Utilization of Nonradiative Excited-State Dissipation for Promoted Phototheranostics Based on an AIE-Active Type I ROS Generator

2021 ◽  
Author(s):  
Yifei Wang ◽  
Yudong Sun ◽  
Jiabing Ran ◽  
Huiran Yang ◽  
Shuzhang Xiao ◽  
...  
Keyword(s):  
Excited State ◽  
Type I ◽  
Active Type

scholarly journals Electron Transfer Initiated Reactions Photoinduced by Pterins

Pteridines ◽  
2011 ◽  
Vol 22 (1) ◽  
pp. 111-119 ◽  
Author(s):  
Carolina Lorente ◽  
Gabriela Petroselli ◽  
M. Laura Dántola ◽  
Esther Oliveros ◽  
Andrés H. Thomas
Keyword(s):  
Electron Transfer ◽  
Excited State ◽  
Redox Reactions ◽  
Type I ◽  
Biological Processes ◽  
Type Ii ◽  
Triplet Excited State ◽  
Oxygen Production ◽  
Production Type ◽  
Transfer Mechanisms

Abstract Interest in the photochemistry and photophysics of pterins has increased since the participation of this family of compounds in different photobiological processes has been suggested or demonstrated in recent decades. Pterins participate in relevant biological processes, such as metabolic redox reactions, and can photoinduce the oxidation of biomolecules through both electron transfer mechanisms (Type I) and singlet oxygen production (Type II). This article describes recent findings on electron transfer-initiated reactions photoinduced by the triplet excited state of pterins and connects them in the context of photosensitized processes of biological relevance.

1291 ANALYSIS OF CIRCULATING CD4+ AND CD8+ T MEMORY SUBSETS IN ACTIVE TYPE I AUTOIMMUNE HEPATITIS AND DURING ITS BIOCHEMICAL REMISSION

2011 ◽  
Vol 54 ◽  
pp. S509
Author(s):  
N.E. Ferreyra Solari ◽  
D. Levi ◽  
A. Villamil ◽  
P. Baz ◽  
A. Billordo ◽  
...  
Keyword(s):  
Autoimmune Hepatitis ◽  
Type I ◽  
Active Type ◽  
Biochemical Remission

Ground- and excited-state interactions of 2,7,12,17-tetraphenylporphycene with model target biomolecules for type-I photodynamic therapy

2009 ◽  
Vol 13 (01) ◽  
pp. 99-106 ◽  
Author(s):  
Noemí Rubio ◽  
Víctor Martínez-Junza ◽  
Jordi Estruga ◽  
José I. Borrell ◽  
Margarita Mora ◽  
...  
Keyword(s):  
Electron Transfer ◽  
Photodynamic Therapy ◽  
Excited State ◽  
Singlet Oxygen ◽  
Cell Lines ◽  
Mechanism Of Action ◽  
Photophysical Properties ◽  
Type I ◽  
Type Ii ◽  
Hydrophobic Compound

Biosubstrate-sensitizer binding is one of the factors that enhances the type-I mechanism over the type-II in the whole photodynamic process. 2,7,12,17-Tetraphenylporphycene (TPPo), a second-generation photosensitizer, is a hydrophobic compound with good photophysical properties for photodynamic therapy applications that has proved its ability for the photoinactivation of different cell lines. Nevertheless, little is known about its mechanism of action. This paper focuses on the study of the interaction/binding of TPPo with different model biomolecules that may favor the type-I mechanism in the overall photodynamic process, including nucleosides, proteins, and phospholipids. Compared with more hydrophilic photosensitizers, it is concluded that TPPo is more likely to undergo type-II (singlet oxygen) than type-I (electron transfer) photodynamic processes in biological environments.

scholarly journals Ultrafast excited-state charge-transfer dynamics in laccase type I copper site

2015 ◽  
Vol 200-201 ◽  
pp. 41-47 ◽  
Author(s):  
Ines Delfino ◽  
Daniele Viola ◽  
Giulio Cerullo ◽  
Maria Lepore
Keyword(s):  
Excited State ◽  
Charge Transfer ◽  
Type I ◽  
Copper Site ◽  
Charge Transfer Dynamics ◽  
State Charge

scholarly journals Expression, purification and crystallization of a membrane-associated, catalytically active type I signal peptidase fromStaphylococcus aureus

2015 ◽  
Vol 71 (1) ◽  
pp. 61-65 ◽  
Author(s):  
Yi Tian Ting ◽  
Gaëlle Batot ◽  
Edward N. Baker ◽  
Paul G. Young
Keyword(s):  
Serine Proteases ◽  
Protein Modification ◽  
Catalytic Mechanism ◽  
Signal Peptidase ◽  
Monoclinic Space Group ◽  
Type I ◽  
Active Type ◽  
Catalytically Active ◽  
Signal Peptidases ◽  
Bacterial Type

Staphylococcus aureusinfections are becoming increasingly difficult to treat as they rapidly develop resistance to existing antibiotics. Bacterial type I signal peptidases are membrane-associated, cell-surface serine proteases with a unique catalytic mechanism that differs from that of eukaryotic endoplasmic reticulum signal peptidases. They are thus potential antimicrobial targets.S. aureushas a catalytically active type I signal peptidase, SpsB, that is essential for cell viability. To elucidate its structure, thespsBgene fromS. aureusNewman strain was cloned and overexpressed inEscherichia coli. After exploring many different protein-modification constructs, SpsB was expressed as a fusion protein with maltose-binding protein and crystallized by hanging-drop vapour diffusion. The crystals belonged to the monoclinic space groupP21and diffracted to 2.05 Å resolution. The crystal structure of SpsB is anticipated to provide structural insight into Gram-positive signal peptidases and to aid in the development of antibacterial agents that target type I signal peptidases.

Cloning, expression and characterization of the recombinant cold-active type-I pullulanase from Shewanella arctica

2015 ◽  
Vol 116 ◽  
pp. 70-77 ◽  
Author(s):  
Skander Elleuche ◽  
Farah M. Qoura ◽  
Ute Lorenz ◽  
Torben Rehn ◽  
Thomas Brück ◽  
...  
Keyword(s):  
Type I ◽  
Active Type ◽  
Cold Active

Localization of the active type I DNA topoisomerase gene on human chromosome 20q11.2-13.1, and two pseudogenes on chromosomes 1q23-24 and 22q11.2-13.1

1989 ◽  
Vol 84 (1) ◽  
pp. 6-10 ◽  
Author(s):  
N. Kunze ◽  
G.C. Yang ◽  
Z.Y. Jiang ◽  
H. Hameister ◽  
S. Adolph ◽  
...  
Keyword(s):  
Human Chromosome ◽  
Type I ◽  
Dna Topoisomerase ◽  
Active Type
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