Coassembled Chitosan–Hyaluronic Acid Nanoparticles as a Theranostic Agent Targeting Alzheimer’s β-Amyloid

2021 ◽  
Author(s):  
Wenjuan Wang ◽  
Miaomiao Liu ◽  
Weiqun Gao ◽  
Yan Sun ◽  
Xiaoyan Dong
Keyword(s):  
Hyaluronic Acid ◽  
Theranostic Agent ◽  
Β Amyloid

Activatable Hyaluronic Acid Nanoparticle as a Theranostic Agent for Optical/Photoacoustic Image-Guided Photothermal Therapy

ACS Nano ◽  
2014 ◽  
Vol 8 (12) ◽  
pp. 12250-12258 ◽  
Author(s):  
Liwen Zhang ◽  
Shi Gao ◽  
Fan Zhang ◽  
Kai Yang ◽  
Qingjie Ma ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Photothermal Therapy ◽  
Image Guided ◽  
Theranostic Agent

A natural polysaccharide mediated MOF-based Ce6 delivery system with improved biological properties for photodynamic therapy

2020 ◽  
Vol 8 (7) ◽  
pp. 1481-1488 ◽  
Author(s):  
Xinwei Fu ◽  
Zhangyou Yang ◽  
Tao Deng ◽  
Jun Chen ◽  
Yilin Wen ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Hyaluronic Acid ◽  
Delivery System ◽  
Biological Properties ◽  
Chlorin E6 ◽  
Zeolitic Imidazolate Framework ◽  
Theranostic Agent ◽  
Natural Polysaccharide

The hyaluronic acid mediated zeolitic imidazolate framework-8-based Chlorin e6 theranostic agent used for tumor photodynamic therapy.

A theranostic agent for in vivo near-infrared imaging of β-amyloid species and inhibition of β-amyloid aggregation

Biomaterials ◽  
2016 ◽  
Vol 94 ◽  
pp. 84-92 ◽  
Author(s):  
Yinhui Li ◽  
Di Xu ◽  
See-Lok Ho ◽  
Hung-Wing Li ◽  
Ronghua Yang ◽  
...  
Keyword(s):  
Near Infrared ◽  
Infrared Imaging ◽  
Amyloid Aggregation ◽  
Near Infrared Imaging ◽  
Theranostic Agent ◽  
Β Amyloid

Healing of Circular Defects in the Rabbit Medial Meniscus Can Occur Spontaneously and Is not Improved by Intra-Articular Hyaluronic Acid

1996 ◽  
Vol 09 (02) ◽  
pp. 60-5 ◽  
Author(s):  
N. Hope ◽  
P. Ghosh ◽  
S. Collier
Keyword(s):  
Hyaluronic Acid ◽  
Medial Meniscus ◽  
Chondroitin Sulphate ◽  
Rabbit Model ◽  
Type Ii Collagen ◽  
Type Ii ◽  
Keratan Sulphate ◽  
Meniscal Healing ◽  
Meniscus Healing ◽  
Made In

SummaryThe aim of this study was to determine the effects of intra-articular hyaluronic acid on meniscal healing. Circular defects, 1.0 mm in diameter, were made in the anterior third of the medial meniscus in rabbits. In one joint, 0.4 ml hyaluronic acid (Healon®) was instilled, and in the contralateral (control) joint, 0.4 ml Ringer’s saline. Four rabbits were killed after four, eight and 12 weeks and the menisci examined histologically. By eight weeks most of the lesions had healed by filling with hyaline-like cartilage. Healing was not improved by hyaluronic acid treatment. The repair tissue stained strongly with alcian blue, and the presence of type II collagen, keratan sulphate, and chondroitin sulphate was demonstrated by immunohistochemical localisation. In contrast to the circular defects, longitudinal incisions made in the medial menisci of a further six rabbits did not show any healing after 12 weeks, indicating that the shape of the lesion largely determined the potential for healing.The effect of hyaluronic acid on meniscal healing was tested in a rabbit model. With one millimeter circular lesions in the medial meniscus, healing by filling with hyalinelike cartilage was not significantly affected by the application of hyaluronic acid intra-articularly at the time of surgery, compared to saline controls, as assessed histologically four, eight and 12 weeks after the operation.

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