Smart Design of a pH-Responsive System Based on pHLIP-Modified Magnetite Nanoparticles for Tumor MRI

2021 ◽  
Author(s):  
Alexander M. Demin ◽  
Alexandra G. Pershina ◽  
Artem S. Minin ◽  
Olga Ya. Brikunova ◽  
Aidar M. Murzakaev ◽  
...  
Keyword(s):  
Magnetite Nanoparticles ◽  
Ph Responsive ◽  
Tumor Mri

Magnetite nanoparticles as smart carriers to manipulate the cytotoxicity of anticancer drugs: magnetic control and pH-responsive release

2012 ◽  
Vol 22 (31) ◽  
pp. 15717 ◽  
Author(s):  
Zhenghuan Zhao ◽  
Dengtong Huang ◽  
Zhenyu Yin ◽  
Xiaoqin Chi ◽  
Xiaomin Wang ◽  
...  
Keyword(s):  
Anticancer Drugs ◽  
Magnetite Nanoparticles ◽  
Magnetic Control ◽  
Ph Responsive

scholarly journals pH-responsive poly(aspartic acid) hydrogel-coated magnetite nanoparticles for biomedical applications

2017 ◽  
Vol 77 ◽  
pp. 366-373 ◽  
Author(s):  
Jaime Vega-Chacón ◽  
María Isabel Amaya Arbeláez ◽  
Janaina Habib Jorge ◽  
Rodrigo Fernando C. Marques ◽  
Miguel Jafelicci
Keyword(s):  
Aspartic Acid ◽  
Magnetite Nanoparticles ◽  
Biomedical Applications ◽  
Ph Responsive

Nanostructures for pH-sensitive Drug Delivery and Magnetic Resonance Contrast Enhancement Systems

2018 ◽  
Vol 25 (25) ◽  
pp. 3036-3057 ◽  
Author(s):  
Xiao Sun ◽  
Guilong Zhang ◽  
Zhengyan Wu
Keyword(s):  
Drug Delivery ◽  
Magnetic Resonance ◽  
Drug Release ◽  
Contrast Enhancement ◽  
General Strategy ◽  
Ph Responsive ◽  
Physicochemical Changes ◽  
Magnetic Resonance Contrast ◽  
Resonance Contrast ◽  
Magnetic Resonance Contrast Enhancement

According to the differences of microenvironments between tumors and healthy tissues, if the anticancer drugs or magnetic resonance contrast agents (MRCAs) can be controlled to precisely match physiological needs at targeted tumor sites, it is expected to acquire better therapeutic efficacy and more accurate diagnosis. Over the decade, stimuli-responsive nanomaterials have been a research hotspot for cancer treatment and diagnosis because they show many excellent functions, such as in vivo imaging, combined targeting drug delivery and systemic controlled release, extended circulation time, etc. Among the various stimuli nanosystems, pH-stimuli mode is regarded as the most general strategy because of solid tumors acidosis. When exposed to weakly acidic tumor microenvironment, pH-responsive nanoplatforms can generate physicochemical changes for their structure and surface characteristics, causing drug release or contrast enhancement. In this review, we focused on the designs of various pH-responsive nanoplatforms and discussed the mechanisms of controlled drug release or switch on-off in MRCAs. This review also discussed the efficacy of cellular internalization for these nanoplatforms via endocytosis of acidic tumor cell. Meanwhile, nanoplatforms response to acidic intracellular pH (such as endosome, lysosome) are discussed, along with approaches for improving drug release performance and magnetic resonance contrast enhancement. A greater understanding of these pH-responsive nanoplatforms will help design more efficient nanomedicine to address the challenges encountered in conventional diagnosis and chemotherapy.

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