Protective Activity of Silk Sericin against UV Radiation-Induced Skin Damage by Downregulating Oxidative Stress

2018 ◽  
Vol 1 (6) ◽  
pp. 2120-2132 ◽  
Author(s):  
Jadi Praveen Kumar ◽  
Shamshad Alam ◽  
Abhishek Kumar Jain ◽  
Kausar Mahmood Ansari ◽  
Biman B. Mandal
Keyword(s):  
Oxidative Stress ◽  
Uv Radiation ◽  
Protective Activity ◽  
Skin Damage ◽  
Silk Sericin ◽  
Radiation Induced

scholarly journals The inhibitory effect of silk sericin against ultraviolet-induced melanogenesis and its potential use in cosmeceutics as an anti-hyperpigmentation compound

2019 ◽  
Vol 18 (10) ◽  
pp. 2497-2508 ◽  
Author(s):  
Jadi Praveen Kumar ◽  
Biman B. Mandal
Keyword(s):  
Uv Radiation ◽  
Inhibitory Effect ◽  
Silk Sericin ◽  
Radiation Induced ◽  
Potential Use

A schematic illustration of the inhibitory effect of silk sericin against UV radiation-induced melanogenesis.

scholarly journals Flavonols Protect Against UV Radiation-Induced Thymine Dimer Formation in an Artificial Skin Mimic

2015 ◽  
Vol 18 (4) ◽  
pp. 600 ◽  
Author(s):  
Sabia Maini ◽  
Brian M. Fahlman ◽  
Ed S. Krol
Keyword(s):  
Uv Radiation ◽  
Artificial Skin ◽  
Uvb Radiation ◽  
Skin Damage ◽  
Dimer Formation ◽  
Thymine Dimer ◽  
Matrix Metalloproteinase 1 ◽  
Pyrimidine Dimers ◽  
Limit Of Quantitation ◽  
Radiation Induced

Purpose: Exposure of skin to ultraviolet light has been shown to have a number of deleterious effects including photoaging, photoimmunosuppression and photoinduced DNA damage which can lead to the development of skin cancer.  In this paper we present a study on the ability of three flavonols to protect EpiDerm™, an artificial skin mimic, against UV-induced damage. Methods: EpiDerm™ samples were treated with flavonol in acetone and exposed to UVA (100 kJ/m2 at 365 nm) and UVB (9000 J/m2 at 310 nm) radiation.  Secretion of matrix metalloproteinase-1 (MMP-1) and tumor necrosis factor-α (TNF-a) were determined by ELISA, cyclobutane pyrimidine dimers were quantified using LC-APCI-MS. Results: EpiDerm ™ treated topically with quercetin significantly decreased MMP-1 secretion induced by UVA (100 µM) or UVB (200 µM) and TNF-a secretion was significantly reduced at 100 µM quercetin for both UVA and UVB radiation.  In addition, topically applied quercetin was found to be photostable over the duration of the experiment.  EpiDerm™ samples were treated topically with quercetin, kaempferol or galangin (52 µM) immediately prior to UVA or UVB exposure, and the cyclobutane thymine dimers (T-T (CPD)) were quantified using an HPLC-APCI MS/MS method.  All three flavonols significantly decreased T-T (CPD) formation in UVB irradiated EpiDerm™, however no effect could be observed for the UVA irradiation experiments as thymine dimer formation was below the limit of quantitation.  Conclusions: Our results suggest that flavonols can provide protection against UV radiation-induced skin damage through both antioxidant activity and direct photo-absorption. This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.

scholarly journals Skin delivery of epigallocatechin-3-gallate (EGCG) and hyaluronic acid loaded nano-transfersomes for antioxidant and anti-aging effects in UV radiation induced skin damage

Drug Delivery ◽  
2017 ◽  
Vol 24 (1) ◽  
pp. 61-74 ◽  
Author(s):  
Kiran S. Avadhani ◽  
Jyothsna Manikkath ◽  
Mradul Tiwari ◽  
Misra Chandrasekhar ◽  
Ashok Godavarthi ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Uv Radiation ◽  
Skin Damage ◽  
Aging Effects ◽  
Skin Delivery ◽  
Radiation Induced

Mice drinking goji berry juice (Lycium barbarum) are protected from UV radiation-induced skin damage via antioxidant pathways

2010 ◽  
Vol 9 (4) ◽  
pp. 601 ◽  
Author(s):  
Vivienne E. Reeve ◽  
Munif Allanson ◽  
Sondur Jayappa Arun ◽  
Diane Domanski ◽  
Nicole Painter
Keyword(s):  
Uv Radiation ◽  
Skin Damage ◽  
Lycium Barbarum ◽  
Goji Berry ◽  
Radiation Induced

Lipoxin A4 inhibits UV radiation-induced skin inflammation and oxidative stress in mice

2018 ◽  
Vol 91 (2) ◽  
pp. 164-174 ◽  
Author(s):  
R.M. Martinez ◽  
V. Fattori ◽  
P. Saito ◽  
C.B.P. Melo ◽  
S.M. Borghi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Uv Radiation ◽  
Skin Inflammation ◽  
Lipoxin A4 ◽  
Radiation Induced ◽  
And Oxidative Stress
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