BMP-2 Derived Peptide and Dexamethasone Incorporated Mesoporous Silica Nanoparticles for Enhanced Osteogenic Differentiation of Bone Mesenchymal Stem Cells

2015 ◽  
Vol 7 (29) ◽  
pp. 15777-15789 ◽  
Author(s):  
Xiaojun Zhou ◽  
Wei Feng ◽  
Kexin Qiu ◽  
Liang Chen ◽  
Weizhong Wang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Mesoporous Silica ◽  
Osteogenic Differentiation ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Bone Mesenchymal Stem Cells

scholarly journals Positive Effect of Cold Atmospheric Nitrogen Plasma on the Behavior of Mesenchymal Stem Cells Cultured on a Bone Scaffold Containing Iron Oxide-Loaded Silica Nanoparticles Catalyst

2020 ◽  
Vol 21 (13) ◽  
pp. 4738
Author(s):  
Agata Przekora ◽  
Maïté Audemar ◽  
Joanna Pawlat ◽  
Cristina Canal ◽  
Jean-Sébastien Thomann ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Stem Cell ◽  
Osteogenic Differentiation ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Healing Process ◽  
Nitrogen Plasma ◽  
The Impact ◽  
Cells Cultured

Low-temperature atmospheric pressure plasma was demonstrated to have an ability to generate different reactive oxygen and nitrogen species (RONS), showing wide biological actions. Within this study, mesoporous silica nanoparticles (NPs) and FexOy/NPs catalysts were produced and embedded in the polysaccharide matrix of chitosan/curdlan/hydroxyapatite biomaterial. Then, basic physicochemical and structural characterization of the NPs and biomaterials was performed. The primary aim of this work was to evaluate the impact of the combined action of cold nitrogen plasma and the materials produced on proliferation and osteogenic differentiation of human adipose tissue-derived mesenchymal stem cells (ADSCs), which were seeded onto the bone scaffolds containing NPs or FexOy/NPs catalysts. Incorporation of catalysts into the structure of the biomaterial was expected to enhance the formation of plasma-induced RONS, thereby improving stem cell behavior. The results obtained clearly demonstrated that short-time (16s) exposure of ADSCs to nitrogen plasma accelerated proliferation of cells grown on the biomaterial containing FexOy/NPs catalysts and increased osteocalcin production by the cells cultured on the scaffold containing pure NPs. Plasma activation of FexOy/NPs-loaded biomaterial resulted in the formation of appropriate amounts of oxygen-based reactive species that had positive impact on stem cell proliferation and at the same time did not negatively affect their osteogenic differentiation. Therefore, plasma-activated FexOy/NPs-loaded biomaterial is characterized by improved biocompatibility and has great clinical potential to be used in regenerative medicine applications to improve bone healing process.

Efficient transfection and long-term stability of rno-miRNA-26a-5p for osteogenic differentiation by large pore sized mesoporous silica nanoparticles

2021 ◽  
Author(s):  
Sepanta Hosseinpour ◽  
Yuxue Cao ◽  
Jingyu Liu ◽  
Chun Xu ◽  
Laurence J. Walsh
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Mesoporous Silica ◽  
Osteogenic Differentiation ◽  
Mesoporous Silica Nanoparticles ◽  
Long Term Stability ◽  
Marrow Mesenchymal Stem Cells ◽  
Rat Bone

Surface functionalized MSNs with large radial pores delivered miRNA-26a-5p into rat bone marrow mesenchymal stem cells and promote their osteogenic differentiation. Lyophilized dry powder formulation remained functional after 6 months of storage.

Decidua-derived mesenchymal stem cells as carriers of mesoporous silica nanoparticles. In vitro and in vivo evaluation on mammary tumors

2016 ◽  
Vol 33 ◽  
pp. 275-282 ◽  
Author(s):  
Juan L. Paris ◽  
Paz de la Torre ◽  
Miguel Manzano ◽  
M. Victoria Cabañas ◽  
Ana I. Flores ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Mammary Tumors ◽  
In Vivo Evaluation

scholarly journals Platelet lysates-based hydrogels incorporating bioactive mesoporous silica nanoparticles for stem cell osteogenic differentiation

2021 ◽  
Vol 9 ◽  
pp. 100096
Author(s):  
M.T. Tavares ◽  
S.C. Santos ◽  
C.A. Custódio ◽  
J.P.S. Farinha ◽  
C. Baleizão ◽  
...  
Keyword(s):  
Stem Cell ◽  
Mesoporous Silica ◽  
Osteogenic Differentiation ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles
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