomaterials ◽  
2008 ◽  
Vol 29 (27) ◽  
pp. 3662-3670 ◽  
Author(s):  
Vincenzo Guarino ◽  
Filippo Causa ◽  
Paola Taddei ◽  
Michele di Foggia ◽  
Gabriela Ciapetti ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Polylactic Acid

Bone tissue engineering potentials of 3D printed magnesium‐hydroxyapatite@polylactic acid composite scaffolds

2021 ◽  
Author(s):  
J. Anita Lett ◽  
Suresh Sagadevan ◽  
Estelle Léonard ◽  
Is Fatimah ◽  
M. A. Motalib Hossain ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Polylactic Acid ◽  
Composite Scaffolds ◽  
3D Printed
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