Ultrashort Peptides and Hyaluronic Acid-Based Injectable Composite Hydrogels for Sustained Drug Release and Chronic Diabetic Wound Healing

2021 ◽  
Author(s):  
Ling Wang ◽  
Jing Li ◽  
Yue Xiong ◽  
Yihang Wu ◽  
Fen Yang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Hyaluronic Acid ◽  
Drug Release ◽  
Diabetic Wound ◽  
Sustained Drug Release ◽  
Composite Hydrogels ◽  
Diabetic Wound Healing

Polyvinyl Alcohol/Chitosan Composite Hydrogels with Sustained Release of Traditional Tibetan Medicine for Promoting Chronic Diabetic Wound Healing

2021 ◽  
Author(s):  
Xingyu Chen ◽  
Zuxin Wang ◽  
Shan Gao ◽  
Wanlin Zhang ◽  
Hanwen Gong ◽  
...  
Keyword(s):  
Wound Healing ◽  
Polyvinyl Alcohol ◽  
Sustained Release ◽  
Skin Diseases ◽  
Tibetan Medicine ◽  
Diabetic Wound ◽  
Composite Hydrogels ◽  
Diabetic Wound Healing ◽  
Traditional Tibetan Medicine ◽  
Chitosan Composite

The Tibetan eighteen flavor dangshen pills (TEP) are composed of 18 traditional Tibetan medicines, which are commonly used in the treatment of skin diseases in the Tibetan medicine system. They...

scholarly journals Stem Cell-Containing Hyaluronic Acid-Based Spongy Hydrogels for Integrated Diabetic Wound Healing

2017 ◽  
Vol 137 (7) ◽  
pp. 1541-1551 ◽  
Author(s):  
Lucília Pereira da Silva ◽  
Tírcia Carlos Santos ◽  
Daniel Barreira Rodrigues ◽  
Rogério Pedro Pirraco ◽  
Mariana Teixeira Cerqueira ◽  
...  
Keyword(s):  
Wound Healing ◽  
Stem Cell ◽  
Hyaluronic Acid ◽  
Diabetic Wound ◽  
Diabetic Wound Healing

scholarly journals An intrinsically bioactive hydrogel with on-demand drug release behaviors for diabetic wound healing

2021 ◽  
Vol 6 (12) ◽  
pp. 4592-4606
Author(s):  
Bin Hu ◽  
Mingzhu Gao ◽  
Kofi Oti Boakye-Yiadom ◽  
William Ho ◽  
Wei Yu ◽  
...  
Keyword(s):  
Wound Healing ◽  
Drug Release ◽  
Diabetic Wound ◽  
On Demand ◽  
Diabetic Wound Healing

scholarly journals FORMULATION AND EVALUATION OF SIMVASTATIN LOADED MICROEMULSION BASED GEL: IN VITRO CHARACTERIZATION

2021 ◽  
Vol 12 (7) ◽  
pp. 1-7
Author(s):  
Maria Saifee ◽  
Pragati Bhaske ◽  
Reshma Toshniwal
Keyword(s):  
Wound Healing ◽  
Drug Release ◽  
Gelling Agent ◽  
Diabetic Wound ◽  
In Vitro Drug Release ◽  
Globule Size ◽  
Microemulsion Based Gel ◽  
Diabetic Wound Healing ◽  
Microemulsion Gel

The Simvastatin loaded microemulsion based gel was formulated and in-vitro evaluation was done for the treatment of diabetic wound healing. Simvastatin is BCS class II drug which promotes wound healing by increasing the production of vascular endothelial growth factor (VEGF). Microemulsions (MEs) are oil and water colloidal system stabilized by the mixture of surfactant and co-surfactant offering enhance skin permeability for both hydrophobic and hydrophilic drugs. At first, microemulsion (ME) was prepared by water titration method and the existence of ME region was determined using pseudo-ternary phase diagram. Formulations were prepared using oil (oleic acid), Tween 80 and PEG 400 as surfactant and co-surfactant. Optimization of formulation was done using 32 factorial designs. Carbopol 940 was used as gelling agent for preparing microemulsion gel. The formulations were evaluated for physical appearance globule size, polydispersity index, zeta potential, percent transmittance, thermodynamic stability, dilution test, drug content, and in vitro drug release. The optimized formulation of ME showed average globule size of 151 nm and the optimized ME gel had a homogeneous texture, showed good spreadability and in vitro drug release. The present study indicates the simvastatin loaded microemulsion gel could act as promising vehicle for topical drug delivery of drug for diabetic wound healing.

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