scholarly journals A Luminescent Mg-Metal–Organic Framework for Sustained Release of 5-Fluorouracil: Appropriate Host–Guest Interaction and Satisfied Acid–Base Resistance

2020 ◽  
Vol 12 (13) ◽  
pp. 14914-14923 ◽  
Author(s):  
Zengchi Hu ◽  
Chengfang Qiao ◽  
Zhengqiang Xia ◽  
Feng Li ◽  
Jing Han ◽  
...  
Keyword(s):  
Sustained Release ◽  
Metal Organic Framework ◽  
Acid Base ◽  
Base Resistance ◽  
Metal Organic ◽  
Organic Framework

scholarly journals Investigation of Metal-Organic Framework-5 (MOF-5) as an Antitumor Drug Oridonin Sustained Release Carrier

Molecules ◽  
2019 ◽  
Vol 24 (18) ◽  
pp. 3369 ◽  
Author(s):  
Gongsen Chen ◽  
Juyuan Luo ◽  
Mengru Cai ◽  
Liuying Qin ◽  
Yibo Wang ◽  
...  
Keyword(s):  
Sustained Release ◽  
Anticancer Activity ◽  
Hepg2 Cells ◽  
Metal Organic Framework ◽  
Drug Carrier ◽  
Drug Loading ◽  
Addition Method ◽  
Direct Addition ◽  
Metal Organic ◽  
Organic Framework

Oridonin (ORI) is a natural active ingredient with strong anticancer activity. But its clinical use is restricted due to its poor water solubility, short half-life, and low bioavailability. The aim of this study is to utilize the metal organic framework material MOF-5 to load ORI in order to improve its release characteristics and bioavailability. Herein, MOF-5 was synthesized by the solvothermal method and direct addition method, and characterized by Scanning Electron Microscopy (SEM), X-Ray Diffraction (XRD), Fourier Transform Infrared Spectrometer (FTIR), Thermogravimetric Analysis (TG), Brunauer–Emmett–Teller (BET), and Dynamic Light Scattering (DLS), respectively. MOF-5 prepared by the optimal synthesis method was selected for drug-loading and in vitro release experiments. HepG2 cells were model cells. MTT assay, 4′,6-diamidino-2-phenylindole (DAPI) staining and Annexin V/PI assay were used to detect the biological safety of blank carriers and the anticancer activity of drug-loaded materials. The results showed that nano-MOF-5 prepared by the direct addition method had complete structure, uniform size and good biocompatibility, and was suitable as an ORI carrier. The drug loading of ORI@MOF-5 was 52.86% ± 0.59%. The sustained release effect was reliable, and the cumulative release rate was about 87% in 60 h. ORI@MOF-5 had significant cytotoxicity (IC50:22.99 μg/mL) and apoptosis effect on HepG2 cells. ORI@MOF-5 is hopeful to become a new anticancer sustained release preparation. MOF-5 has significant potential as a drug carrier material.

Application of an amino-functionalised metal–organic framework: an approach to a one-pot acid–base reaction

RSC Advances ◽  
2013 ◽  
Vol 3 (44) ◽  
pp. 21582 ◽  
Author(s):  
Takashi Toyao ◽  
Mika Fujiwaki ◽  
Yu Horiuchi ◽  
Masaya Matsuoka
Keyword(s):  
Metal Organic Framework ◽  
Acid Base ◽  
One Pot ◽  
Metal Organic ◽  
Organic Framework

Efficient separation of C2H2from C2H2/CO2mixtures in an acid–base resistant metal–organic framework

2018 ◽  
Vol 54 (38) ◽  
pp. 4846-4849 ◽  
Author(s):  
Ling Zhang ◽  
Ke Jiang ◽  
Libo Li ◽  
Yu-Pei Xia ◽  
Tong-Liang Hu ◽  
...  
Keyword(s):  
Metal Organic Framework ◽  
Acid Base ◽  
Efficient Separation ◽  
Metal Organic ◽  
Organic Framework

An acid–base resistant metal–organic framework,ZJU-196, for excellent C2H2/CO2separation has been successfully synthesised.

scholarly journals Carbon dioxide capture and conversion by an acid-base resistant metal-organic framework

2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Linfeng Liang ◽  
Caiping Liu ◽  
Feilong Jiang ◽  
Qihui Chen ◽  
Linjie Zhang ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Carbon Dioxide Capture ◽  
Metal Organic Framework ◽  
Acid Base ◽  
Metal Organic ◽  
Organic Framework

A computational study of the effect of the metal organic framework environment on the release of chemically stored nitric oxide

2015 ◽  
Vol 17 (36) ◽  
pp. 23403-23412 ◽  
Author(s):  
Tanping Li ◽  
Kiara Taylor-Edinbyrd ◽  
Revati Kumar
Keyword(s):  
Nitric Oxide ◽  
Sustained Release ◽  
Computational Study ◽  
Metal Organic Framework ◽  
Metal Organic ◽  
Organic Framework

Computational investigations into the effect of a copper based metal organic framework on the sustained release of NO from S-nitrosothiols.

scholarly journals An amino-modified Zr-terephthalate metal–organic framework as an acid–base catalyst for cross-aldol condensation

2011 ◽  
Vol 47 (5) ◽  
pp. 1521-1523 ◽  
Author(s):  
Frederik Vermoortele ◽  
Rob Ameloot ◽  
Alexandre Vimont ◽  
Christian Serre ◽  
Dirk De Vos
Keyword(s):  
Aldol Condensation ◽  
Metal Organic Framework ◽  
Base Catalyst ◽  
Acid Base ◽  
Metal Organic ◽  
Organic Framework
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