Reversibly Reconfigurable Cross-Linking Induces Fusion of Separate Chitosan Hydrogel Films

2018 ◽  
Vol 1 (5) ◽  
pp. 1695-1704 ◽  
Author(s):  
Huimin He ◽  
Jinyang Li ◽  
Xiaodong Cao ◽  
Changshun Ruan ◽  
Qi Feng ◽  
...  
Keyword(s):  
Cross Linking ◽  
Chitosan Hydrogel ◽  
Hydrogel Films

Hypromellose succinate-crosslinked chitosan hydrogel films for potential wound dressing

2016 ◽  
Vol 91 ◽  
pp. 85-91 ◽  
Author(s):  
Qiong Jiang ◽  
Wei zhou ◽  
Jun Wang ◽  
Rupei Tang ◽  
Di Zhang ◽  
...  
Keyword(s):  
Wound Dressing ◽  
Chitosan Hydrogel ◽  
Crosslinked Chitosan ◽  
Hydrogel Films

scholarly journals Polyamide fabric coated with a dihydroxyacetone-loaded chitosan hydrogel for a cosmeto-textile application

2019 ◽  
Vol 50 (4) ◽  
pp. 526-542
Author(s):  
Isabel Solé ◽  
Susana Vílchez ◽  
Núria Montanyà ◽  
Maria José García-Celma ◽  
Marcela Ferrándiz ◽  
...  
Keyword(s):  
Active Component ◽  
Optical Microscope ◽  
Dark Field ◽  
Cross Linking ◽  
Dialysis Membrane ◽  
Chitosan Hydrogel ◽  
Evaluation Panel ◽  
Polyamide Fabric ◽  
Chitosan Hydrogels ◽  
Cryogenic Scanning Electron Microscopy

Cosmeto-textiles, which allow the administration of molecules when in contact with the skin, are increasingly being developed by cosmetic industries. We have designed an innovative approach for cosmeto-textile products, based on the impregnation of textile fibers with chitosan hydrogels, which have been cross-linked with genipin and loaded with dihydroxyacetone, which is an active component that induces sunless tanning. Dihydroxyacetone-loaded chitosan hydrogels have been prepared and characterized by means of cryogenic scanning electron microscopy (cryo-SEM). The images showed that genipin cross-linking decreases the mesh distance of hydrogels. The release of dihydroxyacetone from these cross-linked genipin chitosan hydrogels has been studied by a dialysis membrane method. These dihydroxyacetone-loaded chitosan hydrogels have been incorporated to polyamide textiles by a simple padding technique. The presence of dihydroxyacetone on these textiles has been detected by hyperspectral imaging on a dark field high resolution optical microscope. Finally, the performance of fabrics as cosmeto-textiles, with a tanning effect, has been evaluated by skin-colorimetry measured with an evaluation panel of 10 people. The results have demonstrated that dihydroxyacetone-loaded textiles produce a tanning effect on skin, and incorporation of dihydroxyacetone-loaded chitosan hydrogels into polyamide fabrics represents a friendly and appropriate strategy to obtain a cosmeto-textile with tanning effect.

Characterization and enzymatic degradation of PEG-cross-linked chitosan hydrogel films

2009 ◽  
Vol 114 (3) ◽  
pp. 1902-1907 ◽  
Author(s):  
Hiroaki Tanuma ◽  
Hiroki Kiuchi ◽  
Weihua Kai ◽  
Koji Yazawa ◽  
Yoshio Inoue
Keyword(s):  
Enzymatic Degradation ◽  
Chitosan Hydrogel ◽  
Hydrogel Films

Carboxyl-modified poly(vinyl alcohol)-crosslinked chitosan hydrogel films for potential wound dressing

2015 ◽  
Vol 125 ◽  
pp. 189-199 ◽  
Author(s):  
Di Zhang ◽  
Wei Zhou ◽  
Bing Wei ◽  
Xin Wang ◽  
Rupei Tang ◽  
...  
Keyword(s):  
Vinyl Alcohol ◽  
Wound Dressing ◽  
Poly Vinyl Alcohol ◽  
Chitosan Hydrogel ◽  
Crosslinked Chitosan ◽  
Hydrogel Films

scholarly journals Preparation of Cross-linked Chitosan Quaternary Ammonium Salt Hydrogel Films Loading Drug of Gentamicin Sulfate for Antibacterial Wound Dressing

Marine Drugs ◽  
2021 ◽  
Vol 19 (9) ◽  
pp. 479
Author(s):  
Jingjing Zhang ◽  
Wenqiang Tan ◽  
Qing Li ◽  
Xiaorui Liu ◽  
Zhanyong Guo
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Antibacterial Activity ◽  
Ammonium Salt ◽  
Quaternary Ammonium ◽  
Quaternary Ammonium Salt ◽  
Wound Dressing ◽  
Cross Linking ◽  
And Staphylococcus Aureus ◽  
Hydrogel Films

Hydrogels, possessing high biocompatibility and adaptability to biological tissue, show great usability in medical applications. In this research, a series of novel cross-linked chitosan quaternary ammonium salt loading with gentamicin sulfate (CTMCSG) hydrogel films with different cross-linking degrees were successfully obtained by the reaction of chitosan quaternary ammonium salt (TMCS) and epichlorohydrin. Fourier transform infrared spectroscopy (FTIR), thermal analysis, and scanning electron microscope (SEM) were used to characterize the chemical structure and surface morphology of CTMCSG hydrogel films. The physicochemical property, gentamicin sulphate release behavior, cytotoxicity, and antibacterial activity of the CTMCSG against Escherichia coli and Staphylococcus aureus were determined. Experimental results demonstrated that CTMCSG hydrogel films exhibited good water stability, thermal stability, drug release capacity, as well as antibacterial property. The inhibition zone of CTMCSG hydrogel films against Escherichia coli and Staphylococcus aureus could be up to about 30 mm. Specifically, the increases in maximum decomposition temperature, mechanical property, water content, swelling degree, and a reduction in water vapor permeability of the hydrogel films were observed as the amount of the cross-linking agent increased. The results indicated that the CTMCSG-4 hydrogel film with an interesting physicochemical property, admirable antibacterial activity, and slight cytotoxicity showed the potential value as excellent antibacterial wound dressing.

Design and fabrication of a chitosan hydrogel with gradient structures via a step-by-step cross-linking process

2017 ◽  
Vol 176 ◽  
pp. 195-202 ◽  
Author(s):  
Yongxiang Xu ◽  
Shenpo Yuan ◽  
Jianmin Han ◽  
Hong Lin ◽  
Xuehui Zhang
Keyword(s):  
Cross Linking ◽  
Chitosan Hydrogel

pH-Sensitivity of N-Carboxyethyl Chitosan Hydrogel and Drug Controlled Release In Vitro

2007 ◽  
Vol 561-565 ◽  
pp. 1455-1458
Author(s):  
Zuo Wei Li ◽  
Li Yan Zhang ◽  
Qing Xiao Zeng
Keyword(s):  
Bovine Serum Albumin ◽  
Acrylic Acid ◽  
Nmr Spectra ◽  
Cross Linking ◽  
Intestinal Fluid ◽  
Chitosan Hydrogel ◽  
Drug Controlled Release ◽  
Swelling Rate ◽  
Grafting Degree

N-carboxyethyl chitosan (ACS) was formed by a Micheal reaction. Through the analysis of IR and 1H-NMR spectra, the Micheal reaction was carried out between - NH2 of chitosan and - C = C - of acrylic acid. ACS hydrogel (ACSG) was prepared by cross-linking with glutaraldehyde. ACSG show pH-sensitive swelling behavior, and the smallest swelling rate (SR) of ACSG is in pH5.0 buffer solution.With dosage of glutaraldehyde increasing, the SR of ACSG decreased. With grafting degree (GD) increasing, the SR of ACSG increased first and decreased afterward. Using bovine serum albumin (BSA) as a model medicine, the releasing behaviors of ACSG were investigated in vitro. In simulated gastric and intestinal fluid, the ACSG loading BSA (GD=20.45%) has better releasing behaviors.

scholarly journals Hydrogel Films Based on Chitosan and Oxidized Carboxymethylcellulose Optimized for the Controlled Release of Curcumin with Applications in Treating Dermatological Conditions

Molecules ◽  
2021 ◽  
Vol 26 (8) ◽  
pp. 2185
Author(s):  
Mohamed Dellali ◽  
Camelia Elena Iurciuc (Tincu) ◽  
Corina Lenuța Savin ◽  
Nawel Spahis ◽  
M’hamed Djennad ◽  
...  
Keyword(s):  
Carboxymethyl Cellulose ◽  
Molar Ratio ◽  
Cross Linking ◽  
Oxidation Degree ◽  
Molar Ratios ◽  
Receptor Compartment ◽  
Index Value ◽  
Aldehyde Groups ◽  
Hydrogel Films

Cross-linked chitosan (CS) films with aldehyde groups obtained by oxidation of carboxymethyl cellulose (CMC) with NaIO4 were prepared using different molar ratios between the CHO groups from oxidized carboxymethyl cellulose (CMCOx) and NH2 groups from CS (from 0.25:1 to 2:1). Fourier-transform infrared (FTIR) and nuclear magnetic resonance (NMR) spectroscopy demonstrated the aldehyde groups’ presence in the CMCOx. The maximum oxidation degree was 22.9%. In the hydrogel, the amino groups’ conversion index value increased when the -CHO/-NH2 molar ratio, cross-linking temperature, and time increased, while the swelling degree values decreased. The hydrogel films were characterized by scanning electron microscopy (SEM) and FTIR analysis. The curcumin encapsulation efficiency decreases from 56.74% to 16.88% when the cross-linking degree increases. The immobilized curcumin release efficiency (REf%) and skin membrane permeability were evaluated in vitro in two different pH solutions using a Franz diffusion cell, and it was found to decrease when the molar ratio -CH=O/NH2 increases. The curcumin REf% in the receptor compartment was higher at pH = 7.4 (18%- for the sample with a molar ratio of 0.25:1) than at pH = 5.5 (16.5%). The curcumin absorption in the skin membrane at pH = 5.5 (47%) was more intense than at pH = 7.4 (8.6%). The curcumin-loaded films’ antioxidant activity was improved due to the CS presence.

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