Injectable Adhesive Self-Healing Multicross-Linked Double-Network Hydrogel Facilitates Full-Thickness Skin Wound Healing

2020 ◽  
Vol 12 (52) ◽  
pp. 57782-57797
Author(s):  
Bo Yang ◽  
Jiliang Song ◽  
Yuhang Jiang ◽  
Ming Li ◽  
Jingjing Wei ◽  
...  
Keyword(s):  
Wound Healing ◽  
Skin Wound ◽  
Self Healing ◽  
Full Thickness ◽  
Skin Wound Healing ◽  
Double Network ◽  
Full Thickness Skin ◽  
Thickness Skin

scholarly journals Pharmaceutical application of frog skin on full-thickness skin wound healing in mice

2013 ◽  
Vol 51 (12) ◽  
pp. 1600-1606 ◽  
Author(s):  
Mahere Rezazade Bazaz ◽  
Mohammad Mashreghi ◽  
Nasser Mahdavi Shahri ◽  
Mansour Mashreghi ◽  
Ahmad Asoodeh ◽  
...  
Keyword(s):  
Wound Healing ◽  
Frog Skin ◽  
Skin Wound ◽  
Full Thickness ◽  
Skin Wound Healing ◽  
Full Thickness Skin ◽  
Pharmaceutical Application ◽  
Thickness Skin

Comparison of five dermal substitutes in full-thickness skin wound healing in a porcine model

Burns ◽  
2012 ◽  
Vol 38 (6) ◽  
pp. 820-829 ◽  
Author(s):  
Cécile Philandrianos ◽  
Lucile Andrac-Meyer ◽  
Serge Mordon ◽  
Jean-Marc Feuerstein ◽  
Florence Sabatier ◽  
...  
Keyword(s):  
Wound Healing ◽  
Porcine Model ◽  
Skin Wound ◽  
Full Thickness ◽  
Skin Wound Healing ◽  
Dermal Substitutes ◽  
Full Thickness Skin ◽  
Thickness Skin

scholarly journals Large full-thickness wounded skin regeneration using 3D-printed elastic scaffold with minimal functional unit of skin

2022 ◽  
Vol 13 ◽  
pp. 204173142110630
Author(s):  
Peng Chang ◽  
Shijie Li ◽  
Qian Sun ◽  
Kai Guo ◽  
Heran Wang ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Wound Healing ◽  
Functional Unit ◽  
Collagen Gel ◽  
Skin Wound ◽  
Full Thickness ◽  
Skin Wound Healing ◽  
Full Thickness Skin ◽  
Thickness Skin ◽  
3D Printed

Traditional tissue engineering skin are composed of living cells and natural or synthetic scaffold. Besize the time delay and the risk of contamination involved with cell culture, the lack of autologous cell source and the persistence of allogeneic cells in heterologous grafts have limited its application. This study shows a novel tissue engineering functional skin by carrying minimal functional unit of skin (MFUS) in 3D-printed polylactide-co-caprolactone (PLCL) scaffold and collagen gel (PLCL + Col + MFUS). MFUS is full-layer micro skin harvested from rat autologous tail skin. 3D-printed PLCL elastic scaffold has the similar mechanical properties with rat skin which provides a suitable environment for MFUS growing and enhances the skin wound healing. Four large full-thickness skin defects with 30 mm diameter of each wound are created in rat dorsal skin, and treated either with tissue engineering functional skin (PLCL + Col + MFUS), or with 3D-printed PLCL scaffold and collagen gel (PLCL + Col), or with micro skin islands only (Micro skin), or without treatment (Normal healing). The wound treated with PLCL + Col + MFUS heales much faster than the other three groups as evidenced by the fibroblasts migration from fascia to the gap between the MFUS dermis layer, and functional skin with hair follicles and sebaceous gland has been regenerated. The PLCL + Col treated wound heals faster than normal healing wound, but no skin appendages formed in PLCL + Col-treated wound. The wound treated with micro skin islands heals slower than the wounds treated either with tissue engineering skin (PLCL + Col + MFUS) or with PLCL + Col gel. Our results provide a new strategy to use autologous MFUS instead “seed cells” as the bio-resource of engineering skin for large full-thickness skin wound healing.

Application of acellular intima from porcine thoracic aorta in full-thickness skin wound healing in a rat model

2017 ◽  
Vol 71 ◽  
pp. 1135-1144 ◽  
Author(s):  
Haitian Fu ◽  
Liping Teng ◽  
RuiZhen Bai ◽  
Chao Deng ◽  
Guozhong Lv ◽  
...  
Keyword(s):  
Wound Healing ◽  
Thoracic Aorta ◽  
Rat Model ◽  
Skin Wound ◽  
Full Thickness ◽  
Skin Wound Healing ◽  
Full Thickness Skin ◽  
Thickness Skin

scholarly journals Comparison of the Therapeutic Effects of Native and Anionic Nanofibrillar Cellulose Hydrogels for Full-Thickness Skin Wound Healing

Micro ◽  
2021 ◽  
Vol 1 (2) ◽  
pp. 194-214
Author(s):  
Raili Koivuniemi ◽  
Qian Xu ◽  
Jasmi Snirvi ◽  
Irene Lara-Sáez ◽  
Arto Merivaara ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Wound Healing ◽  
Early Stage ◽  
Skin Wound ◽  
Therapeutic Effects ◽  
Full Thickness ◽  
Skin Wound Healing ◽  
Full Thickness Skin ◽  
Nanofibrillar Cellulose ◽  
Thickness Skin

Nanofibrillar cellulose (NFC)-derived dressings such as films, hydrogels, and aerogels are one of the favorable materials for wound healing due to their proper mechanical properties and water holding ability. However, the therapeutic differences between native and anionic NFC materials are rarely studied. In this report, we compared the differences and addressed the regenerative potential of native and anionic wood-derived NFC hydrogels for wound treatment. In vitro characteristics of the hydrogels were detected using scanning electron microscopy, rheological measurements, and swelling and hemolytic activity assays. Skin regeneration at an early stage after hydrogel treatment was analyzed using an in vivo splinted excisional full-thickness skin wound model in C57BL/6 mice. Both native NFC and anionic NFC (ANFC) hydrogel with differing mechanical and surface properties were shown to be biocompatible. Surprisingly, wounds treated with NFC and ANFC hydrogel did not show any statistical difference compared with control wounds and progressed through normal wound closure, inflammatory response, re-epithelialization, vascularization, and tissue maturation with no signs of fibrosis. The data show here for the first time the therapeutic performance of native and anionic NFC hydrogel in a wound mimicking human wound healing mechanisms. The mechanical properties of native and anionic NFC hydrogels such as the capability to modify material stiffness may also prove to be valuable in the management of wounds in the future.

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