Applying Thermosettable Zwitterionic Copolymers as General Fouling-Resistant and Thermal-Tolerant Biomaterial Interfaces

2015 ◽  
Vol 7 (19) ◽  
pp. 10096-10107 ◽  
Author(s):  
Ying-Nien Chou ◽  
Yung Chang ◽  
Ten-Chin Wen
Keyword(s):  
Biomaterial Interfaces

scholarly journals High-resolution three-dimensional probes of biomaterials and their interfaces

2012 ◽  
Vol 370 (1963) ◽  
pp. 1337-1351 ◽  
Author(s):  
Kathryn Grandfield ◽  
Anders Palmquist ◽  
Håkan Engqvist
Keyword(s):  
High Resolution ◽  
Electron Tomography ◽  
Three Dimensional ◽  
Controlled Drug Release ◽  
Biological Tissues ◽  
Dimensional Structure ◽  
Bone Interface ◽  
Biomaterial Interfaces ◽  
Titania Coating

Interfacial relationships between biomaterials and tissues strongly influence the success of implant materials and their long-term functionality. Owing to the inhomogeneity of biological tissues at an interface, in particular bone tissue, two-dimensional images often lack detail on the interfacial morphological complexity. Furthermore, the increasing use of nanotechnology in the design and production of biomaterials demands characterization techniques on a similar length scale. Electron tomography (ET) can meet these challenges by enabling high-resolution three-dimensional imaging of biomaterial interfaces. In this article, we review the fundamentals of ET and highlight its recent applications in probing the three-dimensional structure of bioceramics and their interfaces, with particular focus on the hydroxyapatite–bone interface, titanium dioxide–bone interface and a mesoporous titania coating for controlled drug release.

Nanoimprinting of Biomaterial Interfaces

2003 ◽  
Vol 9 (S03) ◽  
pp. 458-459
Author(s):  
Steven Lenhert ◽  
Lifeng Chi ◽  
Hans Peter Wiesmann
Keyword(s):  
Biomaterial Interfaces

Structure and Dynamics of Proteins Adsorbed to Biomaterial Interfaces

2007 ◽  
Author(s):  
Gary P. Drobny ◽  
Joanna R. Long ◽  
Wendy J. Shaw ◽  
Myriam Cotten ◽  
Patrick S. Stayton
Keyword(s):  
Structure And Dynamics ◽  
Biomaterial Interfaces

scholarly journals Proteins, platelets, and blood coagulation at biomaterial interfaces

2014 ◽  
Vol 124 ◽  
pp. 49-68 ◽  
Author(s):  
Li-Chong Xu ◽  
James W. Bauer ◽  
Christopher A. Siedlecki
Keyword(s):  
Blood Coagulation ◽  
Biomaterial Interfaces

scholarly journals Human foetal osteoblastic cell response to polymer-demixed nanotopographic interfaces

2005 ◽  
Vol 2 (2) ◽  
pp. 97-108 ◽  
Author(s):  
Jung Yul Lim ◽  
Joshua C Hansen ◽  
Christopher A Siedlecki ◽  
James Runt ◽  
Henry J Donahue
Keyword(s):  
Cell Response ◽  
Cell Function ◽  
Early Stage ◽  
Control Cell ◽  
Bone Cell ◽  
Cell Phenotype ◽  
Osteoblastic Cell ◽  
Bone Cell Differentiation ◽  
Biomaterial Interfaces ◽  
Cells Cultured

Nanoscale cell–substratum interactions are of significant interest in various biomedical applications. We investigated human foetal osteoblastic cell response to randomly distributed nanoisland topography with varying heights (11, 38 and 85 nm) produced by a polystyrene (PS)/polybromostyrene polymer-demixing technique. Cells displayed island-conforming lamellipodia spreading, and filopodia projections appeared to play a role in sensing the nanotopography. Cells cultured on 11 nm high islands displayed significantly enhanced cell spreading and larger cell dimensions than cells on larger nanoislands or flat PS control, on which cells often displayed a stellate shape. Development of signal transmitting structures such as focal adhesive vinculin protein and cytoskeletal actin stress fibres was more pronounced, as was their colocalization, in cells cultured on smaller nanoisland surfaces. Cell adhesion and proliferation were greater with decreasing island height. Alkaline phosphatase (AP) activity, an early stage marker of bone cell differentiation, also exhibited nanotopography dependence, i.e. higher AP activity on 11 nm islands compared with that on larger islands or flat PS. Therefore, randomly distributed island topography with varying nanoscale heights not only affect adhesion-related cell behaviour but also bone cell phenotype. Our results suggest that modulation of nanoscale topography may be exploited to control cell function at cell–biomaterial interfaces.

Ultrastructural characterization of tooth–biomaterial interfaces prepared with broad and focused ion beams

2009 ◽  
Vol 25 (11) ◽  
pp. 1325-1337 ◽  
Author(s):  
E. Coutinho ◽  
T. Jarmar ◽  
F. Svahn ◽  
A.A. Neves ◽  
B. Verlinden ◽  
...  
Keyword(s):  
Ion Beams ◽  
Focused Ion Beams ◽  
Ultrastructural Characterization ◽  
Biomaterial Interfaces
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