Metallic Oxide-Induced Self-Assembly of Block Copolymers to Form Polymeric Hybrid Micelles with Tunable Stability for Tumor Microenvironment-Responsive Drug Delivery

2021 ◽  
Author(s):  
Yalei Miao ◽  
Xiaoshuang Niu ◽  
Aijun Wu ◽  
Menghan Wu ◽  
Shengzhe Jin ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tumor Microenvironment ◽  
Block Copolymers ◽  
Self Assembly ◽  
Metallic Oxide

scholarly journals Polymerisation-induced self-assembly (PISA) as a straightforward formulation strategy for stimuli-responsive drug delivery systems and biomaterials: recent advances

2021 ◽  
Vol 9 (1) ◽  
pp. 38-50
Author(s):  
Hien Phan ◽  
Vincenzo Taresco ◽  
Jacques Penelle ◽  
Benoit Couturaud
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Drug Release ◽  
Self Assembly ◽  
Drug Delivery Systems ◽  
Amphiphilic Block Copolymers ◽  
Stimuli Responsive ◽  
Site Specific ◽  
On Demand ◽  
Redox Agents

Stimuli-responsive amphiphilic block copolymers obtained by PISA have emerged as promising nanocarriers for enhancing site-specific and on-demand drug release in response to a range of stimuli such as pH, redox agents, light or temperature.

On-demand shape transformation of polymer vesicles via site-specific isomerization of hydrazone photoswitches in monodisperse hydrophobic oligomers

2021 ◽  
Author(s):  
Valene Wang ◽  
Jiwon Kim ◽  
Junyoung Kim ◽  
Seul Woo Lee ◽  
Kyoung Taek Kim
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Conformational Change ◽  
Self Assembly ◽  
Shape Control ◽  
Shape Transformation ◽  
Site Specific ◽  
On Demand ◽  
Polymer Vesicles

The shape control of nanostructures formed by the solution self-assembly of block copolymers is of significance for drug delivery. In particular, site-specific perturbation resulting in the conformational change of the...

Design and self-assembly of albumin nanoclusters as a dynamic-covalent targeting co-delivery and stimuli-responsive controlled release platform

2018 ◽  
Vol 6 (42) ◽  
pp. 6817-6830 ◽  
Author(s):  
Wen Liu ◽  
Jian Dai ◽  
Wei Xue
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Tumor Microenvironment ◽  
Self Assembly ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Stimuli Responsive ◽  
Target Sites

Stimuli-responsive nanomaterial-based drug delivery systems that are able to actively target the tumor microenvironment, enhance intratumoral accumulation and release drugs at target sites are attractive therapeutic platforms at present.

scholarly journals Exploiting poly(α-hydroxy acids) for the acid-mediated release of doxorubicin and reversible inside–out nanoparticle self-assembly

Nanoscale ◽  
2018 ◽  
Vol 10 (29) ◽  
pp. 14201-14206 ◽  
Author(s):  
Mthulisi Khuphe ◽  
Nicola Ingram ◽  
Paul D. Thornton
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Self Assembly ◽  
Polymer Degradation ◽  
Hydroxy Acids ◽  
Ph Responsive ◽  
Hydroxyl Acid ◽  
Inside Out

Amphiphilic poly(hydroxyl acid) block copolymers are ideal candidates for the pH-responsive drug delivery via polymer degradation or polymer self-assembly/polymer disassembly.

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