scholarly journals Ultrafast Particle Size Reduction of Fe73.9Si15.5Cu1Nb3B6.6 by High-Energy Milling: Nb2O5 as a Marker of Permeability Enhancement and Magnetic Hardening

2020 ◽  
Vol 2 (5) ◽  
pp. 1484-1496 ◽  
Author(s):  
Jesús López-Sánchez ◽  
Elena Navarro ◽  
Aída Serrano ◽  
Cecilia Granados-Miralles ◽  
Adolfo del Campo ◽  
...  
Keyword(s):  
Particle Size ◽  
High Energy ◽  
Size Reduction ◽  
Particle Size Reduction ◽  
High Energy Milling ◽  
Permeability Enhancement ◽  
Magnetic Hardening

Microstructural effects of high-energy grinding on poorly soluble drugs: the case study of efavirenz

2017 ◽  
Vol 32 (S1) ◽  
pp. S135-S140 ◽  
Author(s):  
Elisa Cappelletto ◽  
Luca Rebuffi ◽  
Alberto Flor ◽  
Paolo Scardi
Keyword(s):  
Particle Size ◽  
Grain Size ◽  
Mechanical Activation ◽  
Morphological Changes ◽  
Domain Size ◽  
High Energy ◽  
Water Soluble ◽  
Size Reduction ◽  
Dissolution Behavior ◽  
Particle Size Reduction

In this work, a poorly water-soluble drug (efavirenz) was mechanically activated by ball-milling. The effect of the mechanical activation on the dissolution behavior was investigated considering changes in the particle size and morphology. The powder diffraction was used to follow the comminution process, verifying phase compositions, and crystalline domain size. The interplay between domain and grain size was studied in relation to the solubility rate, through specific dissolution tests. Finally, the morphological characterization has allowed to complete the physical–chemical characterization of the milled powders. This study demonstrated that the mechanical activation of the drug leads the particle size reduction and, with a long milling time, morphological changes. The grain size reduction is not always sufficient to increase the solubility: morphology and agglomeration grade play an important role in the dissolution process.

scholarly journals Structure and Magnetic Properties Of Fe/Si Nanoparticles Prepared by High Energy Milling Process

2021 ◽  
Vol 11 (2) ◽  
pp. 239
Author(s):  
Muhammad Rifai ◽  
Yunasfi Yunasfi ◽  
Engkir Sukirman ◽  
Yosef Sarwanto ◽  
Mujamilah Mujamilah
Keyword(s):  
Phase Transition ◽  
Particle Size ◽  
Magnetic Properties ◽  
Iron Oxides ◽  
High Energy ◽  
Milling Process ◽  
Particle Size Reduction ◽  
High Energy Milling ◽  
Si Nanoparticle ◽  
Si Nanoparticles

The structure and magnetic properties of Fe/Si nanoparticle prepared by high energy milling process have been examined, focusing on the phase transition. Fe/Si nanoparticles were processed by high energy milling (HEM) for 10 hours to 50 hours with a weight per cent ratio of 9:1. Based on the X-ray diffraction (XRD) pattern, transmission electron microscope (TEM) observations, and vibrating sample magnetometer (VSM) analysis, the phase transition induced by HEM, were evidenced. The effect of structural state and the particle size on the magnetic properties such as magnetization was also studied. It was found that iron and iron oxides (-Fe2O3/ Fe3O4) phase were exhibited on all milled samples. The magnetization value of Fe/Si nanoparticles increased up to 20 hours with 142 emu/gr saturated magnetization and then decreased linearly with increasing milling time. Referring to the XRD result, this decline was initially caused by the iron oxide formation and magnetic interaction between iron and iron oxides nanoparticles. The phase and magnetic properties value changes related to the interaction mechanism between Fe atoms caused by interstitial occupied of Si atoms, particle size reduction, and oxidation process.

scholarly journals Influence of the shaker mill in the properties of ZnO processed by high energy milling

2021 ◽  
Vol 10 (12) ◽  
pp. e476101220855
Author(s):  
Ana Gabriela Storion ◽  
Eliria Maria de Jesus Agnolon Pallone ◽  
Tania Regina Giraldi ◽  
Sylma Carvalho Maestrelli
Keyword(s):  
Particle Size ◽  
High Energy ◽  
Hexagonal Structure ◽  
Size Reduction ◽  
Particle Size Reduction ◽  
Short Processing Time ◽  
Mean Size ◽  
C Value ◽  
Energy Ball ◽  
Zno Powder

This work evaluates how the High Energy Ball Milling (HEBM) in a shaker mill influences the optical, physical, and microstructural properties of ZnO. The procedure also combines Fe inclusion from the grinding medium with particle size reduction. ZnO powder was milled by 1, 2, 3, 4, and 5 h, which resulted in a particle size reduction to the nanometric scale with a mean size of around 50 nm and a crystallite size reduction by three times when processed from 4 h. Milling has proven to be an efficient process for obtaining nanoparticles with an incredibly short processing time and changed the morphology of the particles from random to spherical shapes. Results also indicate the processing progressively expanded the ZnO hexagonal structure due to the imposed strain and Fe inclusion, which can help to decrease the bandgap and slow down the recombination rate of the electron-hole pairs, improving the photocatalysis activity. The optical results showed no additional band appeared due to milling processes and diminished the bandgap from 3.37 to 3.21 eV. Milling also led to an increase in the c value from 5.2076 to 5.2112 Å, which is one of the most important factors for improved antibacterial activity. HEBM has proved to be a suitable process for obtaining ZnO nanoparticles with properties useful for various applications.

Methods for particle size reduction of liposomal amphotericin B

2018 ◽  
Vol 60 (1) ◽  
pp. 42-45
Author(s):  
Tuan Quang Nguyen ◽  
Van Lam Nguyen ◽  
Thai Son Nguyen ◽  
Thi Minh Hue Pham ◽  
◽  
...  
Keyword(s):  
Particle Size ◽  
Amphotericin B ◽  
Liposomal Amphotericin ◽  
Size Reduction ◽  
Liposomal Amphotericin B ◽  
Particle Size Reduction

scholarly journals Laser Superficial Fusion of Gold Nanoparticles with PEEK Polymer for Cardiovascular Application

Materials ◽  
2021 ◽  
Vol 14 (4) ◽  
pp. 971
Author(s):  
Oktawian Bialas ◽  
Mateusz Lis ◽  
Anna Woźniak ◽  
Marcin Adamiak
Keyword(s):  
Particle Size ◽  
Laser Beam ◽  
Gold Particle ◽  
Laser Power ◽  
Biomedical Application ◽  
Parameters Optimization ◽  
Size Reduction ◽  
Particle Size Reduction ◽  
Nano Gold ◽  
Gold Particle Size

This paper analyses the possibility of obtaining surface-infused nano gold particles with the polyether ether ketone (PEEK) using picosecond laser treatment. To fuse particles into polymer, the raw surface of PEEK was sputtered with 99.99% Au and micromachined by an A-355 laser device for gold particle size reduction. Biomimetic pattern and parameters optimization were key properties of the design for biomedical application. The structures were investigated by employing surface topography in the presence of micron and sub-micron features. The energy of the laser beam stating the presence of polymer bond thermalisation with remelting due to high temperature was also taken into the account. The process was suited to avoid intensive surface modification that could compromise the mechanical properties of fragile cardiovascular devices. The initial material analysis was conducted by power–depth dependence using confocal microscopy. The evaluation of gold particle size reduction was performed with scanning electron microscopy (SEM), secondary electron (SE) and quadrant backscatter electron detector (QBSD) and energy dispersive spectroscopy (EDS) analysis. The visibility of the constituted coating was checked by a commercial grade X-ray that is commonly used in hospitals. Attempts to reduce deposited gold coating to the size of Au nanoparticles (Au NPs) and to fuse them into the groove using a laser beam have been successfully completed. The relationship between the laser power and the characteristics of the particles remaining in the laser irradiation area has been established. A significant increase in quantity was achieved using laser power with a minimum power of 15 mW. The obtained results allowed for the continuation of the pilot study for augmented research and material properties analysis.

scholarly journals Characterization of Astaxanthin Nanoemulsions Produced by Intense Fluid Shear through a Self-Throttling Nanometer Range Annular Orifice Valve-Based High-Pressure Homogenizer

Molecules ◽  
2021 ◽  
Vol 26 (10) ◽  
pp. 2856
Author(s):  
Gary B. Smejkal ◽  
Edmund Y. Ting ◽  
Karthik Nambi Arul Nambi ◽  
Richard T. Schumacher ◽  
Alexander V. Lazarev
Keyword(s):  
Particle Size ◽  
Size Reduction ◽  
Hydrodynamic Diameter ◽  
Fluid Shear ◽  
Particle Size Reduction ◽  
Annular Gap ◽  
Oil In Water ◽  
High Pressure Homogenizer ◽  
Pass Through

Stable, oil-in-water nanoemulsions containing astaxanthin (AsX) were produced by intense fluid shear forces resulting from pumping a coarse reagent emulsion through a self-throttling annular gap valve at 300 MPa. Compared to crude emulsions prepared by conventional homogenization, a size reduction of over two orders of magnitude was observed for AsX-encapsulated oil droplets following just one pass through the annular valve. In krill oil formulations, the mean hydrodynamic diameter of lipid particles was reduced to 60 nm after only two passes through the valve and reached a minimal size of 24 nm after eight passes. Repeated processing of samples through the valve progressively decreased lipid particle size, with an inflection in the rate of particle size reduction generally observed after 2–4 passes. Krill- and argan oil-based nanoemulsions were produced using an Ultra Shear Technology™ (UST™) approach and characterized in terms of their small particle size, low polydispersity, and stability.

scholarly journals Sonocrystallization—Case Studies of Salicylamide Particle Size Reduction and Isoniazid Derivative Synthesis and Crystallization

Crystals ◽  
2018 ◽  
Vol 8 (6) ◽  
pp. 249 ◽  
Author(s):  
Zhen-Yu Yang ◽  
Shih-Kuo Yen ◽  
Wei-Syun Hu ◽  
Yu-Zhe Huang ◽  
Tsung-Mao Yang ◽  
...  
Keyword(s):  
Particle Size ◽  
Case Studies ◽  
Size Reduction ◽  
Particle Size Reduction

Substrate particle size reduction by Bacillus coagulans in solid-state fermentation

1996 ◽  
Vol 18 (2) ◽  
pp. 121-125 ◽  
Author(s):  
M.P. Nandakumar ◽  
M.S. Thakur ◽  
K.S.M.S. Raghavarao ◽  
N.P. Ghildyal
Keyword(s):  
Particle Size ◽  
Solid State ◽  
Solid State Fermentation ◽  
Bacillus Coagulans ◽  
Size Reduction ◽  
Particle Size Reduction ◽  
Substrate Particle
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