Self-Healing Conductive Injectable Hydrogels with Antibacterial Activity as Cell Delivery Carrier for Cardiac Cell Therapy

2016 ◽  
Vol 8 (27) ◽  
pp. 17138-17150 ◽  
Author(s):  
Ruonan Dong ◽  
Xin Zhao ◽  
Baolin Guo ◽  
Peter X. Ma
Keyword(s):  
Antibacterial Activity ◽  
Cell Therapy ◽  
Cell Delivery ◽  
Self Healing ◽  
Cardiac Cell ◽  
Injectable Hydrogels ◽  
Cardiac Cell Therapy

Cardiac cell therapy: pre-conditioning effects in cell-delivery strategies

Cytotherapy ◽  
2012 ◽  
Vol 14 (3) ◽  
pp. 260-266 ◽  
Author(s):  
Kai Hong Wu ◽  
Xu Ming Mo ◽  
Zhong Chao Han ◽  
Bin Zhou
Keyword(s):  
Cell Therapy ◽  
Cell Delivery ◽  
Cardiac Cell ◽  
Cardiac Cell Therapy ◽  
Delivery Strategies

scholarly journals Injectable Hydrogels for Improving Cardiac Cell Therapy—In Vivo Evidence and Translational Challenges

Gels ◽  
2021 ◽  
Vol 7 (1) ◽  
pp. 7
Author(s):  
Cecilie Hoeeg ◽  
Alireza Dolatshahi-Pirouz ◽  
Bjarke Follin
Keyword(s):  
Cell Therapy ◽  
Cardiac Tissue ◽  
Controlled Trial ◽  
Cell Types ◽  
Cardiac Cell ◽  
Injectable Hydrogels ◽  
Novel Approach ◽  
Cardiac Cell Therapy ◽  
Different Cell Types

Cell therapy has the potential to regenerate cardiac tissue and treat a variety of cardiac diseases which are currently without effective treatment. This novel approach to treatment has demonstrated clinical efficiency, despite low retention of the cell products in the heart. It has been shown that improving retention often leads to improved functional outcome. A feasible method of improving cell graft retention is administration of injectable hydrogels. Over the last decade, a variety of injectable hydrogels have been investigated preclinically for their potential to improve the effects of cardiac cell therapy. These hydrogels are created with different polymers, properties, and additional functional motifs and differ in their approaches for encapsulating different cell types. Only one combinational therapy has been tested in a clinical randomized controlled trial. In this review, the latest research on the potential of injectable hydrogels for delivery of cell therapy is discussed, together with potential roadblocks for clinical translation and recommendations for future explorations to facilitate future translation.

The impact of age on the outcome of cardiac cell therapy

2010 ◽  
Vol 58 (S 01) ◽  
Author(s):  
B Nasseri ◽  
M Kukucka ◽  
SJ Kim ◽  
YH Choi ◽  
KS Kang ◽  
...  
Keyword(s):  
Cell Therapy ◽  
Cardiac Cell ◽  
Cardiac Cell Therapy ◽  
The Impact

Placenta-derived mesenchymal stem cells for allogenic cardiac cell therapy

2012 ◽  
Vol 60 (S 01) ◽  
Author(s):  
R Roy ◽  
M Kukucka ◽  
D Messroghli ◽  
A Brodarac ◽  
M Becher ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Cell Therapy ◽  
Cardiac Cell ◽  
Cardiac Cell Therapy

scholarly journals Cardiac Cell Therapy

2015 ◽  
Vol 116 (8) ◽  
pp. 1291-1292 ◽  
Author(s):  
Birgit Assmus ◽  
Stefanie Dimmeler ◽  
Andreas M. Zeiher
Keyword(s):  
Cell Therapy ◽  
Cardiac Cell ◽  
Cardiac Cell Therapy

scholarly journals Myocardial Restoration: Is It the Cell or the Architecture or Both?

2012 ◽  
Vol 2012 ◽  
pp. 1-11 ◽  
Author(s):  
Duc Thang Vu ◽  
Theo Kofidis
Keyword(s):  
Myocardial Infarction ◽  
Tissue Engineering ◽  
Clinical Trials ◽  
Cell Therapy ◽  
Cardiac Regeneration ◽  
Developed Countries ◽  
Cardiac Cell ◽  
Cardiac Cell Therapy ◽  
Promising Solution ◽  
Structural Aspects

Myocardial infarction is the leading cause of death in developed countries. Cardiac cell therapy has been introduced to clinical trials for more than ten years but its results are still controversial. Tissue engineering has addressed some limitations of cell therapy and appears to be a promising solution for cardiac regeneration. In this review, we would like to summarize the current understanding about the therapeutic effect of cell therapy and tissue engineering under purview of functional and structural aspects, highlighting actual roles of each therapy towards clinical application.

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