Protein and Antibody Delivery into Difficult-to-Transfect Cells by Polymeric Peptide Mimics

2019 ◽  
Vol 3 (1) ◽  
pp. 180-185
Author(s):  
Coralie M. Backlund ◽  
Christopher R. Hango ◽  
Lisa M. Minter ◽  
Gregory N. Tew
Keyword(s):  
Peptide Mimics ◽  
Antibody Delivery ◽  
Polymeric Peptide

scholarly journals Melanin‐Inspired Chromophoric Microparticles Composed of Polymeric Peptide Pigments

2021 ◽  
Author(s):  
Ayala Lampel ◽  
Scott A. McPhee ◽  
Salma Kassem ◽  
Deborah Sementa ◽  
Tlalit Massarano ◽  
...  
Keyword(s):  
Polymeric Peptide

scholarly journals Novel GM1 ganglioside-like peptide mimics prevent the association of cholera toxin to human intestinal epithelial in vitro

Glycobiology ◽  
2016 ◽  
Vol 26 (5) ◽  
pp. 540-540 ◽  
Author(s):  
Robert K Yu ◽  
Seigo Usuki ◽  
Yutaka Itokazu ◽  
Han-Chung Wu
Keyword(s):  
Cholera Toxin ◽  
Gm1 Ganglioside ◽  
Intestinal Epithelial ◽  
Peptide Mimics

Synthesis of dendrimeric N-glyoxylamide peptide mimics

2011 ◽  
Vol 52 (28) ◽  
pp. 3645-3647 ◽  
Author(s):  
Thanh Le ◽  
Wai Ching Cheah ◽  
Kasey Wood ◽  
David St.C. Black ◽  
Mark D. Willcox ◽  
...  
Keyword(s):  
Peptide Mimics

Topical antibody delivery systems produce sustained levels in mucosal tissue and blood

1998 ◽  
Vol 16 (2) ◽  
pp. 163-167 ◽  
Author(s):  
Patricia Y. Kuo ◽  
Jill K. Sherwood ◽  
W. Mark Saltzman
Keyword(s):  
Delivery Systems ◽  
Mucosal Tissue ◽  
Antibody Delivery

Synthesis of silica nanoparticles with controllable surface roughness for therapeutic protein delivery

2015 ◽  
Vol 3 (43) ◽  
pp. 8477-8485 ◽  
Author(s):  
Yuting Niu ◽  
Meihua Yu ◽  
Jun Zhang ◽  
Yannan Yang ◽  
Chun Xu ◽  
...  
Keyword(s):  
Surface Roughness ◽  
Silica Nanoparticles ◽  
Protein Delivery ◽  
Therapeutic Protein ◽  
Antibody Delivery

Silica nanoparticles with controllable surface roughness have been successfully prepared for therapeutic anti-pAkt antibody delivery.

scholarly journals Intracellular Loop 2 Peptides of the Human 5HT1a Receptor are Differential Activators of Gi

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Brian Hall ◽  
Carley Squires ◽  
Keith K. Parker
Keyword(s):  
G Protein ◽  
Pharmacological Intervention ◽  
Intracellular Camp ◽  
Intracellular Loop ◽  
Peptide Mimics ◽  
G Protein Coupling ◽  
5Ht1a Receptor ◽  
Protein Coupling ◽  
Loop Region ◽  
Loop 2

Peptide mimics of intracellular loop 2 (ic2) of the human 5HT1a receptor have been studied with respect to their ability to inhibit agonist binding via interference with receptor-G-protein coupling. These peptides give shallow concentration-effect relationships. Additionally, these peptides have been studied with respect to their ability to trigger the signal transduction system of this Gi-coupled receptor. Two signaling parameters have been quantified: concentration of intracellular cAMP and changes in incorporation into the G protein of a stable analog of GTP. In both cases, peptide mimics near midloop of ic2 actually show agonist activity with efficacy falling off toward both loop termini near TM 3 and TM 4. Previous results have suggested that the loop region near the TM3/ic2 interface is primarily responsible for receptor-G-protein coupling, while the current result emphasizes the mid-ic2 loop region's ability to activate the G protein following initial coupling. A limited number of peptides from the receptor's TM5/ic3 loop vicinity were also studied regarding agonist inhibition and G-protein activation. These peptides provide additional evidence that the human 5HT1a receptor, TM5/ic3 loop region, is involved in both coupling and activation actions. Overall, these results provide further information about potential pharmacological intervention and drug development with respect to the human 5HT1a receptor/G-protein system. Finally, the structural evidence generated here provides testable models pending crystallization and X-ray analysis of the receptor.

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