Chemical Stability-Sensitive Osteoconductive Performance of Octacalcium Phosphate Bone Substitute in an Ovariectomized Rat Tibia Defect

2020 ◽  
Vol 3 (3) ◽  
pp. 1444-1458
Author(s):  
Kazuyoshi Baba ◽  
Yukari Shiwaku ◽  
Ryo Hamai ◽  
Yu Mori ◽  
Takahisa Anada ◽  
...  
Keyword(s):  
Chemical Stability ◽  
Bone Substitute ◽  
Octacalcium Phosphate ◽  
Ovariectomized Rat ◽  
Rat Tibia ◽  
Tibia Defect

scholarly journals Evaluation of injectable silica-embedded nanohydroxyapatite bone substitute in a rat tibia defect model

2011 ◽  
pp. 1543 ◽  
Author(s):  
Weiguo Xu ◽  
Cornelia Ganz ◽  
Ulf Weber ◽  
Martin Adam ◽  
Daniel Wolter ◽  
...  
Keyword(s):  
Bone Substitute ◽  
Defect Model ◽  
Rat Tibia ◽  
Tibia Defect

Immune cell response and subsequent bone formation induced by implantation of octacalcium phosphate in a rat tibia defect

RSC Advances ◽  
2016 ◽  
Vol 6 (62) ◽  
pp. 57475-57484 ◽  
Author(s):  
Bunichi Hirayama ◽  
Takahisa Anada ◽  
Yukari Shiwaku ◽  
Naohisa Miyatake ◽  
Kaori Tsuchiya ◽  
...  
Keyword(s):  
Immune Response ◽  
Bone Formation ◽  
Cell Response ◽  
Immune Cell ◽  
Octacalcium Phosphate ◽  
Bone Defects ◽  
Rat Tibia ◽  
Immune Cell Response ◽  
Tibia Defect

The present study was designed to investigate how octacalcium phosphate (OCP) induces an immune response and whether the response is involved in the biodegradation and subsequent bone formation by OCP implantation in bone defects.

Topical Application of Slow-Release Simvastatin as a Bone Substitute in Bone Defects in the Rat Tibia: A Pilot Study

2014 ◽  
Vol 29 (2) ◽  
pp. e241-e246 ◽  
Author(s):  
Heli Rushinek ◽  
Michael Alterman ◽  
Amir Laviv ◽  
Ervin I. Weiss ◽  
Michael Friedman ◽  
...  
Keyword(s):  
Pilot Study ◽  
Topical Application ◽  
Bone Substitute ◽  
Slow Release ◽  
Bone Defects ◽  
Rat Tibia

Bone substitute as an on-lay graft on rat tibia

2010 ◽  
Vol 21 (4) ◽  
pp. 424-429 ◽  
Author(s):  
A. Truedsson ◽  
J.-S. Wang ◽  
P. Lindberg ◽  
M. Gordh ◽  
B. Sunzel ◽  
...  
Keyword(s):  
Bone Substitute ◽  
Rat Tibia

Effects of risedronate on trabecular microstructure and biomechanical properties in ovariectomized rat tibia

2005 ◽  
Vol 16 (9) ◽  
pp. 1042-1048 ◽  
Author(s):  
Masako Ito ◽  
Akifumi Nishida ◽  
Kiyoshi Aoyagi ◽  
Masataka Uetani ◽  
Kuniaki Hayashi ◽  
...  
Keyword(s):  
Biomechanical Properties ◽  
Ovariectomized Rat ◽  
Trabecular Microstructure ◽  
Rat Tibia

scholarly journals Bone Tissue Response to Different Grown Crystal Batches of Octacalcium Phosphate in Rat Long Bone Intramedullary Canal Area

2021 ◽  
Vol 22 (18) ◽  
pp. 9770
Author(s):  
Yukari Shiwaku ◽  
Ryo Hamai ◽  
Shinichi Sato ◽  
Susumu Sakai ◽  
Kaori Tsuchiya ◽  
...  
Keyword(s):  
Octacalcium Phosphate ◽  
Tissue Response ◽  
Ion Concentration ◽  
Long Bone ◽  
Dissolution Behavior ◽  
Control Group ◽  
Tubular Bone ◽  
Biological Responses ◽  
Intramedullary Canal ◽  
Rat Tibia

The microstructure of biomaterials influences the cellular and biological responses in the bone. Octacalcium phosphate (OCP) exhibits higher biodegradability and osteoconductivity than hydroxyapatite (HA) during the conversion process from OCP to HA. However, the effect of the microstructure of OCP crystals on long tubular bones has not been clarified. In this study, two types of OCPs with different microstructures, fine-OCP (F-OCP) and coarse-OCP (C-OCP), were implanted in rat tibia for 4 weeks. F-OCP promoted cortical bone regeneration compared with C-OCP. The osteoclasts appearance was significantly higher in the C-OCP group than in the control group (defect only) at 1-week post-implantation. To investigate whether the solubility equilibrium depends on the different particle sizes of OCPs, Nano-OCP, which consisted of nanometer-sized OCPs, was prepared. The degree of supersaturation (DS) tended to decrease modestly in the order of C-OCP, F-OCP, and Nano-OCP with respect to HA and OCP in Tris-HCl buffer. F-OCP showed a higher phosphate ion concentration and lower calcium ion concentration after immersion in the buffer than C-OCP. The crystal structures of both OCPs tended to be converted to HA by rat abdominal implantation. These results suggest that differences in the microstructure of OCPs may affect osteoclastogenesis and result in osteoconductivity of this material in long tubular bone by altering dissolution behavior.

scholarly journals STIMULATORY CAPACITY OF AN OCTACALCIUM PHOSPHATE/GELATIN COMPOSITE ON BONE REGENERATION IN A RABBIT TIBIA DEFECT MODEL

2012 ◽  
Vol 26 (0) ◽  
pp. 53-58 ◽  
Author(s):  
Kentaro Suzuki ◽  
Yoshitomo Honda ◽  
Takahisa Anada ◽  
Takuto Handa ◽  
Naohisa Miyatake ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Octacalcium Phosphate ◽  
Defect Model ◽  
Rabbit Tibia ◽  
Stimulatory Capacity ◽  
Tibia Defect

Bone Grafting Putty – Animal Experiments and Clinical Applications

2012 ◽  
Vol 529-530 ◽  
pp. 285-290 ◽  
Author(s):  
Thomas Gerber ◽  
Cornelia Ganz ◽  
W. Xu ◽  
F. Maier ◽  
B. Frerich ◽  
...  
Keyword(s):  
Bone Graft ◽  
Animal Experiments ◽  
Bone Graft Substitute ◽  
Clinical Applications ◽  
Socket Preservation ◽  
Dental Application ◽  
New Material ◽  
Rat Tibia ◽  
High Level ◽  
Tibia Defect

The aim of the described study was to generate and evaluate a putty-like bone graft substitute ready to use for dental and orthopedic surgery. According to the asking of clinicians the new material should avoid the necessity of mixing blood and bone graft during the surgical process. Therefor the granulous material NanoBone® has been combined with a hydrogel based on Polyvinylpyrrolidone (PVP) and tested in standardized rat tibia defect over a period of 12 weeks and evaluated histologically. The results showed no limitations of the granulate characteristics in matrix change and hence a high level of vascularization and bone formation. An example for dental application shows the outcome in the case of socket preservation.

Gene-Activated Bone Substitute Based on Octacalcium Phosphate and Doped with Magnesium Ions

2018 ◽  
Vol 9 (1) ◽  
pp. 70-74 ◽  
Author(s):  
I. Y. Bozo ◽  
R. V. Deev ◽  
M. N. Zhuravlyova ◽  
V. S. Komlev ◽  
V. K. Popov ◽  
...  
Keyword(s):  
Bone Substitute ◽  
Octacalcium Phosphate ◽  
Magnesium Ions
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