scholarly journals Engineered pH-Responsive Mesoporous Carbon Nanoparticles for Drug Delivery

2020 ◽  
Vol 12 (13) ◽  
pp. 14946-14957 ◽  
Author(s):  
Miguel Gisbert-Garzarán ◽  
Julia C. Berkmann ◽  
Dimitra Giasafaki ◽  
Daniel Lozano ◽  
Konstantinos Spyrou ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Carbon Nanoparticles ◽  
Mesoporous Carbon ◽  
Ph Responsive

scholarly journals pH-Responsive Mesoporous Silica and Carbon Nanoparticles for Drug Delivery

2017 ◽  
Vol 4 (4) ◽  
pp. 3 ◽  
Author(s):  
Miguel Gisbert-Garzarán ◽  
Miguel Manzano ◽  
María Vallet-Regí
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Carbon Nanoparticles ◽  
Ph Responsive

A carbon based drug delivery system derived from a one-dimensional coordination polymer, doxorubicin loading and redox-responsive release

2017 ◽  
Vol 4 (8) ◽  
pp. 1344-1351 ◽  
Author(s):  
Yuan Jia ◽  
Xinxin Xu ◽  
Jinzhao Ou ◽  
Xiaoxia Liu ◽  
Fa-nian Shi
Keyword(s):  
Drug Delivery ◽  
Coordination Polymer ◽  
Drug Delivery System ◽  
Delivery System ◽  
Carbon Nanoparticles ◽  
Mesoporous Carbon ◽  
One Dimensional ◽  
Redox Responsive ◽  
Carbon Based

A redox-responsive drug delivery system has been fabricated through the modification of –S–S– bonds on coordination polymer derived mesoporous carbon nanoparticles with Ag as a “gatekeeper”.

Nanostructures for pH-sensitive Drug Delivery and Magnetic Resonance Contrast Enhancement Systems

2018 ◽  
Vol 25 (25) ◽  
pp. 3036-3057 ◽  
Author(s):  
Xiao Sun ◽  
Guilong Zhang ◽  
Zhengyan Wu
Keyword(s):  
Drug Delivery ◽  
Magnetic Resonance ◽  
Drug Release ◽  
Contrast Enhancement ◽  
General Strategy ◽  
Ph Responsive ◽  
Physicochemical Changes ◽  
Magnetic Resonance Contrast ◽  
Resonance Contrast ◽  
Magnetic Resonance Contrast Enhancement

According to the differences of microenvironments between tumors and healthy tissues, if the anticancer drugs or magnetic resonance contrast agents (MRCAs) can be controlled to precisely match physiological needs at targeted tumor sites, it is expected to acquire better therapeutic efficacy and more accurate diagnosis. Over the decade, stimuli-responsive nanomaterials have been a research hotspot for cancer treatment and diagnosis because they show many excellent functions, such as in vivo imaging, combined targeting drug delivery and systemic controlled release, extended circulation time, etc. Among the various stimuli nanosystems, pH-stimuli mode is regarded as the most general strategy because of solid tumors acidosis. When exposed to weakly acidic tumor microenvironment, pH-responsive nanoplatforms can generate physicochemical changes for their structure and surface characteristics, causing drug release or contrast enhancement. In this review, we focused on the designs of various pH-responsive nanoplatforms and discussed the mechanisms of controlled drug release or switch on-off in MRCAs. This review also discussed the efficacy of cellular internalization for these nanoplatforms via endocytosis of acidic tumor cell. Meanwhile, nanoplatforms response to acidic intracellular pH (such as endosome, lysosome) are discussed, along with approaches for improving drug release performance and magnetic resonance contrast enhancement. A greater understanding of these pH-responsive nanoplatforms will help design more efficient nanomedicine to address the challenges encountered in conventional diagnosis and chemotherapy.

Strategies for Conjugation of Biomolecules to Nanoparticles as Tumor Targeting Agents

2019 ◽  
Vol 25 (37) ◽  
pp. 3917-3926
Author(s):  
Sajjad Molavipordanjani ◽  
Seyed Jalal Hosseinimehr
Keyword(s):  
Drug Delivery ◽  
Iron Oxide ◽  
Medical Imaging ◽  
Cancer Diagnosis ◽  
Carbon Nanoparticles ◽  
Tumor Targeting ◽  
Polymeric Nanoparticles ◽  
Inorganic Nanoparticles ◽  
Active Targeting ◽  
Cancer Diagnosis And Therapy

Combination of nanotechnology, biochemistry, chemistry and biotechnology provides the opportunity to design unique nanoparticles for tumor targeting, drug delivery, medical imaging and biosensing. Nanoparticles conjugated with biomolecules such as antibodies, peptides, vitamins and aptamer can resolve current challenges including low accumulation, internalization and retention at the target site in cancer diagnosis and therapy through active targeting. In this review, we focus on different strategies for conjugation of biomolecules to nanoparticles such as inorganic nanoparticles (iron oxide, gold, silica and carbon nanoparticles), liposomes, lipid and polymeric nanoparticles and their application in tumor targeting.

Synthesis of pH-responsive triazine skeleton nano-polymer composite containing AIE group for drug delivery

2021 ◽  
Author(s):  
Yifan Zhang ◽  
Xueying Peng ◽  
Xinbo Jing ◽  
Lin Cui ◽  
Shengchao Yang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Polymer Composite ◽  
Ph Responsive
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