Reduced Graphene Oxide-Zirconium Dioxide–Thionine Nanocomposite Integrating Recognition, Amplification, and Signaling for an Electrochemical Assay of Protein Kinase Activity and Inhibitor Screening

2018 ◽  
Vol 1 (5) ◽  
pp. 1557-1565 ◽  
Author(s):  
Zhiqiang Chen ◽  
Ying Liu ◽  
Lijie Hao ◽  
Zhencai Zhu ◽  
Fang Li ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Protein Kinase ◽  
Reduced Graphene Oxide ◽  
Zirconium Dioxide ◽  
Kinase Activity ◽  
Protein Kinase Activity ◽  
Electrochemical Assay ◽  
Inhibitor Screening ◽  
Reduced Graphene

scholarly journals Reduced graphene oxide and inorganic nanoparticles composites – synthesis and characterization

2015 ◽  
Vol 17 (4) ◽  
pp. 95-103 ◽  
Author(s):  
Magdalena Onyszko ◽  
Karolina Urbas ◽  
Malgorzata Aleksandrzak ◽  
Ewa Mijowska
Keyword(s):  
Graphene Oxide ◽  
Metal Oxide ◽  
Reduced Graphene Oxide ◽  
Zirconium Dioxide ◽  
Water Solution ◽  
Metal Oxide Nanoparticles ◽  
Direct Synthesis ◽  
Inorganic Nanoparticles ◽  
Oxide Nanoparticles ◽  
Reduced Graphene

Abstract Graphene – novel 2D material, which possesses variety of fascinating properties, can be considered as a convenient support material for the nanoparticles. In this work various methods of synthesis of reduced graphene oxide with metal or metal oxide nanoparticles will be presented. The hydrothermal approach for deposition of platinum, palladium and zirconium dioxide nanoparticles in ethylene glycol/water solution was applied. Here, platinum/reduced graphene oxide (Pt/RGO), palladium/reduced graphene oxide (Pd/RGO) and zirconium dioxide/reduced graphene oxide (ZrO2/RGO) nanocomposites were prepared. Additionally, manganese dioxide/reduced graphene oxide nanocomposite (MnO2/RGO) was synthesized in an oleic-water interface. The obtained nanocomposites were investigated by transmission electron microscopy (TEM), X-ray diffraction analysis (XRD), Raman spectroscopy and thermogravimetric analysis (TGA). The results shows that GO can be successfully used as a template for direct synthesis of metal or metal oxide nanoparticles on its surface with a homogenous distribution.

A robust and quantitative assay platform for multiplexed, high throughput screening of protein kinase inhibitors

2016 ◽  
Vol 52 (81) ◽  
pp. 12112-12115 ◽  
Author(s):  
Jieon Lee ◽  
Il-Soo Park ◽  
Ginam Park ◽  
Kyukwang Cho ◽  
Hee-Sung Park ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Protein Kinase ◽  
High Throughput ◽  
High Throughput Screening ◽  
Kinase Activity ◽  
Kinase Inhibitors ◽  
Protein Kinase Inhibitors ◽  
Protein Kinase Activity ◽  
Activity Assay ◽  
Kinase Activity Assay

We present a new platform for multiplexed protein kinase activity assay using TiO2decorated graphene oxide (GO), which is applicable to high throughput inhibitor screening.

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