scholarly journals Periodic Mesoporous Ionosilica Nanoparticles for Green Light Photodynamic Therapy and Photochemical Internalization of siRNA

2021 ◽  
Author(s):  
Braham Mezghrani ◽  
Lamiaa M. A. Ali ◽  
Sébastien Richeter ◽  
Jean-Olivier Durand ◽  
Peter Hesemann ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Green Light ◽  
Photochemical Internalization

Photochemical Internalization of Bleomycin is Superior to Photodynamic Therapy Due to the Therapeutic Effect in the Tumor Periphery

2009 ◽  
Vol 85 (3) ◽  
pp. 740-749 ◽  
Author(s):  
Ole-Jacob Norum ◽  
Jon-Vidar Gaustad ◽  
Even Angell-Petersen ◽  
Einar K. Rofstad ◽  
Qian Peng ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Therapeutic Effect ◽  
Photochemical Internalization ◽  
Tumor Periphery

Circumvention of resistance to photodynamic therapy in doxorubicin-resistant sarcoma by photochemical internalization of gelonin

2013 ◽  
Vol 65 ◽  
pp. 1300-1309 ◽  
Author(s):  
Cathrine Elisabeth Olsen ◽  
Kristian Berg ◽  
Pål Kristian Selbo ◽  
Anette Weyergang
Keyword(s):  
Photodynamic Therapy ◽  
Photochemical Internalization

scholarly journals Photodynamic Therapy for 101 Early Cancers of the Upper Aerodigestive Tract, the Esophagus, and the Bronchi: A Single-Institution Experience

1999 ◽  
Vol 5 (3) ◽  
pp. 145-154 ◽  
Author(s):  
A. Radu ◽  
P. Grosjean ◽  
Ch. Fontolliet ◽  
G. Wagnieres ◽  
A. Woodtli ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Early Stage ◽  
Red Light ◽  
Green Light ◽  
Tracheobronchial Tree ◽  
Aerodigestive Tract ◽  
Upper Aerodigestive Tract ◽  
Photofrin Ii ◽  
Significant Difference ◽  
Radical Therapy

Cancer, when detected at an early stage, has a very good probability of being eradicated by surgery or radiotherapy. However, less aggressive treatments also tend to provide high rates of cure without the side effects of radical therapy. We report on the results of our clinical experience with photodynamic therapy (PDT) for the treatment of early carcinomas in the upper aerodigestive tract, the esophagus, and the tracheobronchial tree. Sixty-four patients with 101 squamous cell carcinomas were treated with three different photosensitizers: hematoporphyrin derivative (HPD), Photofrin II, and tetra (m-hydroxyphenyl)chlorin (mTHPC). Seventy-seven (76%) tumors showed a complete rsponse with no recurrence after a mean follow-up period of 27 months. There was no significant difference in terms of cure rates among the three dyes. However, mTHPC has a stronger phototoxicity and induces a shorter skin photosensitization than either of the other photosensitizers. There were eight major complications: three esophagotracheal fistulae after illumination with red light in the esophagus, two esophageal stenoses following 360° circumferential irradiation, and three bronchial stenoses. Illumination with the less penetrating green light and the use of a 180° or 240° windowed cylindrical light distributor render the risk of complications in the esophagus essentially impossible, without reducing the efficacy of the treatment. Therefore, PDT may be considered as a safe and effective treatment for early carcinomas of the upper aerodigestive tract, the esophagus, and the tracheobronchial tree.

Intraperitoneal Photodynamic Therapy: Comparison of Red and Green Light Distribution and Toxicity

1997 ◽  
Vol 66 (3) ◽  
pp. 389-395 ◽  
Author(s):  
Ruth B. Veenhuizen ◽  
Marjan C. Ruevekamp ◽  
Hugo Oppelaar ◽  
Brigitte Ransdorp ◽  
Mark Vijver ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Green Light ◽  
Light Distribution

Green light is effective and less painful than red light in photodynamic therapy of facial solar keratoses

1997 ◽  
Vol 13 (5-6) ◽  
pp. 181-185 ◽  
Author(s):  
C. Fritsch ◽  
H. Stege ◽  
G. Saalmann ◽  
G. Goerz ◽  
T. Ruzicka ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Red Light ◽  
Green Light

scholarly journals Fricke Dosimetry as a Tool to Quality Control of Photodynamic Therapy

2019 ◽  
Vol 7 (3) ◽  
Author(s):  
SUZANA OLIVEIRA SANTOS ◽  
Vivianne L. B. Souza
Keyword(s):  
Quality Control ◽  
Photodynamic Therapy ◽  
Low Cost ◽  
Red Light ◽  
Green Light ◽  
Yellow Light ◽  
Light Emitting ◽  
Low Toxicity ◽  
Cellular Necrosis ◽  
Photosensitizing Agent

Photodynamic therapy (PDT) consists of the association of a photosensitizing agent with a light source in order to cause cellular necrosis. Methylene blue, toluidine blue and malachite green are photosensitizers derived from dyes that are widely accepted in medicine, as they have low toxicity and are low cost. PDT is an alternative treatment for cancer, with significant advantages over procedures such as surgery/chemotherapy. Our laboratory has studied the Fricke solution doped with photosensitizers in an approach to obtain a quality control for PDT. The Fricke solution was prepared with ammoniacal ferrous sulfate, sodium chloride and sulfuric acid in water. The solutions modified with photosensitizers were prepared by adding 0.1 g/100 mL of the dyes. A volume of 2.6 ml of the Fricke solution modified with photosensitizers were transferred to test tubes and irradiated. The irradiated solutions had their optical densities measured in a spectrophotometer. The samples were irradiated with LED (Light Emitting Diodes) in acrylic phantoms. The FATA samples irradiated with LED showed the sensitivity of the dosimeters to red, blue, green and yellow light. A calibration curve with correlation coefficient of 0.9884 for the red light was obtained; 0.9752 for blue light; 0.9644 for the green light and 0.9768 for the yellow light. The fact that a sensitivity of the dosimeters to the LED has been occurred indicates that the PDT could be realized with LED, with lower costs than with laser. This work suggested that FATA dosimeters can be used for quality control of PDT.

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