Inhibition of Autophagy via Lysosomal Impairment Enhances Cytotoxicity of Fullerenol under Starvation Condition

2020 ◽  
Vol 3 (2) ◽  
pp. 977-985
Author(s):  
Liyun Yang ◽  
Siyu Hua ◽  
Junpeng Fan ◽  
Zhiqiang Zhou ◽  
Guanchao Wang ◽  
...  
Keyword(s):  
Starvation Condition

scholarly journals Environmental Factors Regulate the hlyE Gene Expression in Both S. typhi and E. coli in a Similar Way to Display Haemolytic Activity

2017 ◽  
Vol 42 (1) ◽  
pp. 33-38 ◽  
Author(s):  
Chowdhury Rafiqul Ahsan ◽  
Farah Shamma ◽  
Nazmul Ahsan ◽  
Moutusee Jubaida Islam
Keyword(s):  
Gene Expression ◽  
Transcription Factor ◽  
Environmental Factors ◽  
Enteric Bacteria ◽  
Stress Conditions ◽  
Haemolytic Activity ◽  
Glucose Starvation ◽  
E Coli ◽  
Starvation Condition ◽  
K 12

Haemolysin (HlyE) is an essential virulence factor of Salmonella, Escherichia coli and other enteric bacteria. Although, a substantial degree of haemolytic activity is not seen under normal culture conditions in these organisms, however, the non-haemolytic E. coli K-12 showed significant haemolytic activity under stress conditions. To confirm this phenomenon in other enteric bacteria, in this study, the production of haemolysin in Salmonella enterica serovar Typhi under stress conditions, like oxygen and glucose starvations in vitro was investigated during March-December 2015. For this, S. typhi was cultured under oxygen or glucose starvation condition separately and this organism showed high haemolytic activity. The activity was found to be much higher when both the conditions were applied together. Also, the role of the transcription factor SlyA of S. typhi was investigated on induction of haemolytic activity. When E. coli K-12 was transformed with plasmid containing the gene of SlyA, the recombinant bacteria without any starvation condition, also showed similar haemolytic activity that was exhibited by S. typhi grown under oxygen and glucose starvation conditions. All these findings suggest that both environmental factors like oxygen or glucose starvation and overexpression of the transcription factor SlyA have important role in inducing hlyE gene expression in S. typhi.

Acclimation of unicellular cyanobacteria to macronutrient deficiency: emergence of a complex network of cellular responses

Microbiology ◽  
2005 ◽  
Vol 151 (8) ◽  
pp. 2503-2514 ◽  
Author(s):  
Rakefet Schwarz ◽  
Karl Forchhammer
Keyword(s):  
Nutrient Limitation ◽  
Complex Network ◽  
Nitrogen Limitation ◽  
Molecular Mechanisms ◽  
Photosynthetic Apparatus ◽  
Cellular Responses ◽  
Nitrogen And Phosphorus ◽  
Starvation Condition ◽  
Phosphorus Deprivation ◽  
Micro Organisms

Cyanobacteria are equipped with numerous mechanisms that allow them to survive under conditions of nutrient starvation, some of which are unique to these organisms. This review surveys the molecular mechanisms underlying acclimation responses to nitrogen and phosphorus deprivation, with an emphasis on non-diazotrophic freshwater cyanobacteria. As documented for other micro-organisms, nutrient limitation of cyanobacteria elicits both general and specific responses. The general responses occur under any starvation condition and are the result of the stresses imposed by arrested anabolism. In contrast, the specific responses are acclimation processes that occur as a result of limitation for a particular nutrient; they lead to modification of metabolic and physiological routes to compensate for the restriction. First, the general acclimation processes are discussed, with an emphasis on modifications of the photosynthetic apparatus. The molecular mechanisms underlying specific responses to phosphorus and nitrogen-limitation are then outlined, and finally the cross-talk between pathways modulating specific and general responses is described.

scholarly journals Accumulation of lipid in Dunaliella salina under Nutrient Starvation Condition

2017 ◽  
Vol 5 (2) ◽  
pp. 58-61 ◽  
Author(s):  
Truc Mai ◽  
Phuc Nguyen ◽  
Trung Vo ◽  
Hieu Huynh ◽  
Son Tran ◽  
...  
Keyword(s):  
Dunaliella Salina ◽  
Nutrient Starvation ◽  
Starvation Condition

Film formation properties of screw tightening lubricant PIB under oil starvation condition

2017 ◽  
Vol 2017 (0) ◽  
pp. S1170105
Author(s):  
Takefumi OTSU ◽  
Kyoichi KOMATSU ◽  
Shinji HASHIMURA ◽  
Keiji IMADO
Keyword(s):  
Film Formation ◽  
Starvation Condition

Thermohydrodynamic Modeling of Leading-Edge Groove Bearings under Starvation Condition

2005 ◽  
Vol 48 (3) ◽  
pp. 362-369 ◽  
Author(s):  
M. HE ◽  
P. ALLAIRE ◽  
L. BARRETT ◽  
J. NICHOLAS
Keyword(s):  
Leading Edge ◽  
Starvation Condition

scholarly journals Aplikasi Berbagai Komposisi dan Konsentrasi Pupuk Majemuk untuk Pembentukan Kantong pada Nepenthesx ventrata

2013 ◽  
Vol 1 (1) ◽  
pp. 113
Author(s):  
Romy Agus Saputro ◽  
Sintho Wahyuning Ardie ◽  
. Krisantini
Keyword(s):  
Growth And Development ◽  
Future Research ◽  
Pitcher Plant ◽  
Growing Media ◽  
Under Nutrition ◽  
Starvation Condition ◽  
Number Of Leaves ◽  
Original Habitat ◽  
Slow Growing ◽  
Development Application

<p style="text-align: justify;">Nepenthes is a genus of carnivorous plants in the monotypic family Nepenthaceae. The genus comprises around 130 species, numerous natural and many cultivated hybrids. Plants generally need fertilizer to promote their growth and development. However, in their original habitat Nepenthes forms pitchers under nutrition starvation condition. This study aimed at determining the effect of fertilization on the growth and pitcher formation of Nepenthesx ventrata. Experiment was conducted at Suska Nursery, Caringin, West Java, Indonesia from February until June 2011. Plants were treated with the N: P: K, 60-30-30, 32-10-10 and 10-55-10 and at different concentrations ie, 0.5, 1 and 2 g L-1. Fertilizer was applied weekly to the growing media. Weekly observations were conducted on number of leaves, plant height, time of pitchers initiation, the number of pitchers and pitcher diameter and length. Daily temperature, relative humidity and EC (electrical conductivity) of the growing media were also recorded during the experiment. The results showed that combination of fertilizer with different composition and concentration did not affect Nepenthes growth and development. Application of fertilizer resulted in smaller size pitchers compared to control plants. Future research on Nepenthes should be conducted in a longer period since Nepenthes is a slow growing plants.</p><p>Keywords: Nepenthesx ventrata, fertilizer, pitcher plant</p>

scholarly journals Film formation and shear properties in screw tightening lubricant PIB under oil starvation condition

2017 ◽  
Vol 83 (855) ◽  
pp. 17-00319-17-00319
Author(s):  
Takefumi OTSU ◽  
Kyoichi KOMATSU ◽  
Shinji HASHIMURA ◽  
Keiji IMADO
Keyword(s):  
Film Formation ◽  
Shear Properties ◽  
Starvation Condition

scholarly journals GIT1 contributes to autophagy in osteoclast through disruption of the binding of Beclin1 and Bcl2 under starvation condition

2018 ◽  
Vol 9 (12) ◽  
Author(s):  
Shu-Jie Zhao ◽  
Fan-Qi Kong ◽  
Wei Cai ◽  
Tao Xu ◽  
Zhi-Min Zhou ◽  
...  
Keyword(s):  
Starvation Condition

scholarly journals Organization of the Pre-autophagosomal Structure Responsible for Autophagosome Formation

2008 ◽  
Vol 19 (5) ◽  
pp. 2039-2050 ◽  
Author(s):  
Tomoko Kawamata ◽  
Yoshiaki Kamada ◽  
Yukiko Kabeya ◽  
Takayuki Sekito ◽  
Yoshinori Ohsumi
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Ternary Complex ◽  
Nutrient Depletion ◽  
Autophagosome Formation ◽  
Yeast Saccharomyces Cerevisiae ◽  
Atg Proteins ◽  
Starvation Condition ◽  
Putative Site ◽  
Starvation Conditions

Autophagy induced by nutrient depletion is involved in survival during starvation conditions. In addition to starvation-induced autophagy, the yeast Saccharomyces cerevisiae also has a constitutive autophagy-like system, the Cvt pathway. Among 31 autophagy-related (Atg) proteins, the function of Atg17, Atg29, and Atg31 is required specifically for autophagy. In this study, we investigated the role of autophagy-specific (i.e., non-Cvt) proteins under autophagy-inducing conditions. For this purpose, we used atg11Δ cells in which the Cvt pathway is abrogated. The autophagy-unique proteins are required for the localization of Atg proteins to the pre-autophagosomal structure (PAS), the putative site for autophagosome formation, under starvation condition. It is likely that these Atg proteins function as a ternary complex, because Atg29 and Atg31 bind to Atg17. The Atg1 kinase complex (Atg1–Atg13) is also essential for recruitment of Atg proteins to the PAS. The assembly of Atg proteins to the PAS is observed only under autophagy-inducing conditions, indicating that this structure is specifically involved in autophagosome formation. Our results suggest that Atg1 complex and the autophagy-unique Atg proteins cooperatively organize the PAS in response to starvation signals.

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