Improved Stability, Antitumor Effect, and Controlled Release of Recombinant Soluble TRAIL by Combining Genetic Engineering with Coaxial Electrospinning

2019 ◽  
Vol 2 (6) ◽  
pp. 2414-2420 ◽  
Author(s):  
Bin Yu ◽  
Xueping Zhang ◽  
Jingyi Yan ◽  
Dong Liu ◽  
Libo Li ◽  
...  
Keyword(s):  
Controlled Release ◽  
Genetic Engineering ◽  
Antitumor Effect ◽  
Coaxial Electrospinning ◽  
Improved Stability ◽  
Soluble Trail

scholarly journals Fabrication of PLA-PEG Nanoparticles as Delivery Systems for Improved Stability and Controlled Release of Catechin

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Neha Atulkumar Singh ◽  
Abul Kalam Azad Mandal ◽  
Zaved Ahmed Khan
Keyword(s):  
Controlled Release ◽  
Delivery System ◽  
Oral Delivery ◽  
Polymeric Nanoparticles ◽  
Double Emulsion ◽  
Hydrodynamic Diameter ◽  
Sem Image ◽  
Oral Delivery System ◽  
Improved Stability

The purpose of this study was to develop an oral delivery system for the controlled release of catechin and evaluate the antioxidant potential and stability of catechin loaded PLA/PEG nanoparticles (CATNP). Nanoparticles were synthesized using a double emulsion solvent evaporation method. The fabricated nanoparticles were relatively small with a hydrodynamic diameter of 300 nm and an encapsulation efficiency of 95%. SEM image analysis showed uniform sized and spherically shaped nanoparticles. In vitro release profiles indicated a slow and sustained release of catechin from the nanoparticle. Stability of the nanoparticle in simulated gastric and intestinal fluids is maintained due to the PEG coating on the nanoparticles, which effectively protected catechin against gastrointestinal enzyme activity. Enhanced inhibition action of free radicals and metal chelation potential was noted when catechin was encapsulated in these polymeric nanoparticles. The reports obtained from this study would provide an opportunity for designing an oral delivery system aimed at inhibiting oxidative stress in the human body.

scholarly journals Microsponge as an Emerging Technique in Novel Drug Delivery System

2021 ◽  
Vol 11 (1) ◽  
pp. 171-182
Author(s):  
Payal D Borawake ◽  
Arumugam Kauslya ◽  
Jitendra V Shinde ◽  
Rajashree S Chavan
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Product Performance ◽  
Topical Drug Delivery ◽  
Polymeric Microspheres ◽  
Current Review ◽  
Improved Stability ◽  
Novel Drug

Numbers of developments are implemented in drug delivery system to achieve the goals of optimized efficacy, cost effectiveness of therapy. One of the latest, novel and highly evolving technologies is microsponge drug delivery system which gives controlled release and site specific delivery of active ingredients. They are highly cross linked, porous and polymeric microspheres with size range of 5-300µm. This system is emerging as valuable option for topical delivery of drugs due to characteristics like decreased side effects, improved stability, better formulation flexibility, superior product performance. It is having number of applications in oral, topical, ocular and biopharmaceuticals delivery. The current review describes microsponge technology and details of the formulation methods, evaluation, programmable release mechanisms and applications.   Keywords: Microsponges; Controlled release; Quasi emulsion solvent diffusion; Programmable drug release; Oral administration; Topical drug delivery.

Controlled Release and Antitumor Effect of Pluronic F127 Mixed with Cisplatin in a Rabbit Model

2009 ◽  
Vol 33 (1) ◽  
pp. 135-142 ◽  
Author(s):  
Akinaga Sonoda ◽  
Norihisa Nitta ◽  
Shinich Ohta ◽  
Ayumi Nitta-Seko ◽  
Shigehiro Morikawa ◽  
...  
Keyword(s):  
Controlled Release ◽  
Antitumor Effect ◽  
Rabbit Model ◽  
Pluronic F127

Controlled release of resveratrol and xanthohumol via coaxial electrospinning fibers

2019 ◽  
Vol 31 (4) ◽  
pp. 456-471 ◽  
Author(s):  
Xue Zhang ◽  
Libin Han ◽  
Qihao Sun ◽  
Wenlong Xia ◽  
Qifeng Zhou ◽  
...  
Keyword(s):  
Controlled Release ◽  
Coaxial Electrospinning

Coaxial electrospinning multicomponent functional controlled-release vascular graft: Optimization of graft properties

2017 ◽  
Vol 152 ◽  
pp. 432-439 ◽  
Author(s):  
Anlin Yin ◽  
Rifang Luo ◽  
Jiukai Li ◽  
Xiumei Mo ◽  
Yunbing Wang ◽  
...  
Keyword(s):  
Controlled Release ◽  
Vascular Graft ◽  
Coaxial Electrospinning
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