A54 Peptide Modified and Redox-Responsive Glucolipid Conjugate Micelles for Intracellular Delivery of Doxorubicin in Hepatocarcinoma Therapy

2016 ◽  
Vol 8 (48) ◽  
pp. 33148-33156 ◽  
Author(s):  
Na Liu ◽  
Yanan Tan ◽  
Yingwen Hu ◽  
Tingting Meng ◽  
Lijuan Wen ◽  
...  
Keyword(s):  
Intracellular Delivery ◽  
Redox Responsive

Folate-decorated polymeric Pt(ii) prodrug micelles for targeted intracellular delivery and cytosolic glutathione-triggered release of platinum anticancer drugs

2015 ◽  
Vol 6 (15) ◽  
pp. 2844-2853 ◽  
Author(s):  
Seyed Jamal Tabatabaei Rezaei ◽  
Vahid Amani ◽  
Mohammad Reza Nabid ◽  
Nasser Safari ◽  
Hassan Niknejad
Keyword(s):  
Anticancer Drugs ◽  
Intracellular Delivery ◽  
Specific Drug ◽  
Triggered Release ◽  
Site Specific ◽  
Platinum Anticancer Drugs ◽  
Redox Responsive ◽  
Cytosolic Glutathione

Bioreducible FA-PEG-b-P(α-Pt(ii)-SS-CL/CL) conjugates have been successfully developed in order to build redox-responsive micelles with targeting and site-specific drug releasing abilities.

Reversible Stabilization of Vesicles: Redox-Responsive Polymer Nanocontainers for Intracellular Delivery

2017 ◽  
Vol 56 (32) ◽  
pp. 9603-9607 ◽  
Author(s):  
Wilke C. de Vries ◽  
David Grill ◽  
Matthias Tesch ◽  
Andrea Ricker ◽  
Harald Nüsse ◽  
...  
Keyword(s):  
Intracellular Delivery ◽  
Redox Responsive ◽  
Responsive Polymer

Inside Back Cover: Reversible Stabilization of Vesicles: Redox-Responsive Polymer Nanocontainers for Intracellular Delivery (Angew. Chem. Int. Ed. 32/2017)

2017 ◽  
Vol 56 (32) ◽  
pp. 9625-9625 ◽  
Author(s):  
Wilke C. de Vries ◽  
David Grill ◽  
Matthias Tesch ◽  
Andrea Ricker ◽  
Harald Nüsse ◽  
...  
Keyword(s):  
Intracellular Delivery ◽  
Back Cover ◽  
Redox Responsive ◽  
Responsive Polymer

Redox-Responsive Polymeric RNAi Based on Multivalent Conjugation of siRNA for Improved Intracellular Delivery

2019 ◽  
Vol 30 (11) ◽  
pp. 2777-2781 ◽  
Author(s):  
Qiufang Bai ◽  
Jun Liu ◽  
Jianan Tang ◽  
Zhen Li ◽  
Xiujue Zheng ◽  
...  
Keyword(s):  
Intracellular Delivery ◽  
Redox Responsive

Intracellular delivery and antitumor effects of a redox-responsive polymeric paclitaxel conjugate based on hyaluronic acid

2015 ◽  
Vol 26 ◽  
pp. 274-285 ◽  
Author(s):  
Shaoping Yin ◽  
Jue Huai ◽  
Xi Chen ◽  
Yong Yang ◽  
Xinxin Zhang ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Intracellular Delivery ◽  
Antitumor Effects ◽  
Redox Responsive

scholarly journals Dually Cross-Linked Core-Shell Structure Nanohydrogel with Redox–Responsive Degradability for Intracellular Delivery

Pharmaceutics ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 2048
Author(s):  
Siyuan Deng ◽  
Maria Rosa Gigliobianco ◽  
Yimin Mijiti ◽  
Marco Minicucci ◽  
Manuela Cortese ◽  
...  
Keyword(s):  
Particle Size ◽  
Hyaluronic Acid ◽  
Cytochrome C ◽  
Horseradish Peroxidase ◽  
Shell Structure ◽  
Intracellular Delivery ◽  
Core Shell ◽  
Hydroxypropyl Methacrylamide ◽  
Redox Responsive ◽  
Core Shell Structure

A redox-responsive nanocarrier is a promising strategy for the intracellular drug release because it protects the payload, prevents its undesirable leakage during extracellular transport, and favors site-specific drug delivery. In this study, we developed a novel redox responsive core-shell structure nanohydrogel prepared by a water in oil nanoemulsion method using two biocompatible synthetic polymers: vinyl sulfonated poly(N-(2-hydroxypropyl) methacrylamide mono/dilactate)-polyethylene glycol-poly(N-(2-hydroxypropyl) methacrylamide mono/dilactate) triblock copolymer, and thiolated hyaluronic acid. The influence on the nanohydrogel particle size and distribution of formulation parameters was investigated by a three-level full factorial design to optimize the preparation conditions. The surface and core-shell morphology of the nanohydrogel were observed by scanning electron microscope, transmission electron microscopy, and further confirmed by Fourier transform infrared spectroscopy and Raman spectroscopy from the standpoint of chemical composition. The redox-responsive biodegradability of the nanohydrogel in reducing environments was determined using glutathione as reducing agent. A nanohydrogel with particle size around 250 nm and polydispersity index around 0.1 is characterized by a thermosensitive shell which jellifies at body temperature and crosslinks at the interface of a redox-responsive hyaluronic acid core via the Michael addition reaction. The nanohydrogel showed good encapsulation efficiency for model macromolecules of different molecular weight (93% for cytochrome C, 47% for horseradish peroxidase, and 90% for bovine serum albumin), capacity to retain the peroxidase-like enzymatic activity (around 90%) of cytochrome C and horseradish peroxidase, and specific redox-responsive release behavior. Additionally, the nanohydrogel exhibited excellent cytocompatibility and internalization efficiency into macrophages. Therefore, the developed core-shell structure nanohydrogel can be considered a promising tool for the potential intracellular delivery of different pharmaceutical applications, including for cancer therapy.

Pyridyl disulfide-based thiol–disulfide exchange reaction: shaping the design of redox-responsive polymeric materials

2020 ◽  
Vol 11 (48) ◽  
pp. 7603-7624
Author(s):  
Ismail Altinbasak ◽  
Mehmet Arslan ◽  
Rana Sanyal ◽  
Amitav Sanyal
Keyword(s):  
Exchange Reaction ◽  
Functional Materials ◽  
Polymeric Materials ◽  
Disulfide Exchange ◽  
Redox Responsive ◽  
Synthetic Approaches

This review provides an overview of synthetic approaches utilized to incorporate the thiol-reactive pyridyl-disulfide motif into various polymeric materials, and briefly highlights its utilization to obtain functional materials.

Ubiquinone-BODIPY nanoparticles for tumor redox-responsive fluorescence imaging and photodynamic activity

2021 ◽  
Author(s):  
Byunghee Hwang ◽  
Tae-Il Kim ◽  
Hyunjin Kim ◽  
Sungjin Jeon ◽  
Yongdoo Choi ◽  
...  
Keyword(s):  
Fluorescence Imaging ◽  
Selective Activation ◽  
Turn On ◽  
Intracellular Environment ◽  
Redox Responsive ◽  
Photodynamic Activity

A ubiquinone-BODIPY photosensitizer self-assembles into nanoparticles (PS-Q-NPs) and undergoes selective activation within the highly reductive intracellular environment of tumors, resulting in “turn-on” fluorescence and photosensitizing activities.

Probing Cellular Outcomes Using Heterobivalent Constructs

2019 ◽  
Author(s):  
Rohit Bhadoria ◽  
Kefeng Ping ◽  
Christer Lohk ◽  
Ivar Järving ◽  
Pavel Starkov
Keyword(s):  
Cell Viability ◽  
Small Molecules ◽  
Cellular Uptake ◽  
Kinase Inhibitors ◽  
Rho Kinase ◽  
Intracellular Delivery ◽  
Rho Kinase Inhibitors

<div> <div> <div> <p>Conjugation techniques are central to improving intracellular delivery of bioactive small molecules. However, tracking and assessing the overall biological outcome of these constructs remains poorly understood. We addressed this issue by having developed a focused library of heterobivalent constructs based on Rho kinase inhibitors to probe various scenarios. By comparing induction of a phenotype of interest vs. cell viability vs. cellular uptake, we demonstrate that such conjugates indeed lead to divergent cellular outcomes. </p> </div> </div> </div>

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