pH-Sensitive Reversible Programmed Targeting Strategy by the Self-Assembly/Disassembly of Gold Nanoparticles

2017 ◽  
Vol 9 (20) ◽  
pp. 16767-16777 ◽  
Author(s):  
Jinlong Ma ◽  
Zhenpeng Hu ◽  
Wei Wang ◽  
Xinyu Wang ◽  
Qiang Wu ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Self Assembly ◽  
Ph Sensitive ◽  
The Self ◽  
Targeting Strategy

Recovery and redispersion of gold nanoparticles using the self-assembly of a pH sensitive zwitterionic amphiphile

2014 ◽  
Vol 50 (85) ◽  
pp. 12933-12936 ◽  
Author(s):  
Clara Morita-Imura ◽  
Yoshiro Imura ◽  
Takeshi Kawai ◽  
Hitoshi Shindo
Keyword(s):  
Gold Nanoparticles ◽  
Self Assembly ◽  
Au Nanoparticles ◽  
Ph Sensitive ◽  
The Self ◽  
Ph Responsive

The pH-responsive self-assembly of a zwitterionic amphiphile was expanded to the recovery of gold (Au) nanoparticles. Multilayered lamellae were incorporated into the nanoparticles. Redispersion of nanoparticles was achieved by the transition of self-assembly based on pH.

scholarly journals Cylindrical Micelles by the Self-Assembly of Crystalline-b-Coil Polyphosphazene-b-P2VP Block Copolymers. Stabilization of Gold Nanoparticles

Molecules ◽  
2019 ◽  
Vol 24 (9) ◽  
pp. 1772 ◽  
Author(s):  
Maria de los Angeles Cortes ◽  
Raquel de la Campa ◽  
Maria Luisa Valenzuela ◽  
Carlos Díaz ◽  
Gabino A. Carriedo ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Block Copolymers ◽  
Self Assembly ◽  
Cationic Polymerization ◽  
The Self ◽  
The Novel ◽  
Selective Solvent ◽  
The Core ◽  
Cylindrical Micelles ◽  
Main Factor

During the last number of years a variety of crystallization-driven self-assembly (CDSA) processes based on semicrystalline block copolymers have been developed to prepare a number of different nanomorphologies in solution (micelles). We herein present a convenient synthetic methodology combining: (i) The anionic polymerization of 2-vinylpyridine initiated by organolithium functionalized phosphane initiators; (ii) the cationic polymerization of iminophosphoranes initiated by –PR2Cl2; and (iii) a macromolecular nucleophilic substitution step, to prepare the novel block copolymers poly(bistrifluoroethoxy phosphazene)-b-poly(2-vinylpyridine) (PTFEP-b-P2VP), having semicrystalline PTFEP core forming blocks. The self-assembly of these materials in mixtures of THF (tetrahydrofuran) and 2-propanol (selective solvent to P2VP), lead to a variety of cylindrical micelles of different lengths depending on the amount of 2-propanol added. We demonstrated that the crystallization of the PTFEP at the core of the micelles is the main factor controlling the self-assembly processes. The presence of pyridinyl moieties at the corona of the micelles was exploited to stabilize gold nanoparticles (AuNPs).

Stabilization of α-helices by the self-assembly of macrocyclic peptides on the surface of gold nanoparticles for molecular recognition

2013 ◽  
Vol 49 (69) ◽  
pp. 7617 ◽  
Author(s):  
Boram Kim ◽  
Sung-ju Choi ◽  
So-hee Han ◽  
Kang-Yell Choi ◽  
Yong-beom Lim
Keyword(s):  
Gold Nanoparticles ◽  
Molecular Recognition ◽  
Self Assembly ◽  
The Self ◽  
Macrocyclic Peptides

scholarly journals Application of Mesoscale Simulation to Explore the pH Response of Eudragit S100 Used as the Novel Colon-Targeted Powder of Pulsatilla Saponin D

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Mingcheng Gong ◽  
Zhenhua Chen ◽  
Liangliang Zhou ◽  
Feng Gao ◽  
Jianxin Cheng ◽  
...  
Keyword(s):  
Self Assembly ◽  
Morphological Changes ◽  
Drug Carrier ◽  
Dissipative Particle Dynamics ◽  
Ph Sensitive ◽  
The Self ◽  
Coarse Grained ◽  
Release Mechanism ◽  
Eudragit S100 ◽  
Ph Conditions

As a pH-sensitive nanomaterial, Eudragit S100 has good colon targeting. However, little research has been carried out on its mesoscopic scale. In this paper, the self-assembly behavior of Pulsatilla saponins D (PSD) and Eudragit S100, as well as the loading and release mechanism of PSD, was investigated via computer simulations. The effects of the self-assembly characteristics of PSD and Eudragit S100 in the dry powder state on the drug-carrier ratio were explored by the coarse-grained molecular dynamics (CGMD) method. According to the pH-responsive feature of Eudragit S100, the drug protection under gastric pH conditions and release in colonic pH conditions were simulated through the dissipative particle dynamics (DPD) method, which has provided insights into the microscopic morphological changes in the pH-sensitive drug delivery systems.

An IR modulator based on the self-assembly of gold nanoparticles on germanium

2014 ◽  
Vol 16 (36) ◽  
pp. 19402-19407 ◽  
Author(s):  
Harekrishna Ghosh ◽  
Ahmed Bouhekka ◽  
Thomas Bürgi
Keyword(s):  
Gold Nanoparticles ◽  
Valence Band ◽  
Self Assembly ◽  
Near Infrared ◽  
The Self ◽  
Band Edge ◽  
Infrared Light ◽  
Valence Band Edge ◽  
Near Infrared Light

Germanium modified with gold nanoparticles shows a drastically increased concentration of holes near the valence band edge upon illumination with visible or near infrared light.

scholarly journals Gold nanoparticles covalently assembled onto vesicle structures as possible biosensing platform

2016 ◽  
Vol 7 ◽  
pp. 655-663 ◽  
Author(s):  
M Fátima Barroso ◽  
M Alejandra Luna ◽  
Juan S Flores Tabares ◽  
Cristina Delerue-Matos ◽  
N Mariano Correa ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Self Assembly ◽  
Environmentally Friendly ◽  
Spherical Shape ◽  
The Self ◽  
Large Unilamellar Vesicle ◽  
Future Design ◽  
Pure Glycerol ◽  
The Future ◽  
Microscopy Techniques

In this contribution a strategy is shown to covalently immobilize gold nanoparticles (AuNPs) onto vesicle bilayers with the aim of using this nanomaterial as platform for the future design of immunosensors. A novel methodology for the self-assembly of AuNPs onto large unilamellar vesicle structures is described. The vesicles were formed with 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) and 1-undecanethiol (SH). After, the AuNPs photochemically synthesized in pure glycerol were mixed and anchored onto SH–DOPC vesicles. The data provided by voltammetry, spectrometry and microscopy techniques indicated that the AuNPs were successfully covalently anchored onto the vesicle bilayer and decorated vesicles exhibit a spherical shape with a size of 190 ± 10 nm. The developed procedure is easy, rapid and reproducible to start designing a possible immunosensor by using environmentally friendly procedures.

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