NIR-Controlled Treatment of Multidrug-Resistant Tumor Cells by Mesoporous Silica Capsules Containing Gold Nanorods and Doxorubicin

2021 ◽  
Author(s):  
Xue Yang ◽  
Man Li ◽  
Jinying Liang ◽  
Xueyan Hou ◽  
Xiaoxiao He ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Tumor Cells ◽  
Gold Nanorods ◽  
Multidrug Resistant ◽  
Controlled Treatment

scholarly journals Gene-Directed Enzyme Prodrug Therapy by Dendrimer-Like Mesoporous Silica Nanoparticles against Tumor Cells

Nanomaterials ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 1298
Author(s):  
Vicente Candela-Noguera ◽  
Gema Vivo-Llorca ◽  
Borja Díaz de Greñu ◽  
María Alfonso ◽  
Elena Aznar ◽  
...  
Keyword(s):  
Cell Death ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Tumor Cells ◽  
Mesoporous Silica Nanoparticles ◽  
Combined Treatment ◽  
Bond Rupture ◽  
Enzyme Prodrug Therapy ◽  
Bacterial Gene ◽  
Reducing Environment

We report herein a gene-directed enzyme prodrug therapy (GDEPT) system using gated mesoporous silica nanoparticles (MSNs) in an attempt to combine the reduction of side effects characteristic of GDEPT with improved pharmacokinetics promoted by gated MSNs. The system consists of the transfection of cancer cells with a plasmid controlled by the cytomegalovirus promoter, which promotes β-galactosidase (β-gal) expression from the bacterial gene lacZ (CMV-lacZ). Moreover, dendrimer-like mesoporous silica nanoparticles (DMSNs) are loaded with the prodrug doxorubicin modified with a galactose unit through a self-immolative group (DOXO-Gal) and modified with a disulfide-containing polyethyleneglycol gatekeeper. Once in tumor cells, the reducing environment induces disulfide bond rupture in the gatekeeper with the subsequent DOXO-Gal delivery, which is enzymatically converted by β-gal into the cytotoxic doxorubicin drug, causing cell death. The combined treatment of the pair enzyme/DMSNs-prodrug are more effective in killing cells than the free prodrug DOXO-Gal alone in cells transfected with β-gal.

Janus Mesoporous Silica Nanoparticles for Dual Targeting of Tumor Cells and Mitochondria

2017 ◽  
Vol 9 (32) ◽  
pp. 26697-26706 ◽  
Author(s):  
Victoria López ◽  
Maria Rocío Villegas ◽  
Verónica Rodríguez ◽  
Gonzalo Villaverde ◽  
Daniel Lozano ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Tumor Cells ◽  
Mesoporous Silica Nanoparticles ◽  
Dual Targeting

scholarly journals Multiple-Responsive Mesoporous Silica Nanoparticles for Highly Accurate Drugs Delivery to Tumor Cells

ACS Omega ◽  
2018 ◽  
Vol 3 (4) ◽  
pp. 4306-4315 ◽  
Author(s):  
Ronghua Jin ◽  
Zhongning Liu ◽  
Yongkang Bai ◽  
Yongsheng Zhou ◽  
Xin Chen
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Tumor Cells ◽  
Mesoporous Silica Nanoparticles

Expression of the IAPs in multidrug resistant tumor cells

2004 ◽  
Author(s):  
Monica Notarbartolo ◽  
Melchiorre Cervello ◽  
Paola Poma ◽  
Luisa Dusonchet ◽  
Maria Meli ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Multidrug Resistant

scholarly journals Mesoporous silica-coated gold nanorods with embedded indocyanine green for dual mode X-ray CT and NIR fluorescence imaging

2011 ◽  
Vol 19 (18) ◽  
pp. 17030 ◽  
Author(s):  
Teng Luo ◽  
Peng Huang ◽  
Guo Gao ◽  
Guangxia Shen ◽  
Shen Fu ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Indocyanine Green ◽  
Fluorescence Imaging ◽  
Gold Nanorods ◽  
Dual Mode ◽  
X Ray ◽  
Nir Fluorescence

High-Performance Dual Combination Therapy for Cancer Treatment with Hybrid Membrane-Camouflaged Mesoporous Silica Gold Nanorods

2020 ◽  
Vol 12 (52) ◽  
pp. 57732-57745
Author(s):  
Huan Li ◽  
Qingsheng Peng ◽  
Langyu Yang ◽  
Yinshan Lin ◽  
Sheng Chen ◽  
...  
Keyword(s):  
Combination Therapy ◽  
Mesoporous Silica ◽  
Cancer Treatment ◽  
Gold Nanorods ◽  
High Performance ◽  
Hybrid Membrane
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