Quercetin Encapsulated Polymer Nanoparticle for Inhibiting Intracellular Polyglutamine Aggregation

2019 ◽  
Vol 2 (12) ◽  
pp. 5298-5305 ◽  
Author(s):  
Koushik Debnath ◽  
Nihar R. Jana ◽  
Nikhil R. Jana
Keyword(s):  
Polymer Nanoparticle ◽  
Polyglutamine Aggregation

scholarly journals Electrochemiluminescence Enhancement and Particle Structure Stabilization of Polymer Nanoparticle by Doping Anionic Polyelectrolyte and Cationic Polymer Containing Tertiary Amine Groups and Its Highly Sensitive Immunoanalysis

Processes ◽  
2020 ◽  
Vol 8 (9) ◽  
pp. 1054
Author(s):  
Noor Ul Ain ◽  
Tian-Yu Wang ◽  
Xiao-Ning Wu ◽  
Tong-Hong Wei ◽  
Jing-Shuo Zhang ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Tertiary Amine ◽  
Hepatitis B Surface Antigen ◽  
Particle Diameter ◽  
Cationic Polymer ◽  
Suspension Stability ◽  
Good Precision ◽  
Polymer Nanoparticle ◽  
Anionic Polyelectrolyte ◽  
Amine Groups

A doped polymer nanoparticle (dPNP) of electrochemiluminescence (ECL) was prepared via doping the anionic polyelectrolyte polyacrylic acid (PAA) and the cationic polymer poly-ethyleneimine (PEI) into the polymer nanoparticle (PNP), which was self-assembled by Ru(bpy)32+ derivative-grafted PAA (PAA–Ru) with both cations and anions. The good electrical conductivity of the doped polyelectrolyte PAA enhanced the ECL intensity of PNP to 109.1%, and the involvement of a large number of tertiary amine groups of the doped PEI further enhanced that to 127.3%; meanwhile, doping low-molecular-weight PEI into PNP, while simultaneously doping high-molecular-weight PAA, avoided the precipitation of PAA and PEI, due to interaction of the two oppositely charged polymers; and these also made the self-assembly procedure more effective and the nanoparticle structure more stable than PNP and also led to the production of rich residual PAA chains on the surface of dPNP. The storage results showed that the average hydrated particle diameter kept almost constant (197.5–213.1 nm) during 15-day storage and that the nanoparticles have rich surface charge of −11.47 mV (zeta potential), well suspension stability and good dispersity without detectable aggregation in the solution during the storage. Therefore, the nanoparticle is quite suitable for the antibody labeling, immunoassay and the storage. As a result, a high-sensitive ECL immunoassay approach with good precision, accuracy and selectivity was established and an ultra-low detection limit of 0.049 pg mL−1 (S/N = 3) for magnetic bead-based detection of Hepatitis B surface antigen was observed.

Highly antifouling polymer-nanoparticle-nanoparticle/polymer hybrid membranes

2021 ◽  
pp. 152228
Author(s):  
Vahid Vatanpour ◽  
Maryam Jouyandeh ◽  
Seyed Soroush Mousavi Khadem ◽  
Shadi Paziresh ◽  
Ahmad Dehghan ◽  
...  
Keyword(s):  
Hybrid Membranes ◽  
Polymer Nanoparticle ◽  
Polymer Hybrid

scholarly journals Adsorption Behavior of Polymer Chain with Different Topology Structure at the Polymer-Nanoparticle Interface

Polymers ◽  
2018 ◽  
Vol 10 (6) ◽  
pp. 590 ◽  
Author(s):  
Qingliang Song ◽  
Yongyun Ji ◽  
Shiben Li ◽  
Xianghong Wang ◽  
Linli He
Keyword(s):  
Polymer Chain ◽  
Adsorption Behavior ◽  
Topology Structure ◽  
Polymer Nanoparticle
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