Hyaluronic Acid-Tacrolimus Bioconjugate: Synthesis, Characterization, and Pharmacokinetic Investigation of an Acid-Responsive Macromolecular Prodrug

2019 ◽  
Vol 2 (11) ◽  
pp. 4728-4736 ◽  
Author(s):  
Divya Dheer ◽  
Rahul Gupta ◽  
Davinder Singh ◽  
Asmita Magotra ◽  
Gurdarshan Singh ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Pharmacokinetic Investigation ◽  
Macromolecular Prodrug

scholarly journals Surface functionalization of superparamagnetic nanoparticles by an acid-liable polysaccharide-based prodrug for combinatorial monitoring and chemotherapy of hepatocellular carcinoma

RSC Advances ◽  
2017 ◽  
Vol 7 (66) ◽  
pp. 41919-41928 ◽  
Author(s):  
Chaoping Fu ◽  
Rui-Meng Yang ◽  
Li Wang ◽  
Nan-nan Li ◽  
Meng Qi ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hyaluronic Acid ◽  
Iron Oxide ◽  
Surface Functionalization ◽  
Superparamagnetic Nanoparticles ◽  
Liver Carcinoma ◽  
Oxide Nanoparticles ◽  
Doxorubicin Hydrochloride ◽  
Macromolecular Prodrug ◽  
Acid Labile

For combinatorial monitoring and chemotherapy of liver carcinoma, the macromolecular prodrug based on hyaluronic acid and doxorubicin hydrochloride was prepared by an acid-labile linkage and conjugated with amine-modified iron oxide nanoparticles.

scholarly journals Intra-Articular Hyaluronic Acid and Chondroitin Sulfate: Pharmacokinetic Investigation in Osteoarthritic Rat Models

2020 ◽  
Vol 92 ◽  
pp. 100573 ◽  
Author(s):  
Massimiliano Fonsi ◽  
Abdel-Ilah El Amrani ◽  
Frédéric Gervais ◽  
Patrice Vincent
Keyword(s):  
Hyaluronic Acid ◽  
Chondroitin Sulfate ◽  
Rat Models ◽  
Pharmacokinetic Investigation

Healing of Circular Defects in the Rabbit Medial Meniscus Can Occur Spontaneously and Is not Improved by Intra-Articular Hyaluronic Acid

1996 ◽  
Vol 09 (02) ◽  
pp. 60-5 ◽  
Author(s):  
N. Hope ◽  
P. Ghosh ◽  
S. Collier
Keyword(s):  
Hyaluronic Acid ◽  
Medial Meniscus ◽  
Chondroitin Sulphate ◽  
Rabbit Model ◽  
Type Ii Collagen ◽  
Type Ii ◽  
Keratan Sulphate ◽  
Meniscal Healing ◽  
Meniscus Healing ◽  
Made In

SummaryThe aim of this study was to determine the effects of intra-articular hyaluronic acid on meniscal healing. Circular defects, 1.0 mm in diameter, were made in the anterior third of the medial meniscus in rabbits. In one joint, 0.4 ml hyaluronic acid (Healon®) was instilled, and in the contralateral (control) joint, 0.4 ml Ringer’s saline. Four rabbits were killed after four, eight and 12 weeks and the menisci examined histologically. By eight weeks most of the lesions had healed by filling with hyaline-like cartilage. Healing was not improved by hyaluronic acid treatment. The repair tissue stained strongly with alcian blue, and the presence of type II collagen, keratan sulphate, and chondroitin sulphate was demonstrated by immunohistochemical localisation. In contrast to the circular defects, longitudinal incisions made in the medial menisci of a further six rabbits did not show any healing after 12 weeks, indicating that the shape of the lesion largely determined the potential for healing.The effect of hyaluronic acid on meniscal healing was tested in a rabbit model. With one millimeter circular lesions in the medial meniscus, healing by filling with hyalinelike cartilage was not significantly affected by the application of hyaluronic acid intra-articularly at the time of surgery, compared to saline controls, as assessed histologically four, eight and 12 weeks after the operation.

A COMPARISON BETWEEN THE EXOPHTHALMOS INHIBITING EFFECTS OF SODIUM-D- AND SODIUM-L-THYROXINE IN GUINEA PIGS

1962 ◽  
Vol 41 (4) ◽  
pp. 619-624 ◽  
Author(s):  
Björn Tengroth ◽  
Uno Zackrisson
Keyword(s):  
Hyaluronic Acid ◽  
Pituitary Gland ◽  
Guinea Pigs ◽  
Anterior Lobe ◽  
Optical Isomers ◽  
Connective Tissues ◽  
Response Curves ◽  
Experimental Animals ◽  
Inhibiting Effect ◽  
Caloric Effect

ABSTRACT The general change in the connective tissues which occurs in animals with experimentally produced exophthalmos, consists in an increase in the amount of hyaluronic acid, which binds the water in the connective tissue. Many regard this process as a stimulation of the mucinous system in the connective tissues, and consider this an explanation of the phenomenon of exophthalmos. When the experimental animals are injected with thyroxine or thyroid extract, the reaction observed is opposite to that seen following the injection of the anterior lobe of the pituitary gland. In the former case, there is a reduction in the amount of hyaluronic acid and consequently a decrease in the water content in the connective tissues. In the experiments in question, Na-d-thyroxine and Na-l-thyroxine), in crystalline form, were tested for their inhibiting effect on the development of exophthalmos in experimental animals. The animals used were male albino guinea-pigs. An extract of the anterior lobe of the pituitary gland (TSH Organon)) was used to produce exophthalmos. In previous work (Tengroth 1961), it was shown, using an X-ray measuring technique, that d-thyroxine, despite its poor caloric effect, like l-thyroxine had an exophthalmos-inhibiting effect. When comparing the dose-response curves of the exophthalmos-inhibiting properties of both these optical isomers, it appears that d-thyroxine has an inhibiting effect which is significantly greater than that of l-thyroxine. The significance of this observation is discussed.

Modification of Hyaluronic Acid with Hydrazine & Hydrazone; And Using their New Conjugates as Potential Antimicrobial Agents

2011 ◽  
Vol 3 (7) ◽  
pp. 23-26 ◽  
Author(s):  
E. Salah E. Salah ◽  
◽  
R. Ahmed R. Ahmed ◽  
E. Hala E. Hala ◽  
B. Hala B. Hala
Keyword(s):  
Hyaluronic Acid ◽  
Antimicrobial Agents
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