Reduced Graphene Oxide Functionalized with Gold Nanostar Nanocomposites for Synergistically Killing Bacteria through Intrinsic Antimicrobial Activity and Photothermal Ablation

2019 ◽  
Vol 2 (2) ◽  
pp. 747-756 ◽  
Author(s):  
Yonghai Feng ◽  
Qingyu Chen ◽  
Qing Yin ◽  
Guoqing Pan ◽  
Zhigang Tu ◽  
...  
2019 ◽  
Vol 7 (17) ◽  
pp. 2771-2781 ◽  
Author(s):  
Milica Budimir ◽  
Roxana Jijie ◽  
Ran Ye ◽  
Alexandre Barras ◽  
Sorin Melinte ◽  
...  

A flexible nanoheater device, consisting of a Au nanohole array coated with reduced graphene oxide–polyethyleneimine, was applied to capture and eradicate both Gram-positive and Gram negative planktonic bacteria and their biofilms.


2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
N. L. V. Carreño ◽  
A. M. Barbosa ◽  
V. C. Duarte ◽  
C. F. Correa ◽  
C. Ferrúa ◽  
...  

Silver-functionalized reduced graphene oxide (Ag-rGO) nanosheets were prepared by single chemical and thermal processes, with very low concentration of silver. The resulting carbon framework consists of reduced graphene oxide (rGO) sheets or 3D networks, decorated with anchored silver nanoparticles. The Ag-rGO nanosheets were dispersed into a polymer matrix and the composites evaluated for use as biological scaffolds. The rGO material in poly(dimethylsiloxane) (PDMS) has been tested for antimicrobial activity against Gram-positiveStaphylococcus aureus(S. Aureus) bacteria, after exposure times of 24 and 120 hours, as well as in the determination of cell viability on cultures of fibroblast cells (NIH/3T3). Using 1 mL of Ag-rGO in PDMS the antibacterial effectiveness againstStaphylococcus aureuswas limited, showing an increased amount of Colony Forming Units (CFU), after 24 hours of contact. In the cell viability assay, after 48 hours of contact, the group of 1 mL of Ag-rGO with PDMS was the only group that increased cell viability when compared to the control group. In this context, it is believed these behaviors are due to the increase in cell adhesion capacity promoted by the rGO. Thus, the Ag-rGO/PDMS hybrid nanocomposite films can be used as scaffolds for tissue engineering, as they limit antimicrobial activity.


2017 ◽  
Vol 4 (2) ◽  
pp. 025401 ◽  
Author(s):  
Rajveer Singh Rajaura ◽  
Vinay Sharma ◽  
Rishabh Shrivastava Ronin ◽  
Deepak K Gupta ◽  
Subodh Srivastava ◽  
...  

2020 ◽  
Vol 5 (1) ◽  
pp. 5-12
Author(s):  
Milica Budimir ◽  
Duška Kleut ◽  
Biljana Todorovic Markovic ◽  
Rabah Boukherroub

AbstractOne of the major public health concerns today is bacterial infection-associated diseases. Traditional antibacterial therapies are becoming less efficient because frequent and inadequate use of antibiotics has caused mutations in bacteria that led to many antibiotic-resistant bacterial strains. It is, therefore, crucial to develop novel antibacterial materials and strategies that will successfully combat both gram-positive and gram-negative bacteria. In the present study, we will demonstrate a simple and efficient method for bacteria capture and elimination through photothermal ablation. The developed material consists of a flexible Kapton substrate, coated with reduced graphene oxide-chitosan (rGO-CS) thin films. Reduced graphene oxide has strong absorption in the near-infrared (NIR) region, while chitosan has the ability to bind bacteria through electrostatic interactions. The K/rGO-CS device proved to capture and efficiently eradicate both planktonic Gram-positive Staphylococcus aureus (S. aureus) and Gram-negative Escherichia coli (E. coli) bacteria after 10 min of NIR (980 nm) irradiation.


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