scholarly journals HAP-Multitag, a PET and Positive MRI Contrast Nanotracer for the Longitudinal Characterization of Vascular Calcifications in Atherosclerosis

2021 ◽  
Vol 13 (38) ◽  
pp. 45279-45290
Author(s):  
Juan Pellico ◽  
Irene Fernández-Barahona ◽  
Jesús Ruiz-Cabello ◽  
Lucía Gutiérrez ◽  
María Muñoz-Hernando ◽  
...  
Keyword(s):  
Vascular Calcifications ◽  
Mri Contrast

scholarly journals HAP-multitag, a PET and positive MRI contrast nanotracer for the longitudinal characterization of vascular calcifications in atherosclerosis

2020 ◽  
Author(s):  
Juan Pellico ◽  
Irene Fernández-Barahona ◽  
Jesús Ruiz-Cabello ◽  
Lucía Gutiérrez ◽  
María J. Sánchez-Guisado ◽  
...  
Keyword(s):  
Magnetic Nanoparticle ◽  
Atherosclerotic Lesion ◽  
Positive Contrast ◽  
Vascular Calcifications ◽  
Mri Contrast ◽  
Plaque Instability ◽  
Imaging Probes

ABSTRACTVascular microcalcifications are associated with atherosclerosis plaque instability and, therefore, to increased mortality. Because of this key role, several imaging probes have been developed for their in vivo identification. Among them [18F]FNa is the gold standard, showing a large uptake in the whole skeleton. Here, we push the field towards the combined anatomical and functional early characterization of atherosclerosis. For that, we have developed HAP-multitag, a bisphosphonate-functionalized 68Ga magnetic nanoparticle showing high affinity towards most common calcium salts present in microcalcifications, particularly hydroxyapatite. We characterized this interaction in vitro and in vivo, showing a massive uptake in the atherosclerotic lesion identified by PET and positive contrast MRI. In addition, this accumulation was found to be dependent on the calcification progression, with a maximum uptake in the microcalcification stage. These results confirmed the ability of HAP-multitag to identify vascular calcifications by PET/(T1)MRI during the vulnerable stages of the plaque progression.

scholarly journals The Use of Imaging Techniques in Chronic Kidney Disease-Mineral and Bone Disorders (CKD-MBD)—A Systematic Review

Diagnostics ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 772
Author(s):  
Ana Pimentel ◽  
Jordi Bover ◽  
Grahame Elder ◽  
Martine Cohen-Solal ◽  
Pablo Antonio Ureña-Torres
Keyword(s):  
Computed Tomography ◽  
Chronic Kidney Disease ◽  
Magnetic Resonance ◽  
Kidney Disease ◽  
Imaging Techniques ◽  
Quantitative Computed Tomography ◽  
Vertebral Fracture Assessment ◽  
Vascular Calcifications ◽  
Ckd Stage

Although frequently silent, mineral and bone disease (MBD) is one of the most precocious complication of chronic kidney disease (CKD) and is omnipresent in patients with CKD stage 5. Its pathophysiology is complex, but basically, disturbances in vitamin D, phosphate, and calcium metabolism lead to a diverse range of clinical manifestations with secondary hyperparathyroidism usually being the most frequent. With the decline in renal function, CKD-MBD may induce microstructural changes in bone, vascular system and soft tissues, which results in macrostructural lesions, such as low bone mineral density (BMD) resulting in skeletal fractures, vascular and soft tissue calcifications. Moreover, low BMD, fractures, and vascular calcifications are linked with increased risk of cardiovascular mortality and all-cause mortality. Therefore, a better characterization of CKD-MBD patterns, beyond biochemical markers, is helpful to adapt therapies and monitor strategies as used in the general population. An in-depth characterization of bone health is required, which includes an evaluation of cortical and trabecular bone structure and density and the degree of bone remodeling through bone biomarkers. Standard radiological imaging is generally used for the diagnosis of fracture or pseudo-fractures, vascular calcifications and other features of CKD-MBD. However, bone fractures can also be diagnosed using computed tomography (CT) scan, magnetic resonance (MR) imaging and vertebral fracture assessment (VFA). Fracture risk can be predicted by bone densitometry using dual-energy X-ray absorptiometry (DXA), quantitative computed tomography (QTC) and peripheral quantitative computed tomography (pQTC), quantitative ultrasound (QUS) and most recently magnetic resonance micro-imaging. Quantitative methods to assess bone consistency and strength complete the study and adjust the clinical management when integrated with clinical factors. The aim of this review is to provide a brief and comprehensive update of imaging techniques available for the diagnosis, prevention, treatment and monitoring of CKD-MBD.

Synthesis and characterization of a new water-soluble endohedral metallofullerene for MRI contrast agents

Carbon ◽  
2006 ◽  
Vol 44 (3) ◽  
pp. 496-500 ◽  
Author(s):  
Chun-Ying Shu ◽  
Li-Hua Gan ◽  
Chun-Ru Wang ◽  
Xin-long Pei ◽  
Hong-bin Han
Keyword(s):  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Water Soluble ◽  
Synthesis And Characterization ◽  
Mri Contrast ◽  
Endohedral Metallofullerene

scholarly journals Characterization of a Manganese-Containing Nanoparticle as an MRI Contrast Agent

2019 ◽  
Vol 2019 (13) ◽  
pp. 1759-1766
Author(s):  
Eliana Gianolio ◽  
Sania Bäckström ◽  
Rodrigo M. Petoral ◽  
Anders Olsson ◽  
Silvio Aime ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Mri Contrast Agent ◽  
Mri Contrast

Synthesis and characterization of pH-sensitive, biotinylated MRI contrast agents and their conjugates with avidin

2013 ◽  
Vol 11 (8) ◽  
pp. 1294-1305 ◽  
Author(s):  
Sandip M. Vibhute ◽  
Jörn Engelmann ◽  
Tatjana Verbić ◽  
Martin E. Maier ◽  
Nikos K. Logothetis ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Ph Sensitive ◽  
Synthesis And Characterization ◽  
Mri Contrast

scholarly journals Characterization of Cysteine Coated Magnetite Nanoparticles as MRI Contrast Agent

2012 ◽  
Vol 4 (3) ◽  
pp. 180-183 ◽  
Author(s):  
Reza Ahmadi ◽  
Ning Gu ◽  
Hamid Reza Madaah Hosseini
Keyword(s):  
Contrast Agent ◽  
Magnetite Nanoparticles ◽  
Mri Contrast Agent ◽  
Mri Contrast
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