Photonic Crystal-Embedded Molecularly Imprinted Contact Lenses for Controlled Drug Release

2021 ◽  
Author(s):  
Zhaoran Chu ◽  
Chao Xue ◽  
Kan Shao ◽  
Lanlan Xiang ◽  
Xueling Zhao ◽  
...  
Keyword(s):  
Photonic Crystal ◽  
Drug Release ◽  
Contact Lenses ◽  
Controlled Drug Release ◽  
Molecularly Imprinted

scholarly journals Reduction-Responsive Molecularly Imprinted Poly(2-isopropenyl-2-oxazoline) for Controlled Release of Anticancer Agents

Pharmaceutics ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 506 ◽  
Author(s):  
Michał Cegłowski ◽  
Valentin Victor Jerca ◽  
Florica Adriana Jerca ◽  
Richard Hoogenboom
Keyword(s):  
Controlled Release ◽  
Drug Release ◽  
Anticancer Agents ◽  
Release Kinetics ◽  
Controlled Drug Release ◽  
Release Mechanism ◽  
Molecularly Imprinted ◽  
Responsive Materials ◽  
Future Work ◽  
Specific Trigger

Trigger-responsive materials are capable of controlled drug release in the presence of a specific trigger. Reduction induced drug release is especially interesting as the reductive stress is higher inside cells than in the bloodstream, providing a conceptual controlled release mechanism after cellular uptake. In this work, we report the synthesis of 5-fluorouracil (5-FU) molecularly imprinted polymers (MIPs) based on poly(2-isopropenyl-2-oxazoline) (PiPOx) using 3,3′-dithiodipropionic acid (DTDPA) as a reduction-responsive functional cross-linker. The disulfide bond of DTDPA can be cleaved by the addition of tris(2-carboxyethyl)phosphine (TCEP), leading to a reduction-induced 5-FU release. Adsorption isotherms and kinetics for 5-FU indicate that the adsorption kinetics process for imprinted and non-imprinted adsorbents follows two different kinetic models, thus suggesting that different mechanisms are responsible for adsorption. The release kinetics revealed that the addition of TCEP significantly influenced the release of 5-FU from PiPOx-MIP, whereas for non-imprinted PiPOx, no statistically relevant differences were observed. This work provides a conceptual basis for reduction-induced 5-FU release from molecularly imprinted PiPOx, which in future work may be further developed into MIP nanoparticles for the controlled release of therapeutic agents.

Co-delivery of timolol and hyaluronic acid from semi-circular ring-implanted contact lenses for the treatment of glaucoma: in vitro and in vivo evaluation

2018 ◽  
Vol 6 (6) ◽  
pp. 1580-1591 ◽  
Author(s):  
Ankita R. Desai ◽  
Furqan A. Maulvi ◽  
Mihir M. Pandya ◽  
Ketan M. Ranch ◽  
Bhavin A. Vyas ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Drug Release ◽  
Contact Lenses ◽  
Controlled Drug Release ◽  
Circular Ring ◽  
In Vivo Evaluation

Controlled drug release from semi-circular drug-loaded ring-implanted contact lenses.

scholarly journals Controlled drug release from hydrogels for contact lenses: Drug partitioning and diffusion

2016 ◽  
Vol 515 (1-2) ◽  
pp. 467-475 ◽  
Author(s):  
A.F.R. Pimenta ◽  
J. Ascenso ◽  
J.C.S. Fernandes ◽  
R. Colaço ◽  
A.P. Serro ◽  
...  
Keyword(s):  
Drug Release ◽  
Contact Lenses ◽  
Controlled Drug Release ◽  
Drug Partitioning ◽  
And Diffusion

The controlled drug release by pH-sensitive molecularly imprinted nanospheres for enhanced antibacterial activity

2017 ◽  
Vol 77 ◽  
pp. 84-91 ◽  
Author(s):  
Congyang Mao ◽  
Xianzhou Xie ◽  
Xiangmei Liu ◽  
Zhenduo Cui ◽  
Xianjin Yang ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Drug Release ◽  
Controlled Drug Release ◽  
Ph Sensitive ◽  
Molecularly Imprinted

Reducing the Risk in Controlled Drug Release by Using Tannic Acid in Liposomal Formulations

2018 ◽  
Vol 68 (12) ◽  
pp. 2925-2918
Author(s):  
Gabriela Cioca ◽  
Maricel Agop ◽  
Marcel Popa ◽  
Simona Bungau ◽  
Irina Butuc
Keyword(s):  
Drug Release ◽  
Tannic Acid ◽  
Release Rate ◽  
Controlled Drug Release ◽  
Toxicity Threshold ◽  
Release System ◽  
Liposomal Formulations ◽  
Cross Linker ◽  
Natural Cross

One of the main challenges in designing a release system is the possibility to control the release rate in order to maintain it at a constant value below a defined limit, to avoid exceeding the toxicity threshold. We propose a method of overcoming this difficulty by introducing the drug into liposomes, prior to its inclusion in the hydrogel. Furthermore, a natural cross linker (as is tannic acid) is used, instead of the toxic cross linkers commonly used, thus reducing the toxicity of the release system as a whole.

Nanostructured Ketorolac-Tromethamine/MCF: Synthesis, Characterization and Application in Drug Release System

2018 ◽  
Vol 14 (5) ◽  
pp. 432-439 ◽  
Author(s):  
Juliana M. Juarez ◽  
Jorgelina Cussa ◽  
Marcos B. Gomez Costa ◽  
Oscar A. Anunziata
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Therapeutic Efficacy ◽  
Drug Delivery Systems ◽  
Controlled Drug Release ◽  
Delivery Systems ◽  
The Body ◽  
Fickian Diffusion ◽  
Ketorolac Tromethamine

Background: Controlled drug delivery systems can maintain the concentration of drugs in the exact sites of the body within the optimum range and below the toxicity threshold, improving therapeutic efficacy and reducing toxicity. Mesostructured Cellular Foam (MCF) material is a new promising host for drug delivery systems due to high biocompatibility, in vivo biodegradability and low toxicity. Methods: Ketorolac-Tromethamine/MCF composite was synthesized. The material synthesis and loading of ketorolac-tromethamine into MCF pores were successful as shown by XRD, FTIR, TGA, TEM and textural analyses. Results: We obtained promising results for controlled drug release using the novel MCF material. The application of these materials in KETO release is innovative, achieving an initial high release rate and then maintaining a constant rate at high times. This allows keeping drug concentration within the range of therapeutic efficacy, being highly applicable for the treatment of diseases that need a rapid response. The release of KETO/MCF was compared with other containers of KETO (KETO/SBA-15) and commercial tablets. Conclusion: The best model to fit experimental data was Ritger-Peppas equation. Other models used in this work could not properly explain the controlled drug release of this material. The predominant release of KETO from MCF was non-Fickian diffusion.

Sign in / Sign up

Export Citation Format

Share Document