Porous Silica Nanospheres with a Confined Mono(aquated) Mn(II)-Complex: A Potential T1–T2 Dual Contrast Agent for Magnetic Resonance Imaging

2021 ◽  
Author(s):  
Riya Mallik ◽  
Muktashree Saha ◽  
Chandan Mukherjee
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agent ◽  
Porous Silica ◽  
Silica Nanospheres ◽  
Resonance Imaging

scholarly journals Magnetic resonance thermometry using a GdIII-based contrast agent

2021 ◽  
Vol 57 (14) ◽  
pp. 1770-1773
Author(s):  
S. A. Amali S. Subasinghe ◽  
Jonathan Romero ◽  
Cassandra L. Ward ◽  
Matthew D. Bailey ◽  
Donna R. Zehner ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agent ◽  
Contrast Agents ◽  
Resonance Imaging ◽  
Magnetic Resonance Thermometry

The complexes described here serve as contrast agents for magnetic resonance imaging thermometry.

scholarly journals Silica-Coated Fe3O4 Nanoparticles as a Bifunctional Agent for Magnetic Resonance Imaging and ZnII Fluorescent Sensing

2021 ◽  
Vol 20 ◽  
pp. 153303382110365
Author(s):  
Lin Qiu ◽  
Shuwen Zhou ◽  
Ying Li ◽  
Wen Rui ◽  
Pengfei Cui ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agent ◽  
Quantum Interference ◽  
Inductively Coupled Plasma ◽  
Fluorescence Emission ◽  
Mri Contrast Agent ◽  
Core Shell ◽  
Resonance Imaging

Bifunctional magnetic/fluorescent core-shell silica nanospheres (MNPs) encapsulated with the magnetic Fe3O4 core and a derivate of 8-amimoquinoline (N-(quinolin-8-yl)-2-(3-(triethoxysilyl) propylamino) acetamide) (QTEPA) into the shell were synthesized. These functional MNPs were prepared with a modified stöber method and the formed Fe3O4@SiO2-QTEPA core-shell nanocomposites are biocompatible, water-dispersible, and stable. These prepared nanoparticles were characterized by X-ray power diffraction (XRD), transmission electron microscopy (TEM), thermoelectric plasma Quad II inductively coupled plasma mass spectrometry (ICP-MS), superconducting quantum interference device (SQUID), TG/DTA thermal analyzer (TGA) and Fourier transform infrared spectroscopy (FTIR). Further application of the nanoparticles in detecting Zn2+ was confirmed by the fluorescence experiment: the nanosensor shows high selectivity and sensitivity to Zn2+ with a 22-fold fluorescence emission enhancement in the presence of 10 μM Zn2+. Moreover, the transverse relaxivity measurements show that the core-shell MNPs have T2 relaxivity (r2) of 155.05 mM−1 S−1 based on Fe concentration on the 3.0 T scanner, suggesting that the compound can be used as a negative contrast agent for MRI. Further in vivo experiments showed that these MNPs could be used as MRI contrast agent. Therefore, the new nanosensor provides the dual modality of magnetic resonance imaging and optical imaging.

Contrast-agent free evaluation of cardiomyopathies with T1 mapping and the new fast strain-encoded (fSENC) magnetic resonance imaging

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
K Hirschberg ◽  
O Paul ◽  
J Salatzki ◽  
F Andre ◽  
J Riffel ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agent ◽  
T1 Mapping ◽  
Hypertensive Heart Disease ◽  
Study Groups ◽  
Resonance Imaging ◽  
Gadolinium Enhancement ◽  
Scan Time ◽  
Normal Individuals

Abstract Background Cardiomyopathies (CMP) may cause impairment of cardiac function and structure. Cardiac Magnetic Resonance Imaging (CMR) is used for analysis and risk stratification of CMP by Late Gadolinium Enhancement (LGE). However, T1 mapping (T1) and fast strain encoded (f-SENC) sequences allow contrast-free and faster exams. The aim of this study was to characterize CMP by T1 and f-SENC to develop a faster and safer CMR protocol (fast-CMR). Methods CMP scans from our CMR database were retrospectively analyzed. All patients were scanned at 1.5T/3T scanner. Study groups were divided as follows: Patients with normal findings, dilated cardiomyopathy (DCM), hypertrophic cardiomyopathy (HCM), hypertensive heart disease (HHD) and cardiac amyloidosis. Global T1 times, longitudinal (GLS) and circumferential (GCS) strain using f-SENC of study groups were compared to healthy individuals (controls). Scan time and amount of gadolinium-based contrast agent (CA) in CMR-protocol with LGE were compared to fast-CMR. Results 174 patients and 31 controls were recruited. T1 times, GLS and GCS were similar between controls and normal individuals. T1 times were significantly increased (p<0.05), while GLS and GCS were significantly reduced (p<0.05) in all CMR study groups compared to controls (Table 1). Using fast-CMR 21 (±6) min of scan time were saved, about 47%, and 9 (±2) ml of CA were saved per patient. Conclusion Normal findings could be identified by fast-CMR without contrast agent. Fast CMR might also be a useful tool to identify different forms of CMP. Funding Acknowledgement Type of funding source: None

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