Cell Adhesion Induced Using Surface Modification with Cell-Penetrating Peptide-Conjugated Poly(ethylene glycol)-Lipid: A New Cell Glue for 3D Cell-Based Structures

2016 ◽  
Vol 9 (1) ◽  
pp. 244-254 ◽  
Author(s):  
Yuji Teramura ◽  
Sana Asif ◽  
Kristina N. Ekdahl ◽  
Elisabet Gustafson ◽  
Bo Nilsson
Keyword(s):  
Surface Modification ◽  
Cell Adhesion ◽  
Ethylene Glycol ◽  
Lipid A ◽  
Cell Penetrating Peptide ◽  
Poly Ethylene Glycol ◽  
Cell Penetrating ◽  
Poly Ethylene

scholarly journals Methoxy-Poly(ethylene glycol) Modified Poly(L-lactide) Enhanced Cell Affinity of Human Bone Marrow Stromal Cells by the Upregulation of 1-Cadherin and Delta-2-catenin

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Xueli Mao ◽  
Zetao Chen ◽  
Junqi Ling ◽  
Jingjing Quan ◽  
Hui Peng ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Cell Adhesion ◽  
Ethylene Glycol ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Marrow Stromal Cells ◽  
Poly Ethylene Glycol ◽  
Copolymer Films ◽  
Cell Affinity ◽  
Poly Ethylene

Poly(l-lactide) (PLLA), a versatile biodegradable polymer, is one of the most commonly-used materials for tissue engineering applications. To improve cell affinity for PLLA, poly(ethylene glycol) (PEG) was used to develop diblock copolymers. Human bone marrow stromal cells (hBMSCs) were cultured on MPEG-b-PLLA copolymer films to determine the effects of modification on the attachment and proliferation of hBMSC. The mRNA expression of 84 human extracellular matrix (ECM) and adhesion molecules was analyzed using RT-qPCR to understand the underlying mechanisms. It was found that MPEG-b-PLLA copolymer films significantly improved cell adhesion, extension, and proliferation. This was found to be related to the significant upregulation of two adhesion genes, CDH1 and CTNND2, which encode 1-cadherin and delta-2-catenin, respectively, two key components for the cadherin-catenin complex. In summary, MPEG-b-PLLA copolymer surfaces improved initial cell adhesion by stimulation of adhesion molecule gene expression.

scholarly journals Functionalized Poly(ethylene glycol)-Based Bioassay Surface Chemistry That Facilitates Bio-Immobilization and Inhibits Nonspecific Protein, Bacterial, and Mammalian Cell Adhesion

2007 ◽  
Vol 19 (18) ◽  
pp. 4405-4414 ◽  
Author(s):  
Gregory M. Harbers ◽  
Kazunori Emoto ◽  
Charles Greef ◽  
Steven W. Metzger ◽  
Heather N. Woodward ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Ethylene Glycol ◽  
Surface Chemistry ◽  
Mammalian Cell ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Surface modification by poly(ethylene glycol) with different end-grafted groups: Experimental and theoretical study

2021 ◽  
Vol 16 (2) ◽  
pp. 021002
Author(s):  
Xia Han ◽  
Zhaobin Yuan ◽  
Yapeng Niu ◽  
Xueqian Chen ◽  
Honglai Liu
Keyword(s):  
Surface Modification ◽  
Ethylene Glycol ◽  
Theoretical Study ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Surface modification of PDMS microchips with poly(ethylene glycol) derivatives for μTAS applications

2014 ◽  
Vol 35 (16) ◽  
pp. 2346-2352 ◽  
Author(s):  
Richard Piffer Soares de Campos ◽  
Inez Valeria Pagotto Yoshida ◽  
José Alberto Fracassi da Silva
Keyword(s):  
Surface Modification ◽  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Ethylene Glycol Derivatives
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