Chimeric Peptides Quickly Modify the Surface of Personalized 3D Printing Titanium Implants to Promote Osseointegration

2021 ◽  
Author(s):  
Zhezhe Zhao ◽  
Shiqing Ma ◽  
Chenxuan Wu ◽  
Xuewen Li ◽  
Xinying Ma ◽  
...  
Keyword(s):  
3D Printing ◽  
Titanium Implants ◽  
Chimeric Peptides

scholarly journals Improvement of osseointegration by recruiting stem cells to titanium implants fabricated with 3D printing

2019 ◽  
Vol 1463 (1) ◽  
pp. 37-44 ◽  
Author(s):  
Mary Bollman ◽  
Raphael Malbrue ◽  
Chunhong Li ◽  
Hong Yao ◽  
Shengmin Guo ◽  
...  
Keyword(s):  
Stem Cells ◽  
3D Printing ◽  
Titanium Implants

scholarly journals Benefits and Biosafety of Use of 3D-Printing Technology for Titanium Biomedical Implants: A Pilot Study in the Rabbit Model

2021 ◽  
Vol 22 (16) ◽  
pp. 8480
Author(s):  
Sabrina Livia Ng ◽  
Subhabrata Das ◽  
Yen-Peng Ting ◽  
Raymond Chung Wen Wong ◽  
Nattharee Chanchareonsook
Keyword(s):  
Pilot Study ◽  
3D Printing ◽  
Gold Standard ◽  
Rabbit Model ◽  
Titanium Implants ◽  
Control Group ◽  
Organ Systems ◽  
Osteosynthesis Plate ◽  
Significant Difference ◽  
3D Printed

Background: Titanium has been used in osteosynthesis for decades and its compatibility and safety is unquestioned. Studies have shown that there is release and collection of titanium in the organ systems with little note of toxicity. The gold standard is considered to be titanium osteosynthesis plate produced by milling methods. The use of customized titanium plates produced with 3D printing, specifically direct metal laser sintering, have found increasing use in recent years. It is unknown how much titanium is released in these printed titanium implants, which is known to be potentially porous, depending on the heat settings of the printer. We hypothesize that the amount of titanium released in printed titanium implants may be potentially more or equal compared to the gold standard, which is the implant produced by milling. Methods: We studied the biosafety of this technology and its products by measuring serum and organ titanium levels after implantation of 3D-printed versus traditionally fabrication titanium plates and screws in a pilot study using the rabbit model. A total of nine rabbits were used, with three each in the control, milled and printed titanium group. The animals were euthanized after six months. Serum and organs of the reticuloendothelial system were harvested, digested and assayed for titanium levels. Results: Organ and serum titanium levels were significantly higher in rabbit subjects implanted with titanium implants (milled and printed) compared to the control group. However, there was no significant difference in organ and serum titanium levels of subjects implanted with milled and traditionally fabricated titanium implants. Conclusions: The biosafety of use of 3D-printed titanium implants and traditionally fabricated titanium implants are comparable. With this in mind, 3D-printed custom implants can not only replace, but will very possibly surpass traditionally fabricated titanium implants in the mode and extent of use.

Micro- and nano-structured 3D printed titanium implants with a hydroxyapatite coating for improved osseointegration

2018 ◽  
Vol 6 (19) ◽  
pp. 3136-3144 ◽  
Author(s):  
Jie Qin ◽  
Dongqing Yang ◽  
Shaheer Maher ◽  
Luis Lima-Marques ◽  
Yanmin Zhou ◽  
...  
Keyword(s):  
3D Printing ◽  
Titanium Implants ◽  
Hydroxyapatite Coating ◽  
Printing Technology ◽  
3D Printing Technology ◽  
3D Printed

3D printing technology combined with electrochemical nano-structuring and HA modification is a promising approach for the fabrication of Ti implants with improved osseointegration.

scholarly journals Effect of Shot Peening on the Mechanical Properties and Cytotoxicity Behaviour of Titanium Implants Produced by 3D Printing Technology

2019 ◽  
Vol 2019 ◽  
pp. 1-11 ◽  
Author(s):  
Remigiusz Żebrowski ◽  
Mariusz Walczak ◽  
Agnieszka Korga ◽  
Magdalena Iwan ◽  
Mirosław Szala
Keyword(s):  
Surface Layer ◽  
3D Printing ◽  
Shot Peening ◽  
Surface Defects ◽  
Biological Properties ◽  
Titanium Implants ◽  
Metal Powders ◽  
Printing Technology ◽  
3D Printing Technology ◽  
Steel Shot

Structural discontinuities characterize the implants produced directly from metal powders in 3D printing technology. Mainly, the surface defects should be subjected to procedures associated with surface layer modification (likewise shot peening) resulting in the increase of the implant service life maintaining optimal biocompatibility. Therefore, the purpose of the present study was to investigate the effect of type of shot used for the peening process on the Ti-6Al-4V implants functional properties as well as the biological properties. The components were produced by DMLS (direct metal laser sintering) additive technology. The surfaces of titanium specimens have been subjected to the shot peening process by means of three different shots, i.e., CrNi steel shot, crushed nut shells, and ceramic balls shot. Then, the specimens have been subjected to profilometric analysis, microhardness tests, and static strength testing as well as to the assessment of biocompatibility in respect of cytotoxicity using human BJ fibroblasts. The shot peening process causes the strengthening of surface layer and the increase of strength parameters. Furthermore, the test results indicate good biocompatibility of surfaces being tested, and the effect of shot peening process on the titanium alloy cytotoxicity is acceptable. At the same time, most favourable behaviour in respect of cytotoxicity has been found in the case of surfaces modified by means of ceramic balls > nut shells > CrNi steel shot correspondingly.

Osseointegration interface of calcified bone and endosseous implants

1992 ◽  
Vol 50 (2) ◽  
pp. 1096-1097
Author(s):  
K.E. Krizan ◽  
J.E. Laffoon ◽  
M.J. Buckley
Keyword(s):  
Structure And Function ◽  
Titanium Implants ◽  
En Bloc ◽  
Endosseous Implants ◽  
Ultrastructural Studies ◽  
The Past ◽  
Cacodylate Buffer ◽  
One Year ◽  
And Function

With increase use of tissue-integrated prostheses in recent years it is a goal to understand what is happening at the interface between haversion bone and bulk metal. This study uses electron microscopy (EM) techniques to establish parameters for osseointegration (structure and function between bone and nonload-carrying implants) in an animal model. In the past the interface has been evaluated extensively with light microscopy methods. Today researchers are using the EM for ultrastructural studies of the bone tissue and implant responses to an in vivo environment. Under general anesthesia nine adult mongrel dogs received three Brånemark (Nobelpharma) 3.75 × 7 mm titanium implants surgical placed in their left zygomatic arch. After a one year healing period the animals were injected with a routine bone marker (oxytetracycline), euthanized and perfused via aortic cannulation with 3% glutaraldehyde in 0.1M cacodylate buffer pH 7.2. Implants were retrieved en bloc, harvest radiographs made (Fig. 1), and routinely embedded in plastic. Tissue and implants were cut into 300 micron thick wafers, longitudinally to the implant with an Isomet saw and diamond wafering blade [Beuhler] until the center of the implant was reached.

Michael Pawlyn: Push the limits of 3D printing

Nature ◽  
2013 ◽  
Vol 494 (7436) ◽  
pp. 174-174 ◽  
Author(s):  
Michael Pawlyn
Keyword(s):  
3D Printing

High-resolution 3D printing in seconds

Nature ◽  
2020 ◽  
Vol 588 (7839) ◽  
pp. 594-595
Author(s):  
Cameron Darkes-Burkey ◽  
Robert F. Shepherd
Keyword(s):  
High Resolution ◽  
3D Printing
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