Functionalized GO Nanovehicles with Nitric Oxide Release and Photothermal Activity-Based Hydrogels for Bacteria-Infected Wound Healing

2020 ◽  
Author(s):  
Shaoshan Huang ◽  
Huiling Liu ◽  
Kedan Liao ◽  
Qinqin Hu ◽  
Rui Guo ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Wound Healing ◽  
Infected Wound ◽  
Nitric Oxide Release

Functionalized MoS2Nanovehicle with Near-Infrared Laser-Mediated Nitric Oxide Release and Photothermal Activities for Advanced Bacteria-Infected Wound Therapy

Small ◽  
2018 ◽  
Vol 14 (45) ◽  
pp. 1802290 ◽  
Author(s):  
Qin Gao ◽  
Xiao Zhang ◽  
Wenyan Yin ◽  
Dongqing Ma ◽  
Changjian Xie ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Near Infrared ◽  
Infrared Laser ◽  
Infected Wound ◽  
Wound Therapy ◽  
Nitric Oxide Release

Supramolecular poly(acrylic acid)/F127 hydrogel with hydration-controlled nitric oxide release for enhancing wound healing

2018 ◽  
Vol 74 ◽  
pp. 312-325 ◽  
Author(s):  
Mathilde Champeau ◽  
Valéria Póvoa ◽  
Lucas Militão ◽  
Flávia M. Cabrini ◽  
Guilherme F. Picheth ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Wound Healing ◽  
Acrylic Acid ◽  
Nitric Oxide Release ◽  
Poly Acrylic Acid

scholarly journals Nitric Oxide Release from Antimicrobial Peptide Hydrogels for Wound Healing

Biomolecules ◽  
2018 ◽  
Vol 9 (1) ◽  
pp. 4 ◽  
Author(s):  
Joana Durão ◽  
Nuno Vale ◽  
Salomé Gomes ◽  
Paula Gomes ◽  
Cristina C. Barrias ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Wound Healing ◽  
Antimicrobial Peptide ◽  
Chronic Wounds ◽  
Dermal Fibroblasts ◽  
Initial Increase ◽  
No Donor ◽  
Collagen Production ◽  
Nitric Oxide Release ◽  
Lysine Residues

Nitric oxide (NO) is an endogenously produced molecule that has been implicated in several wound healing mechanisms. Its topical delivery may improve healing in acute or chronic wounds. In this study an antimicrobial peptide was synthesized which self-assembled upon a pH shift, forming a hydrogel. The peptide was chemically functionalized to incorporate a NO-donor moiety on lysine residues. The extent of the reaction was measured by ninhydrin assay and the NO release rate was quantified via the Griess reaction method. The resulting compound was evaluated for its antimicrobial activity against Escherichia coli, and its effect on collagen production by fibroblasts was assessed. Time-kill curves point to an initial increase in bactericidal activity of the functionalized peptide, and collagen production by human dermal fibroblasts when incubated with the NO-functionalized peptide showed a dose-dependent increase in the presence of the NO donor within a range of 0–20 μM.

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