Tanshinone IIA Delivery Silk Fibroin Scaffolds Significantly Enhance Articular Cartilage Defect Repairing via Promoting Cartilage Regeneration

2020 ◽  
Vol 12 (19) ◽  
pp. 21470-21480
Author(s):  
Wei Chen ◽  
Yong Xu ◽  
Hao Li ◽  
Yao Dai ◽  
Guangdong Zhou ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Silk Fibroin ◽  
Cartilage Defect ◽  
Cartilage Regeneration ◽  
Tanshinone Iia ◽  
Articular Cartilage Defect

Combined Effects of Bone Marrow-Derived Mesenchymal Stem Cells and PLGA-PEG-PLGA Scaffolds on Repair of Articular Cartilage Defect

2013 ◽  
Vol 815 ◽  
pp. 345-349 ◽  
Author(s):  
Ching Wen Hsu ◽  
Ping Liu ◽  
Song Song Zhu ◽  
Feng Deng ◽  
Bi Zhang
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Articular Cartilage ◽  
Growth Factor ◽  
Cartilage Defect ◽  
Cartilage Regeneration ◽  
Tissue Growth ◽  
Cartilage Defects

Here we reported a combined technique for articular cartilage repair, consisting of bone arrow mesenchymal stem cells (BMMSCs) and poly (dl-lactide-co-glycolide-b-ethylene glycol-b-dl-lactide-co-glycolide) (PLGA-PEG-PLGA) triblock copolymers carried with tissue growth factor (TGF-belat1). In the present study, BMMSCs seeded on PLGA-PEG-PLGA with were incubated in vitro, carried or not TGF-belta1, Then the effects of the composite on repair of cartilage defect were evaluated in rabbit knee joints in vivo. Full-thickness cartilage defects (diameter: 5 mm; depth: 3 mm) in the patellar groove were either left empty (n=18), implanted with BMMSCs/PLGA (n=18), TGF-belta1 modified BMMSCs/PLGA-PEG-PLGA. The defect area was examined grossly, histologically at 6, 24 weeks postoperatively. After implantation, the BMMSCs /PLGA-PEG-PLGA with TGF-belta1 group showed successful hyaline-like cartilage regeneration similar to normal cartilage, which was superior to the other groups using gross examination, qualitative and quantitative histology. These findings suggested that a combination of BMMSCs/PLGA-PEG-PLGA carried with tissue growth factor (TGF-belat1) may be an alternative treatment for large osteochondral defects in high loading sites.

scholarly journals Hepatocyte growth factor facilitates cartilage repair: Full thickness articular cartilage defect studied in rabbit knees

1997 ◽  
Vol 68 (5) ◽  
pp. 474-480 ◽  
Author(s):  
Shigeyuki Wakitani ◽  
Kazuhiko Imoto ◽  
Tomoatsu Kimura ◽  
Takahiro Ochi ◽  
Kunio Matsumoto ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Cartilage Repair ◽  
Cartilage Defect ◽  
Full Thickness ◽  
Articular Cartilage Defect ◽  
Hepatocyte Growth

scholarly journals Advanced Strategies for Articular Cartilage Defect Repair

Materials ◽  
2013 ◽  
Vol 6 (2) ◽  
pp. 637-668 ◽  
Author(s):  
Amos Matsiko ◽  
Tanya Levingstone ◽  
Fergal O'Brien
Keyword(s):  
Articular Cartilage ◽  
Cartilage Defect ◽  
Articular Cartilage Defect ◽  
Cartilage Defect Repair ◽  
Defect Repair

scholarly journals Chitosan composite scaffolds for articular cartilage defect repair: a review

RSC Advances ◽  
2018 ◽  
Vol 8 (7) ◽  
pp. 3736-3749 ◽  
Author(s):  
Huijun Li ◽  
Cheng Hu ◽  
Huijun Yu ◽  
Chuanzhong Chen
Keyword(s):  
Articular Cartilage ◽  
Cartilage Defect ◽  
Composite Scaffolds ◽  
Articular Cartilage Defect ◽  
Cartilage Defect Repair ◽  
Defect Repair ◽  
Chitosan Composite

Properties of chitosan/polymer and chitosan/bioceramic composite scaffolds for articular cartilage defect repair are reviewed.

Repair of Articular Cartilage Defect with Cell-Loaded Nano-HA/PLGA Composites

2007 ◽  
pp. 1185-1188
Author(s):  
H. Lu ◽  
S.M. Zhang ◽  
L. Cheng ◽  
P.P. Chen ◽  
W. Zhou ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Cartilage Defect ◽  
Articular Cartilage Defect
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