Reactive Oxygen Species Synergistic pH/H2O2-Responsive Poly(l-lactic acid)-block-poly(sodium 4-styrenesulfonate)/Citrate-Fe(III)@ZIF-8 Hybrid Nanocomposites for Controlled Drug Release

2019 ◽  
Vol 2 (8) ◽  
pp. 3648-3658 ◽  
Author(s):  
Zhentao Lei ◽  
Yanshan Ju ◽  
Yonghui Lin ◽  
Xiaowen Bai ◽  
Wei Hu ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Lactic Acid ◽  
Drug Release ◽  
Reactive Oxygen ◽  
Controlled Drug Release ◽  
Hybrid Nanocomposites ◽  
Oxygen Species

scholarly journals Photo-Responsive Supramolecular Micelles for Controlled Drug Release and Improved Chemotherapy

2020 ◽  
Vol 22 (1) ◽  
pp. 154
Author(s):  
Fasih Bintang Ilhami ◽  
Kai-Chen Peng ◽  
Yi-Shiuan Chang ◽  
Yihalem Abebe Alemayehu ◽  
Hsieh-Chih Tsai ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Drug Release ◽  
Visible Light ◽  
Cancer Cells ◽  
Laser Irradiation ◽  
Reactive Oxygen ◽  
Controlled Drug Release ◽  
Grand Challenge ◽  
Supramolecular System ◽  
Oxygen Species

Development of stimuli-responsive supramolecular micelles that enable high levels of well-controlled drug release in cancer cells remains a grand challenge. Here, we encapsulated the antitumor drug doxorubicin (DOX) and pro-photosensitizer 5-aminolevulinic acid (5-ALA) within adenine-functionalized supramolecular micelles (A-PPG), in order to achieve effective drug delivery combined with photo-chemotherapy. The resulting DOX/5-ALA-loaded micelles exhibited excellent light and pH-responsive behavior in aqueous solution and high drug-entrapment stability in serum-rich media. A short duration (1–2 min) of laser irradiation with visible light induced the dissociation of the DOX/5-ALA complexes within the micelles, which disrupted micellular stability and resulted in rapid, immediate release of the physically entrapped drug from the micelles. In addition, in vitro assays of cellular reactive oxygen species generation and cellular internalization confirmed the drug-loaded micelles exhibited significantly enhanced cellular uptake after visible light irradiation, and that the light-triggered disassembly of micellar structures rapidly increased the production of reactive oxygen species within the cells. Importantly, flow cytometric analysis demonstrated that laser irradiation of cancer cells incubated with DOX/5-ALA-loaded A-PPG micelles effectively induced apoptotic cell death via endocytosis. Thus, this newly developed supramolecular system may offer a potential route towards improving the efficacy of synergistic chemotherapeutic approaches for cancer.

Endogenous reactive oxygen species burst induced and spatiotemporally controlled multiple drug release by traceable nanoparticles for enhancing antitumor efficacy

2021 ◽  
Author(s):  
Ning Wang ◽  
Chenyu Liu ◽  
Weihe Yao ◽  
Hengjun Zhou ◽  
Simiao Yu ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Drug Release ◽  
Reactive Oxygen ◽  
Combined Effect ◽  
Antitumor Efficacy ◽  
Multiple Drug ◽  
Oxygen Species ◽  
Anticancer Effects ◽  
Endogenous Reactive Oxygen Species ◽  
Reactive Oxygen Species Burst

Reactive oxygen species (ROS) are not only used as a therapeutic reagent in chemodynamic therapy (CDT), to stimulate the release of drugs, they can also be used to achieve a combined effect of CDT and chemotherapy to enhance anticancer effects.

Reactive Oxygen Species-Manipulated Drug Release from a Smart Envelope-Type Mesoporous Titanium Nanovehicle for Tumor Sonodynamic-Chemotherapy

2015 ◽  
Vol 7 (51) ◽  
pp. 28554-28565 ◽  
Author(s):  
Jinjin Shi ◽  
Zhaoyang Chen ◽  
Binghua Wang ◽  
Lei Wang ◽  
Tingting Lu ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Drug Release ◽  
Reactive Oxygen ◽  
Oxygen Species

Synthesis of thermal and oxidation dual responsive polymers for reactive oxygen species (ROS)-triggered drug release

2015 ◽  
Vol 6 (5) ◽  
pp. 738-747 ◽  
Author(s):  
Chunsheng Xiao ◽  
Jianxun Ding ◽  
Lili Ma ◽  
Chenguang Yang ◽  
Xiuli Zhuang ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Drug Release ◽  
Main Chain ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Responsive Polymers ◽  
Dual Responsive ◽  
Responsive Polymer ◽  
Triggered Drug Release

A PEG-based main chain thermo-responsive polymer with oxidation-triggerable thioether groups: synthesis, characterization and its use for ROS-responsive drug release.

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