Synthesis and in Vivo Behavior of PVP/CMC/Agar Hydrogel Membranes Impregnated with Silver Nanoparticles for Wound Healing Applications

2018 ◽  
Vol 1 (6) ◽  
pp. 1842-1852 ◽  
Author(s):  
Gabriel G. de Lima ◽  
Darlla W. F. de Lima ◽  
Maria J. A. de Oliveira ◽  
Ademar B. Lugão ◽  
Mara T. S. Alcântara ◽  
...  
Keyword(s):  
Wound Healing ◽  
Silver Nanoparticles ◽  
Hydrogel Membranes

Wound healing of nanofiber comprising Polygalacturonic/Hyaluronic acid embedded silver nanoparticles: In-vitro and in-vivo studies

2020 ◽  
Vol 238 ◽  
pp. 116175 ◽  
Author(s):  
M.R. El-Aassar ◽  
Omar M. Ibrahim ◽  
Moustafa M.G. Fouda ◽  
Nagham G. El-Beheri ◽  
Mona M. Agwa
Keyword(s):  
Wound Healing ◽  
Silver Nanoparticles ◽  
Hyaluronic Acid ◽  
In Vivo Studies

scholarly journals In Vivo Study of the Antibacterial Chitosan/Polyvinyl Alcohol Loaded with Silver Nanoparticle Hydrogel for Wound Healing Applications

2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Tan Dat Nguyen ◽  
Thanh Truc Nguyen ◽  
Khanh Loan Ly ◽  
Anh Hien Tran ◽  
Thi Thanh Ngoc Nguyen ◽  
...  
Keyword(s):  
Wound Healing ◽  
Silver Nanoparticles ◽  
Antibacterial Activity ◽  
Polyvinyl Alcohol ◽  
Healing Rate ◽  
Antibacterial Effects ◽  
Topical Gel ◽  
Significant Difference

Silver nanoparticles have attracted great interests widely in medicine due to its great characteristics of antibacterial activity. In this research, the antibacterial activity and biocompatibility of a topical gel synthesized from polyvinyl alcohol, chitosan, and silver nanoparticles were studied. Hydrogels with different concentrations of silver nanoparticles (15 ppm, 30 ppm, and 60 ppm) were evaluated to compare their antibacterial activity, nanoparticles’ sizes, and in vivo behaviors. The resulted silver nanoparticles in the hydrogel were characterized by TEM showing the nanoparticles’ sizes less than 22 nm. The in vitro results prove that the antibacterial effects of all of the samples are satisfied. However, the in vivo results demonstrate the significant difference among different hydrogels in wound healing, where hydrogel with 30 ppm shows the best healing rate.

scholarly journals Silver Nanoparticles-Composing Alginate/Gelatine Hydrogel Improves Wound Healing In Vivo

Nanomaterials ◽  
2020 ◽  
Vol 10 (2) ◽  
pp. 390 ◽  
Author(s):  
Flavia Resende Diniz ◽  
Romerito Cesar A. P. Maia ◽  
Lucas Rannier Andrade ◽  
Luciana Nalone Andrade ◽  
Marco Vinicius Chaud ◽  
...  
Keyword(s):  
Wound Healing ◽  
Silver Nanoparticles ◽  
Sodium Alginate ◽  
Time Course ◽  
In Vivo Studies ◽  
Natural Polymers ◽  
Cutaneous Lesions ◽  
Cutaneous Wounds ◽  
Healing Tissue

Polymer hydrogels have been suggested as dressing materials for the treatment of cutaneous wounds and tissue revitalization. In this work, we report the development of a hydrogel composed of natural polymers (sodium alginate and gelatin) and silver nanoparticles (AgNPs) with recognized antimicrobial activity for healing cutaneous lesions. For the development of the hydrogel, different ratios of sodium alginate and gelatin have been tested, while different concentrations of AgNO3 precursor (1.0, 2.0, and 4.0 mM) were assayed for the production of AgNPs. The obtained AgNPs exhibited a characteristic peak between 430–450 nm in the ultraviolet-visible (UV–Vis) spectrum suggesting a spheroidal form, which was confirmed by Transmission Electron Microscopy (TEM). Fourier Transform Infra-red (FT–IR) analysis suggested the formation of strong intermolecular interactions as hydrogen bonds and electrostatic attractions between polymers, showing bands at 2920, 2852, 1500, and 1640 cm−1. Significant bactericidal activity was observed for the hydrogel, with a Minimum Inhibitory Concentration (MIC) of 0.50 µg/mL against Pseudomonas aeruginosa and 53.0 µg/mL against Staphylococcus aureus. AgNPs were shown to be non-cytotoxic against fibroblast cells. The in vivo studies in female Wister rats confirmed the capacity of the AgNP-loaded hydrogels to reduce the wound size compared to uncoated injuries promoting histological changes in the healing tissue over the time course of wound healing, as in earlier development and maturation of granulation tissue. The developed hydrogel with AgNPs has healing potential for clinical applications.

Carbohydrate-Coated Gold–Silver Nanoparticles for Efficient Elimination of Multidrug Resistant Bacteria and in Vivo Wound Healing

2019 ◽  
Vol 11 (46) ◽  
pp. 42998-43017 ◽  
Author(s):  
Satish Kumar ◽  
Rakesh Kumar Majhi ◽  
Abhishek Singh ◽  
Mitali Mishra ◽  
Ankit Tiwari ◽  
...  
Keyword(s):  
Wound Healing ◽  
Silver Nanoparticles ◽  
Multidrug Resistant ◽  
Resistant Bacteria ◽  
Multidrug Resistant Bacteria ◽  
Gold Silver ◽  
Efficient Elimination

An investigation of in vivo wound healing activity of biologically synthesized silver nanoparticles

2014 ◽  
Vol 16 (9) ◽  
Author(s):  
Abhishek Kaler ◽  
Amit Kumar Mittal ◽  
Mahesh Katariya ◽  
Harshad Harde ◽  
Ashish Kumar Agrawal ◽  
...  
Keyword(s):  
Wound Healing ◽  
Silver Nanoparticles ◽  
Wound Healing Activity

In vivo efficacy of biocompatible silver nanoparticles cream for empirical wound healing

2018 ◽  
Vol 27 (4) ◽  
pp. 257-261 ◽  
Author(s):  
Asra Parveen ◽  
Neha Kulkarni ◽  
Manjunath Yalagatti ◽  
Venkataraman Abbaraju ◽  
Raghunandan Deshpande
Keyword(s):  
Wound Healing ◽  
Silver Nanoparticles ◽  
In Vivo Efficacy
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