Optimized Combination of Photodynamic Therapy and Chemotherapy Using Gelatin Nanoparticles Containing Tirapazamine and Pheophorbide a

2021 ◽  
Vol 13 (9) ◽  
pp. 10812-10821
Author(s):  
Donghyun Lee ◽  
Seok-young Jang ◽  
Soonmin Kwon ◽  
Yeeun Lee ◽  
Eunyoung Park ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Pheophorbide A ◽  
Gelatin Nanoparticles

scholarly journals Pheophorbide a: State of the Art

Marine Drugs ◽  
2020 ◽  
Vol 18 (5) ◽  
pp. 257 ◽  
Author(s):  
Assunta Saide ◽  
Chiara Lauritano ◽  
Adrianna Ianora
Keyword(s):  
Clinical Trials ◽  
Photodynamic Therapy ◽  
Anticancer Activity ◽  
State Of The Art ◽  
Human Cancer ◽  
Human Cancer Cell ◽  
Pheophorbide A ◽  
Human Cancer Cell Lines ◽  
Chlorophyll Breakdown ◽  
Chlorophyll Derivative

Chlorophyll breakdown products are usually studied for their antioxidant and anti-inflammatory activities. The chlorophyll derivative Pheophorbide a (PPBa) is a photosensitizer that can induce significant anti-proliferative effects in several human cancer cell lines. Cancer is a leading cause of death worldwide, accounting for about 9.6 million deaths, in 2018 alone. Hence, it is crucial to monitor emergent compounds that show significant anticancer activity and advance them into clinical trials. In this review, we analyze the anticancer activity of PPBa with or without photodynamic therapy and also conjugated with or without other chemotherapic drugs, highlighting the capacity of PPBa to overcome multidrug resistance. We also report other activities of PPBa and different pathways that it can activate, showing its possible applications for the treatment of human pathologies.

Oxime-based 19-nortestosterone–pheophorbide a conjugate: bimodal controlled release concept for PDT

2019 ◽  
Vol 7 (36) ◽  
pp. 5465-5477 ◽  
Author(s):  
Vladimíra Pavlíčková ◽  
Michal Jurášek ◽  
Silvie Rimpelová ◽  
Kamil Záruba ◽  
David Sedlák ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Androgen Receptor ◽  
Controlled Release ◽  
Cancer Cells ◽  
Pheophorbide A

Nandrolone–pheophorbide a fluorescent conjugate exhibiting promising potential in targeting of androgen receptor-positive cancer cells and their destruction by photodynamic therapy.

scholarly journals Pheophorbide a as a photosensitizer in photodynamic therapy: In vivo considerations

2009 ◽  
Vol 8 (6) ◽  
pp. 540-542 ◽  
Author(s):  
Theresa Busch ◽  
Keith A. Cengel ◽  
Jarod Finlay
Keyword(s):  
Photodynamic Therapy ◽  
Pheophorbide A

scholarly journals The Sensitivity of Cancer Cells to Pheophorbide a-Based Photodynamic Therapy Is Enhanced by NRF2 Silencing

PLoS ONE ◽  
2014 ◽  
Vol 9 (9) ◽  
pp. e107158 ◽  
Author(s):  
Bo-hyun Choi ◽  
In-geun Ryoo ◽  
Han Chang Kang ◽  
Mi-Kyoung Kwak
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Pheophorbide A

GSH-mediated photoactivity of pheophorbide a-conjugated heparin/gold nanoparticle for photodynamic therapy

2013 ◽  
Vol 171 (2) ◽  
pp. 241-250 ◽  
Author(s):  
Li Li ◽  
Md. Nurunnabi ◽  
Md. Nafiujjaman ◽  
Yong-kyu Lee ◽  
Kang Moo Huh
Keyword(s):  
Photodynamic Therapy ◽  
Gold Nanoparticle ◽  
Pheophorbide A

scholarly journals Pheophorbide a based photodynamic therapy induces apoptosis via mitochondrial-mediated pathway in human uterine carcinosarcoma

2009 ◽  
Vol 8 (6) ◽  
pp. 533-539 ◽  
Author(s):  
Patrick Ming-Kuen Tang ◽  
Xiao-Zhuo Liu ◽  
Dong-Mei Zhang ◽  
Wing-Ping Fong ◽  
Kwok-Pui Fung
Keyword(s):  
Photodynamic Therapy ◽  
Uterine Carcinosarcoma ◽  
Pheophorbide A

Chemical modification of chlorophyll a: synthesis of new regiochemically pure benzoporphyrin and dibenzoporphyrin derivatives

1997 ◽  
Vol 75 (3) ◽  
pp. 262-275 ◽  
Author(s):  
Lifu Ma ◽  
David Dolphin
Keyword(s):  
Photodynamic Therapy ◽  
Methyl Ester ◽  
Chemical Modification ◽  
Chlorophyll A ◽  
Degradation Product ◽  
Diels Alder ◽  
Dimethyl Acetylenedicarboxylate ◽  
Pheophorbide A ◽  
Potential Use

Starting from pheophorbide a methyl ester (5), a degradation product of chlorophyll a, routes for the preparation of 3-vinylporphyrins 6 and 9 and of an [A,C]-divinylporphyrin 16 are described. These porphyrins were obtained as a result of chemical modification of 5 on ring D and the exocyclic ring E. Diels–Alder reactions of these (di)vinylporphyrins with dimethyl acetylenedicarboxylate, to afford new regiochemically pure benzoporphyrin derivatives 29 and 30 and dibenzoporphyrin derivative 33 for potential use as sensitizers in photodynamic therapy of tumors, were also investigated. Keywords: Diels–Alder, (di)vinylporphyrins, (di)benzoporphyrins, photodynamic therapy, chlorophyll.

Monomeric pheophorbide(a)-containing poly(ethyleneglycol-b-ε-caprolactone) micelles for photodynamic therapy

2009 ◽  
Vol 8 (3) ◽  
pp. 396 ◽  
Author(s):  
Katrin Knop ◽  
Anne-Françoise Mingotaud ◽  
Naram El-Akra ◽  
Frédéric Violleau ◽  
Jean-Pierre Souchard
Keyword(s):  
Photodynamic Therapy ◽  
Pheophorbide A
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