Spatiotemporal Control Release of pH-Responsive Polymeric Micelles via Photochemically Induced Proton Generation

2019 ◽  
Vol 2 (8) ◽  
pp. 3659-3667
Author(s):  
Tung-Yun Wang ◽  
Ching-Yi Chen
Keyword(s):  
Polymeric Micelles ◽  
Control Release ◽  
Ph Responsive ◽  
Spatiotemporal Control ◽  
Proton Generation

Folate-conjugated and pH-responsive polymeric micelles for target-cell-specific anticancer drug delivery

2017 ◽  
Vol 60 ◽  
pp. 244-255 ◽  
Author(s):  
Jiao Guan ◽  
Zun-Qiang Zhou ◽  
Mao-Hua Chen ◽  
Hui-Yan Li ◽  
Da-Nian Tong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Target Cell ◽  
Polymeric Micelles ◽  
Ph Responsive ◽  
Anticancer Drug Delivery

Synthesis and evaluation of biotin-conjugated pH-responsive polymeric micelles as drug carriers

2012 ◽  
Vol 427 (2) ◽  
pp. 435-442 ◽  
Author(s):  
Ji Hyun Kim ◽  
Yi Li ◽  
Min Sang Kim ◽  
Seong Woo Kang ◽  
Ji Hoon Jeong ◽  
...  
Keyword(s):  
Polymeric Micelles ◽  
Drug Carriers ◽  
Ph Responsive

Polymeric micelles with a pH-responsive structure as intracellular drug carriers

2005 ◽  
Vol 108 (1) ◽  
pp. 140-149 ◽  
Author(s):  
Chau-Hui Wang ◽  
Chun-Hung Wang ◽  
Ging-Ho Hsiue
Keyword(s):  
Polymeric Micelles ◽  
Drug Carriers ◽  
Ph Responsive

Spatiotemporal control over the co-conformational switching in pH-responsive flavylium-based multistate pseudorotaxanes

2015 ◽  
Vol 185 ◽  
pp. 361-379 ◽  
Author(s):  
Ana Marta Diniz ◽  
Nuno Basílio ◽  
Hugo Cruz ◽  
Fernando Pina ◽  
A. Jorge Parola
Keyword(s):  
Molecular Organization ◽  
Present System ◽  
Spectroscopic Techniques ◽  
Ph Responsive ◽  
Conformational Switching ◽  
Ph Values ◽  
Stable Species ◽  
Ph Dependent ◽  
Spatiotemporal Control ◽  
Kinetics Of

A multistate molecular dyad containing flavylium and viologen units was synthesized and the pH dependent thermodynamics of the network completely characterized by a variety of spectroscopic techniques such as NMR, UV-vis and stopped-flow. The flavylium cation is only stable at acidic pH values. Above pH ≈ 5 the hydration of the flavylium leads to the formation of the hemiketal followed by ring-opening tautomerization to give the cis-chalcone. Finally, this last species isomerizes to give the trans-chalcone. For the present system only the flavylium cation and the trans-chalcone species could be detected as being thermodynamically stable. The hemiketal and the cis-chalcone are kinetic intermediates with negligible concentrations at the equilibrium. All stable species of the network were found to form 1 : 1 and 2 : 1 host : guest complexes with cucurbit[7]uril (CB7) with association constants in the ranges 105–108 M−1 and 103–104 M−1, respectively. The 1 : 1 complexes were particularly interesting to devise pH responsive bistable pseudorotaxanes: at basic pH values (≈12) the flavylium cation interconverts into the deprotonated trans-chalcone in a few minutes and under these conditions the CB7 wheel was found to be located around the viologen unit. A decrease in pH to values around 1 regenerates the flavylium cation in seconds and the macrocycle is translocated to the middle of the axle. On the other hand, if the pH is decreased to 6, the deprotonated trans-chalcone is neutralized to give a metastable species that evolves to the thermodynamically stable flavylium cation in ca. 20 hours. By taking advantage of the pH-dependent kinetics of the trans-chalcone/flavylium interconversion, spatiotemporal control of the molecular organization in pseudorotaxane systems can be achieved.

pH-responsive polymeric micelles self-assembled from benzoic-imine-containing alkyl-modified PEGylated chitosan for delivery of amphiphilic drugs

2020 ◽  
Vol 163 ◽  
pp. 1106-1116
Author(s):  
Ching-Wei Hsu ◽  
Ming-Hung Hsieh ◽  
Min-Cong Xiao ◽  
Ya-Hsuan Chou ◽  
Tzu-Hao Wang ◽  
...  
Keyword(s):  
Polymeric Micelles ◽  
Ph Responsive ◽  
Amphiphilic Drugs ◽  
Self Assembled

scholarly journals pH-Responsive Nanoparticles for Cancer Immunotherapy: A Brief Review

Nanomaterials ◽  
2020 ◽  
Vol 10 (8) ◽  
pp. 1613
Author(s):  
Yunfeng Yan ◽  
Hangwei Ding
Keyword(s):  
Cancer Immunotherapy ◽  
Ph Responsive ◽  
Promising Strategy ◽  
Cancer Immunity ◽  
Tumor Tissues ◽  
Wide Range ◽  
Powerful Approach ◽  
Key Steps ◽  
Antigen Presenting ◽  
Spatiotemporal Control

Immunotherapy has recently become a promising strategy for the treatment of a wide range of cancers. However, the broad implementation of cancer immunotherapy suffers from inadequate efficacy and toxic side effects. Integrating pH-responsive nanoparticles into immunotherapy is a powerful approach to tackle these challenges because they are able to target the tumor tissues and organelles of antigen-presenting cells (APCs) which have a characteristic acidic microenvironment. The spatiotemporal control of immunotherapeutic drugs using pH-responsive nanoparticles endows cancer immunotherapy with enhanced antitumor immunity and reduced off-tumor immunity. In this review, we first discuss the cancer-immunity circle and how nanoparticles can modulate the key steps in this circle. Then, we highlight the recent advances in cancer immunotherapy with pH-responsive nanoparticles and discuss the perspective for this emerging area.

pH-Responsive Biomimetic Polymeric Micelles as Lymph Node-Targeting Vaccines for Enhanced Antitumor Immune Responses

2020 ◽  
Vol 21 (7) ◽  
pp. 2818-2828 ◽  
Author(s):  
Xiqin Yang ◽  
Tong Yu ◽  
Yingping Zeng ◽  
Keke Lian ◽  
Xueqing Zhou ◽  
...  
Keyword(s):  
Lymph Node ◽  
Immune Responses ◽  
Polymeric Micelles ◽  
Ph Responsive ◽  
Lymph Node Targeting

The efficiency of tumor-specific pH-responsive peptide-modified polymeric micelles containing paclitaxel

Biomaterials ◽  
2012 ◽  
Vol 33 (8) ◽  
pp. 2508-2520 ◽  
Author(s):  
Bing-Xiang Zhao ◽  
Yang Zhao ◽  
Yue Huang ◽  
Lin-Min Luo ◽  
Ping Song ◽  
...  
Keyword(s):  
Polymeric Micelles ◽  
Ph Responsive

scholarly journals pH-responsive polymeric micelles with core–shell–corona architectures as intracellular anti-cancer drug carriers

2013 ◽  
Vol 14 (4) ◽  
pp. 044402 ◽  
Author(s):  
Bishnu Prasad Bastakoti ◽  
Shih-Hsiang Liao ◽  
Masamichi Inoue ◽  
Shin-Ichi Yusa ◽  
Masataka Imura ◽  
...  
Keyword(s):  
Polymeric Micelles ◽  
Drug Carriers ◽  
Cancer Drug ◽  
Core Shell ◽  
Ph Responsive ◽  
Anti Cancer
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