pH-Responsive Hybrid Nanoparticles for Imaging Spatiotemporal pH Changes in Biofilm-Dentin Microenvironments

2021 ◽  
Author(s):  
Guang-Rong Tan ◽  
Chin-Ying Stephen Hsu ◽  
Yong Zhang
Keyword(s):  
Hybrid Nanoparticles ◽  
Ph Responsive ◽  
Ph Changes

scholarly journals Engineering pH-responsive switching of donor–π–acceptor chromophore alignments along a peptide nanotube scaffold

RSC Advances ◽  
2020 ◽  
Vol 10 (6) ◽  
pp. 3588-3592 ◽  
Author(s):  
Yuki Tabata ◽  
Yusuke Kamano ◽  
Shunsaku Kimura ◽  
Hirotaka Uji
Keyword(s):  
Cyclic Peptides ◽  
Ph Responsive ◽  
Ph Changes ◽  
Left Handed ◽  
Peptide Nanotube

pH-Responsive switching between a left-handed chiral and random alignments of D–π–A naphthalimides along a peptide nanotube (PNT) composed of tri-β-cyclic peptides was attained in response to repeated pH changes.

Synthesis of core-shell hybrid nanoparticles with pH responsive core and silica shell and their surface characterization

2020 ◽  
Vol 280 ◽  
pp. 128550
Author(s):  
L. García-Uriostegui ◽  
Ezequiel Delgado ◽  
H.I. Melendez-Ortiz ◽  
Guillermo Toriz
Keyword(s):  
Surface Characterization ◽  
Silica Shell ◽  
Hybrid Nanoparticles ◽  
Core Shell ◽  
Ph Responsive

Relationship between intracellular pH and ammonia metabolism in LLC-PK1 cells

1990 ◽  
Vol 258 (1) ◽  
pp. F103-F108 ◽  
Author(s):  
A. Sahai ◽  
E. Laughrey ◽  
R. L. Tannen
Keyword(s):  
Intracellular Ph ◽  
Cultured Cells ◽  
Ph Responsive ◽  
Bicarbonate Concentration ◽  
Acid Base ◽  
Ammonia Metabolism ◽  
Ph Changes ◽  
Concentration Measurements ◽  
Significant Change ◽  
Alanine Production

Previous studies from our laboratory have confirmed that cultures of LLC-PK1 cells exhibit pH-responsive alterations in ammonia metabolism produced by changes in media bicarbonate concentration. To further elucidate the mechanism of ammonia regulation, studies were carried out using parallel cultures of still and rocked LLC-PK1 cells subjected to acute alterations in media pH by either metabolic or respiratory acid-base manipulations. When media pH was altered by modifying PCO2 levels, the response of ammonia and alanine production by rocked culture was identical to the changes observed with metabolic acid-base maneuvers. Furthermore, both metabolic and respiratory acute acidosis resulted in a fall of intracellular alpha-ketoglutarate concentrations in these cells. In contrast, standard still cultures subjected to acute acidosis/alkalosis by metabolic and respiratory manipulations did not exert any significant change in ammonia and alanine production or in intracellular alpha-ketoglutarate concentration. Measurements of intracellular pH (pHi) by the 5,5-[2-14C]dimethyloxazolidine-2,4-dione method in rocked cells demonstrated changes in pHi parallel to media pH changes induced by both metabolic and respiratory acid-base maneuvers. Despite the absence of pH-responsive ammonia-genesis in still cultured cells the pHi values were altered in a fashion similar to their rocked counterparts, indicating the lack of an effect of the pHi signal on ammonia metabolism.

scholarly journals Water gated contrast switching with polymer–silica hybrid nanoparticles

2019 ◽  
Vol 55 (59) ◽  
pp. 8540-8543 ◽  
Author(s):  
Juan Pellico ◽  
Connor M. Ellis ◽  
Jack Miller ◽  
Jason J. Davis
Keyword(s):  
Hybrid Nanoparticles ◽  
Reversible Change ◽  
Ph Responsive ◽  
Polymer Conformation ◽  
Mri Contrast ◽  
Silica Hybrid

The polymeric capping of a paramagnetically doped MSN enables the generation of high T1 MRI contrast which is highly pH responsive through a fully reversible change in polymer conformation.

scholarly journals Glucosamine Modified the Surface of pH-Responsive Poly(2-(diethylamino)ethyl Methacrylate) Brushes Grafted on Hollow Mesoporous Silica Nanoparticles as Smart Nanocarrier

Polymers ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 2749 ◽  
Author(s):  
Abeer Beagan ◽  
Shatha Lahmadi ◽  
Ahlam Alghamdi ◽  
Majed Halwani ◽  
Mohammed Almeataq ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Hybrid Nanoparticles ◽  
Ph Responsive ◽  
Ethyl Methacrylate ◽  
Drug Concentrations ◽  
Cytotoxicity Studies ◽  
Hollow Mesoporous Silica ◽  
Mcf 7

This work presents the synthesis of pH-responsive poly(2-(diethylamino) ethyl methacrylate) (PDEAEMA) brushes anchored on hollow mesoporous silica nanoparticles (HMSN-PDEAEMA) via a surface-initiated ARGET ATRP technique. The average size of HMSNs was ca. 340 nm, with a 90 nm mesoporous silica shell. The dry thickness of grafted PDEAEMA brushes was estimated to be ca 30 nm, as estimated by SEM and TEM. The halogen group on the surface of PDEAMA brushes was successfully derivatized with glucosamine, as confirmed by XPS. The effect of pH on the size of the hybrid nanoparticles was investigated by DLS. The size of fabricated nanoparticle decreased from ca. 950 nm in acidic media to ca. 500 nm in basic media due to the deprotonation of tertiary amine in the PDEAEMA. The PDEAEMA modified HMSNs nanocarrier was efficiently loaded with doxorubicin (DOX) with a loading capacity of ca. 64%. DOX was released in a relatively controlled pH-triggered manner from hybrid nanoparticles. The cytotoxicity studies demonstrated that DOX@HMSN-PDEAEMA-Glucosamine showed a strong ability to kill breast cancer cells (MCF-7 and MCF-7/ADR) at low drug concentrations, in comparison to free DOX.

scholarly journals pH-Responsive Properties of Asymmetric Nanopapers of Nanofibrillated Cellulose

Nanomaterials ◽  
2020 ◽  
Vol 10 (7) ◽  
pp. 1380
Author(s):  
Maud Chemin ◽  
Baptiste Beaumal ◽  
Bernard Cathala ◽  
Ana Villares
Keyword(s):  
Carboxylic Acid ◽  
Reaction Times ◽  
Nanofibrillated Cellulose ◽  
Ph Responsive ◽  
Tempo Oxidation ◽  
Ph Changes ◽  
Charge Concentration ◽  
Amine Groups ◽  
Layer Composition ◽  
Electrostatic Repulsions

Inspired by plant movements driven by the arrangement of cellulose, we have fabricated nanopapers of nanofibrillated cellulose (NFC) showing actuation under pH changes. Bending was achieved by a concentration gradient of charged groups along the film thickness. Hence, the resulting nanopapers contained higher concentration of charged groups on one side of the film than on the opposite side, so that pH changes resulted in charge-dependent asymmetric deprotonation of the two layers. Electrostatic repulsions separate the nanofibers in the nanopaper, thus facilitating an asymmetric swelling and the subsequent expanding that results in bending. Nanofibrillated cellulose was modified by 2,2,6,6-tetramethylpiperidin-1-yloxyl radical (TEMPO) oxidation at two reaction times to get different surface concentrations of carboxylic acid groups. TEMPO-oxidized NFC was further chemically transformed into amine-modified NFC by amidation. The formation of graded nanopapers was accomplished by successive filtration of NFC dispersions with varying charge nature and/or concentration. The extent of bending was controlled by the charge concentration and the nanopaper thickness. The direction of bending was tuned by the layer composition (carboxylic acid or amine groups). In all cases, a steady-state was achieved within less than 25 s. This work opens new routes for the use of cellulosic materials as actuators.

A novel thermal and pH responsive drug delivery system based on ZnO@PNIPAM hybrid nanoparticles

2014 ◽  
Vol 45 ◽  
pp. 524-529 ◽  
Author(s):  
Licheng Tan ◽  
Jian Liu ◽  
Weihua Zhou ◽  
Junchao Wei ◽  
Zhiping Peng
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Hybrid Nanoparticles ◽  
Ph Responsive
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