Calcium Carbonate Core–Shell Particles for Incorporation of 225Ac and Their Application in Local α-Radionuclide Therapy

Author(s):  
Albert R. Muslimov ◽  
Dmitrii O. Antuganov ◽  
Yana V. Tarakanchikova ◽  
Mikhail V. Zhukov ◽  
Michail A. Nadporojskii ◽  
...  
2006 ◽  
Vol 988 ◽  
Author(s):  
Yi-Yeoun Kim ◽  
John W Catino ◽  
Gary P Tomaino ◽  
Sherman D Cox

AbstractIn this report, we present a bio-inspired encapsulation process to create nanocluster-assembled core-shell particles under aqueous, room temperature and non-toxic conditions. The approach to synthesize calcium carbonate core-shell particles is accomplished by employing a Polymer-Induced Liquid-Precursor (PILP) process. We demonstrate the amorphous mineral precursor is coated around a core of hydrogel nanoparticles, and subsequently solidified and crystallized. The synthesized core-shell particles are 300∼500nm diameter and ∼100 nm shell-thickness. We investigate the role of the hydrogel core of the particle using time-resolved XRD, thermal-XRD and thermal analysis. The organic hydrogel appears to influence the transformation of mineral phases, stabilizing the amorphous phase of calcium carbonate.


2020 ◽  
Vol 10 (23) ◽  
pp. 8551
Author(s):  
Mark A. Bewernitz ◽  
Archana C. Lovett ◽  
Laurie B. Gower

Micron-sized core-shell particles consisting of a calcium carbonate (CaCO3) mineral shell and a fluidic core were generated using a biomimetic approach, for the purpose of use as biodegradable microcapsules for release of active agents. Dinoflagellate cysts, unicellular organisms which deposit a protective hard mineral shell around their soft and fluidic cellular interior, served as our inspiration. Using the biomimetic polymer-induced liquid-precursor (PILP) mineralization process, calcium carbonate coatings were deposited on charged emulsion droplets and liposomes. Light microscopy, scanning electron microscopy, polarized light microscopy, X-ray diffraction, and confocal fluorescence microscopy were used to demonstrate that smooth CaCO3 mineral coatings can be deposited onto the high curvature surfaces of emulsions and liposomes to yield micron-sized microcapsules for the effective entrapment of both hydrophobic and hydrophilic active agents. These biodegradable and biocompatible CaCO3 microcapsules are novel systems for producing a powdered form of fluid-containing capsules for storage and transport of pharma/chemical agents. They may be used in lieu of, or in conjunction with, existing microcapsule delivery approaches, as well as providing a convenient foundation for which polymeric coatings could be further applied, allowing for more complex targeting and/or chemical-release control.


2020 ◽  
Vol 65 (10) ◽  
pp. 904
Author(s):  
V. O. Zamorskyi ◽  
Ya. M. Lytvynenko ◽  
A. M. Pogorily ◽  
A. I. Tovstolytkin ◽  
S. O. Solopan ◽  
...  

Magnetic properties of the sets of Fe3O4(core)/CoFe2O4(shell) composite nanoparticles with a core diameter of about 6.3 nm and various shell thicknesses (0, 1.0, and 2.5 nm), as well as the mixtures of Fe3O4 and CoFe2O4 nanoparticles taken in the ratios corresponding to the core/shell material contents in the former case, have been studied. The results of magnetic research showed that the coating of magnetic nanoparticles with a shell gives rise to the appearance of two simultaneous effects: the modification of the core/shell interface parameters and the parameter change in both the nanoparticle’s core and shell themselves. As a result, the core/shell particles acquire new characteristics that are inherent neither to Fe3O4 nor to CoFe2O4. The obtained results open the way to the optimization and adaptation of the parameters of the core/shell spinel-ferrite-based nanoparticles for their application in various technological and biomedical domains.


2008 ◽  
Vol 20 (4) ◽  
pp. 1292-1298 ◽  
Author(s):  
M. P. L. Werts ◽  
M. Badila ◽  
C. Brochon ◽  
A. Hébraud ◽  
G. Hadziioannou

Nano Letters ◽  
2014 ◽  
Vol 14 (4) ◽  
pp. 2140-2149 ◽  
Author(s):  
Maria E. Stournara ◽  
Yue Qi ◽  
Vivek B. Shenoy

2016 ◽  
Vol 8 (15) ◽  
pp. 3061-3068 ◽  
Author(s):  
Christina Meisenbichler ◽  
Julia S. Rauch ◽  
Yüksel Güzel ◽  
Eva-Maria Wernig ◽  
Dieter Schemeth ◽  
...  

Selective enrichment of phosphorylated peptides by magnetic ytterbium oxide core-shell particles.


2005 ◽  
Vol 84 (1-3) ◽  
pp. 254-260 ◽  
Author(s):  
Jimin Du ◽  
Zhimin Liu ◽  
Buxing Han ◽  
Zhonghao Li ◽  
Jianling Zhang ◽  
...  

2007 ◽  
Vol 104 (2) ◽  
pp. 1195-1199 ◽  
Author(s):  
Jing Wang ◽  
Ya-qing Feng ◽  
Jun-wei Guo ◽  
Yu-kun Li ◽  
Xiang-gao Li
Keyword(s):  

Sign in / Sign up

Export Citation Format

Share Document