Size-Resolved Single Entity Collision Biosensing for Dual Quantification of MicroRNAs in a Single Run

2021 ◽  
Author(s):  
Yi-Yan Bai ◽  
Yan-Ju Yang ◽  
Zhen Wu ◽  
Xiao-Yan Yang ◽  
Miao Lin ◽  
...  
Keyword(s):  
Single Entity

scholarly journals THE ECONOMIST AS SCIENTIST, ENGINEER, OR PLUMBER?

2021 ◽  
Vol 43 (2) ◽  
pp. 297-312
Author(s):  
Huei-Chun Su ◽  
David Colander
Keyword(s):  
Radical Change ◽  
Economic Science ◽  
Single Entity ◽  
General Contractor

Some well-known economists suggest that a good economist should act like an engineer, a surgeon, a dentist, or even a plumber. These metaphors are useful in helping economists reflect the nature of economics and their role in society. But which is the most sensible one? This paper argues that economists should be playing all these roles and more, because economics is not a single entity, and each entity has separate goals, methods, and boundaries. To take this multiplicity of roles into account, this paper argues that in addition to the traditional boundary that delineates the disciplinary domain of economics against other sciences, an overarching boundary between economic science and applied policy needs to be recognized. It then examines Esther Duflo’s “economist as plumber” metaphor and suggests that a better metaphor for Duflo’s purpose would be “general contractor,” a metaphor that, if accepted, would suggest radical change in training applied policy economists.

scholarly journals How to talk with the family of a dying patient: anger to understanding, rage to compassion, loss to acceptance

2021 ◽  
pp. bmjspcare-2021-002971
Author(s):  
Moshe Y Flugelman
Keyword(s):  
Goal Setting ◽  
Stressful Situation ◽  
Family Needs ◽  
The Third ◽  
Single Entity ◽  
The Family ◽  
Patient Families ◽  
The Difference ◽  
Dying Patient

Informing families about the impending or actual death of their relatives is one of the most challenging and complex tasks a physician may face. The following article describes goal setting and provides five roles/recommendations for conducting the encounter with patient families regarding the imminent or actual death of their relatives. Importantly, the encounter should be family-centred, and the physician should be highly attentive to family needs. The following roles should be applied based on family needs and should not be sequential as numbered. The first and basic role is to inform the family at the earliest possible time and as often as possible. The second goal of the physician is to convey to the family that their relative received the needed therapy during his hospitalisation or in the community. The third goal of the physician is to help the family reach acceptance of the death of their relative and leave the hospital having moved beyond anger and bargaining. The fourth goal of the physician during the encounters is to reduce or alleviate guilt by stating that nothing could have changed the course of the disease and that all efforts were made to save the patient. The fifth role of the physician is to try and help the family as a single entity and maintain their unity during this stressful situation. Following these roles/methods will help families in the stressful situation and will create the difference between anger and understanding, rage and compassion, and loss and acceptance.

The corticotrophic cells of the canine pituitary gland in pituitary-dependent hyperadrenocorticism

1983 ◽  
Vol 96 (2) ◽  
pp. 303-309 ◽  
Author(s):  
A. M. McNicol ◽  
H. Thomson ◽  
C. J. R. Stewart
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Pituitary Gland ◽  
Cushing’S Disease ◽  
Cushing's Disease ◽  
Human Pituitary ◽  
Human Pituitary Gland ◽  
Single Entity ◽  
Pituitary Glands ◽  
Corticotrophic Cells

The distribution of specifically stained corticotrophic cells has been studied in the pituitary glands of 11 dogs with pituitary-dependent hyperadrenocorticism. The results suggest that the disease is not a single entity, and that some cases are caused by primary abnormality of the pituitary gland whereas others appear to be the result of dysfunction of the hypothalamus or central nervous system. The patterns correspond closely to those demonstrated in the human pituitary gland in Cushing's disease, and confirm that the canine disease is a useful model for the study of the pathogenesis of the variants of the condition.

Linea Vestibularis: A Previously Undescribed Normal Genital Structure in Female Neonates

PEDIATRICS ◽  
1991 ◽  
Vol 87 (6) ◽  
pp. 926-929
Author(s):  
NANCY D. KELLOGG ◽  
JUAN M. PARRA
Keyword(s):  
Sexual Abuse ◽  
Anatomical Variations ◽  
White Area ◽  
Multiple Lesions ◽  
Single Entity ◽  
Female Children ◽  
Genital Structure

The increasing number of evidentiary examinations conducted for sexual abuse has accentuated the importance of defining normal genital anatomy, particularly within the vestibule of female children. In female newborns, normal anatomical variations of the hymen have been described1,2 but anatomical variations of the posterior vestibule underlying the hymen have not been reported. In children evaluated for sexual abuse a vestibular structure of varying description and location has been reported. A "midline avascular streak," "scar," and "a white area" have been noted in the posterior vestibule, posterior fourchette, and hymen.1,3,4 Whether these descriptions all pertain to a single entity or are multiple lesions is not known.

scholarly journals Effects of Paroxetine, a CYP2D6 Inhibitor, on the Pharmacokinetic Properties of Hydrocodone After Coadministration With a Single-entity, Once-daily, Extended-release Hydrocodone Tablet

2015 ◽  
Vol 37 (10) ◽  
pp. 2286-2296 ◽  
Author(s):  
Ram P. Kapil ◽  
Kristen Friedman ◽  
Alessandra Cipriano ◽  
Gregory Michels ◽  
Manjunath Shet ◽  
...  
Keyword(s):  
Extended Release ◽  
Once Daily ◽  
Single Entity ◽  
Pharmacokinetic Properties

scholarly journals Analysis of Single-entity Anisotropy with a Solid-state Nanopore

2017 ◽  
Vol 75 (7) ◽  
pp. 675 ◽  
Author(s):  
Yao Lin ◽  
Yilun Ying ◽  
Rui Gao ◽  
Huifeng Wang ◽  
Yitao Long
Keyword(s):  
Solid State ◽  
Single Entity

scholarly journals An Event-Related Brain Potential (ERP) Study of Complex Anaphora in Spanish

2021 ◽  
Vol 12 ◽  
Author(s):  
Adrián García-Sierra ◽  
Juan Silva-Pereyra ◽  
Graciela Catalina Alatorre-Cruz ◽  
Noelle Wig
Keyword(s):  
Sentence Processing ◽  
Short Term Memory ◽  
Event Related Potentials ◽  
Cognitive Resources ◽  
Brain Potential ◽  
Single Entity ◽  
Demonstrative Pronouns ◽  
Frontal Negativity ◽  
Related Potentials ◽  
Anterior Negativity

This study examines the event- related brain potential (ERP) of 25 Mexican monolingual Spanish-speakers when reading Spanish sentences with single entity anaphora or complex anaphora. Complex anaphora is an expression that refer to propositions, states, facts or events while, a single entity anaphora is an expression that refers back to a concrete object. Here we compare the cognitive cost in processing a single entity anaphora [éstafeminine; La renuncia (resignation)] from a complex anaphora [estoneuter; La renuncia fue aceptada (The resignation was accepted)]. Ésta elicited a larger positive peak at 200 ms, and esto elicited a larger frontal negativity around 400 ms. The positivity resembles the P200 component, and its amplitude is thought to represent an interaction between predictive qualities in sentence processing (i.e., graphical similarity and frequency of occurrence). Unlike parietal negativities (typical N400), frontal negativities are thought to represent the ease by which pronouns are linked with its antecedent, and how easy the information is recovered from short-term memory. Thus, the complex anaphora recruited more cognitive resources than the single entity anaphora. We also included an ungrammatical control sentence [éstemasculine; La renuncia (resignation)] to better understand the unique processes behind complex anaphoric resolution, as opposed to just general difficulty in sentence processing. In this case, event-related potentials (ERPs) elicited by éstemasculine and éstafeminine were compared. Again, ésta elicited a larger P200. However, different from the experimental condition, a left anterior negativity (LAN) effect was observed for éste; the ungrammatical condition. Altogether, the present research provides electrophysiological evidence indicating that demonstrative pronouns with different morphosyntactic features (i.e., gender) and discourse parameters (i.e., single entity or complex referent) interact during the first stage of anaphoric processing of anaphora. This stage initiated as early as 200 milliseconds after the pronoun onset and probably ends around 400 ms.

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