Stem-Cell-Membrane Camouflaging on Near-Infrared Photoactivated Upconversion Nanoarchitectures for in Vivo Remote-Controlled Photodynamic Therapy

2016 ◽  
Vol 8 (50) ◽  
pp. 34252-34260 ◽  
Author(s):  
Changyong Gao ◽  
Zhihua Lin ◽  
Zhiguang Wu ◽  
Xiankun Lin ◽  
Qiang He
Keyword(s):  
Stem Cell ◽  
Photodynamic Therapy ◽  
Cell Membrane ◽  
Near Infrared

Folic Acid Functionalized Chlorin e6-Superparamagnetic Iron Oxide Nanocarriers as a Theranostic Agent for MRI-Guided Photodynamic Therapy

2021 ◽  
Vol 17 (2) ◽  
pp. 205-215
Author(s):  
Zhenbo Sun ◽  
Mingfang Luo ◽  
Jia Li ◽  
Ailing Wang ◽  
Xucheng Sun ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Folic Acid ◽  
Iron Oxide ◽  
Near Infrared ◽  
Biological Fluids ◽  
Superparamagnetic Iron Oxide ◽  
Chlorin E6 ◽  
Theranostic Agent

Imaging-guided cancer theranostic is a promising strategy for cancer diagnostic and therapeutic. Photodynamic therapy (PDT), as an approved treatment modality, is limited by the poor solubility and dispersion of photosensitizers (PS) in biological fluids. Herein, it is demonstrated that superparamagnetic iron oxide (SPIO)-based nanoparticles (SCFs), prepared by conjugated with Chlorin e6 (Ce6) and modified with folic acid (FA) on the surface, can be used as versatile drug delivery vehicles for effective PDT. The nanoparticles are great carriers for photosensitizer Ce6 with an extremely high loading efficiency. In vitro fluorescence imaging and in vivo magnetic resonance imaging (MRI) results indicated that SCFs selectively accumulated in tumor cells. Under near-infrared laser irradiation, SCFs were confirmed to be capable of inducing low cell viability of RM-1 cells In vitro and displaying efficient tumor ablation with negligible side effects in tumor-bearing mice models.

scholarly journals A self-assembled Ru–Pt metallacage as a lysosome-targeting photosensitizer for 2-photon photodynamic therapy

2019 ◽  
Vol 116 (41) ◽  
pp. 20296-20302 ◽  
Author(s):  
Zhixuan Zhou ◽  
Jiangping Liu ◽  
Juanjuan Huang ◽  
Thomas W. Rees ◽  
Yiliang Wang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Near Infrared ◽  
Building Blocks ◽  
Cell Uptake ◽  
Photon Absorption ◽  
In Vivo Studies ◽  
Infrared Light ◽  
Ros Generation ◽  
Multicellular Spheroids

Photodynamic therapy (PDT) is a treatment procedure that relies on cytotoxic reactive oxygen species (ROS) generated by the light activation of a photosensitizer. The photophysical and biological properties of photosensitizers are vital for the therapeutic outcome of PDT. In this work a 2D rhomboidal metallacycle and a 3D octahedral metallacage were designed and synthesized via the coordination-driven self-assembly of a Ru(II)-based photosensitizer and complementary Pt(II)-based building blocks. The metallacage showed deep-red luminescence, a large 2-photon absorption cross-section, and highly efficient ROS generation. The metallacage was encapsulated into an amphiphilic block copolymer to form nanoparticles to encourage cell uptake and localization. Upon internalization into cells, the nanoparticles selectively accumulate in the lysosomes, a favorable location for PDT. The nanoparticles are almost nontoxic in the dark, and can efficiently destroy tumor cells via the generation of ROS in the lysosomes under 2-photon near-infrared light irradiation. The superb PDT efficacy of the metallacage-containing nanoparticles was further validated by studies on 3D multicellular spheroids (MCS) and in vivo studies on A549 tumor-bearing mice.

Fabrication of red blood cell membrane-camouflaged Cu2−xSe nanoparticles for phototherapy in the second near-infrared window

2019 ◽  
Vol 55 (46) ◽  
pp. 6523-6526 ◽  
Author(s):  
Zhou Liu ◽  
Jinquan Wang ◽  
Kangqiang Qiu ◽  
Xinxing Liao ◽  
Thomas W. Rees ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cell Membrane ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Near Infrared ◽  
Red Blood Cell Membrane ◽  
Photodynamic Therapy Of Cancer ◽  
Se Nanoparticles ◽  
Infrared Window

Cu2−xSe nanoparticles (Cu2−xSeNPs) were camouflaged with a red blood cell membrane (RBC) for synergistic photothermal and photodynamic therapy of cancer in the second near-infrared (NIR II) window.

Discovery of a Monoiodo Aza-BODIPY Near-Infrared Photosensitizer: in vitro and in vivo Evaluation for Photodynamic Therapy

2020 ◽  
Vol 63 (17) ◽  
pp. 9950-9964 ◽  
Author(s):  
Zhiliang Yu ◽  
Junliang Zhou ◽  
Xin Ji ◽  
Guangyu Lin ◽  
Shuang Xu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Near Infrared ◽  
In Vivo Evaluation

Photostable Iridium(III)–Cyanine Complex Nanoparticles for Photoacoustic Imaging Guided Near-Infrared Photodynamic Therapy in Vivo

2019 ◽  
Vol 11 (17) ◽  
pp. 15417-15425 ◽  
Author(s):  
Qi Yang ◽  
Hongyu Jin ◽  
Yucong Gao ◽  
Jiaomin Lin ◽  
Hong Yang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Near Infrared ◽  
Photoacoustic Imaging

Stem Cell Membrane-Coated Nanogels for Highly Efficient In Vivo Tumor Targeted Drug Delivery

Small ◽  
2016 ◽  
Vol 12 (30) ◽  
pp. 4056-4062 ◽  
Author(s):  
Changyong Gao ◽  
Zhihua Lin ◽  
Beatriz Jurado-Sánchez ◽  
Xiankun Lin ◽  
Zhiguang Wu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Stem Cell ◽  
Cell Membrane ◽  
Targeted Drug Delivery ◽  
Highly Efficient ◽  
Targeted Drug
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