Targeted Regulation of Blood–Brain Barrier for Enhanced Therapeutic Efficiency of Hypoxia-Modifier Nanoparticles and Immune Checkpoint Blockade Antibodies for Glioblastoma

2021 ◽  
Vol 13 (10) ◽  
pp. 11657-11671
Author(s):  
Lingtong Meng ◽  
Cuirong Wang ◽  
Yaping Lu ◽  
Gang Sheng ◽  
Lin Yang ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Immune Checkpoint ◽  
Immune Checkpoint Blockade ◽  
Checkpoint Blockade ◽  
Brain Barrier ◽  
Therapeutic Efficiency ◽  
Blood Brain ◽  
Immune Checkpoint Blockade Antibodies

Intracranial response after extracranial radiation in a patient with rapidly progressing metastatic melanoma

2021 ◽  
Vol 14 (6) ◽  
pp. e240921
Author(s):  
Oliver Piercey ◽  
Jonathan Mark Tomaszewski ◽  
Kortnye Smith
Keyword(s):  
Metastatic Melanoma ◽  
Blood Brain Barrier ◽  
Metabolic Response ◽  
Immune Checkpoint Blockade ◽  
Brain Barrier ◽  
Abscopal Effect ◽  
Complete Metabolic Response ◽  
Immunological Responses ◽  
Metastatic Lesions ◽  
Blood Brain

Growing literature supports the synergistic effect of radiation as a primer for renewed enhanced systemic immunological responses in patients receiving immunotherapy for metastatic melanoma. Radiographic regression of extracranial tumours after treatment of intracranial metastatic lesions has been reported and these observations point to an abscopal effect that traverses the blood–brain barrier. We describe a patient with rapidly progressing metastatic melanoma despite combined immune checkpoint blockade, who achieved a complete metabolic response of both his extracranial and intracranial disease after the commencement of palliative radiation to his axilla. This is the first published case, to our knowledge, of a sustained, complete intracranial abscopal response from extracranial radiation. We discuss potential mechanistic relations between radiation, the blood–brain barrier and the abscopal effect.

scholarly journals Implantable optical fibers for immunotherapeutics delivery and tumor impedance measurement

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Ai Lin Chin ◽  
Shan Jiang ◽  
Eungyo Jang ◽  
Liqian Niu ◽  
Liwu Li ◽  
...  
Keyword(s):  
Optical Fibers ◽  
Immune Checkpoint ◽  
Impedance Measurement ◽  
Immune Checkpoint Blockade ◽  
Drug Dose ◽  
Checkpoint Blockade ◽  
Patient Response ◽  
Multiple Tumor ◽  
Delivery Strategies ◽  
Immune Checkpoint Blockade Antibodies

AbstractImmune checkpoint blockade antibodies have promising clinical applications but suffer from disadvantages such as severe toxicities and moderate patient–response rates. None of the current delivery strategies, including local administration aiming to avoid systemic toxicities, can sustainably supply drugs over the course of weeks; adjustment of drug dose, either to lower systemic toxicities or to augment therapeutic response, is not possible. Herein, we develop an implantable miniaturized device using electrode-embedded optical fibers with both local delivery and measurement capabilities over the course of a few weeks. The combination of local immune checkpoint blockade antibodies delivery via this device with photodynamic therapy elicits a sustained anti-tumor immunity in multiple tumor models. Our device uses tumor impedance measurement for timely presentation of treatment outcomes, and allows modifications to the delivered drugs and their concentrations, rendering this device potentially useful for on-demand delivery of potent immunotherapeutics without exacerbating toxicities.

Conformationally Constrained Peptide Drugs Targeted at the Blood-Brain Barrier

1995 ◽  
Author(s):  
Thomas P. Davis ◽  
Thomas J. Abbruscato ◽  
Elizabeth Brownson ◽  
Victor J. Hruby
Keyword(s):  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Peptide Drugs ◽  
Conformationally Constrained ◽  
Blood Brain
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