Significant Elevation in Potassium Concentration Surrounding Stimulated Excitable Cells Revealed by an Aptamer-Modified Nanowire Transistor

2021 ◽  
Author(s):  
Ankur Anand ◽  
Hui-Chiun Tseng ◽  
Hsu-Cheng Chiang ◽  
Wan-Hsuan Hsu ◽  
Yi-Fan Liao ◽  
...  
Keyword(s):  
Potassium Concentration ◽  
Significant Elevation ◽  
Excitable Cells ◽  
Nanowire Transistor

Release of Platelet Factor 4 in Vivo during Intravascular Coagulation and in Thrombotic States

1968 ◽  
Vol 19 (03/04) ◽  
pp. 578-583 ◽  
Author(s):  
R Farbiszewski ◽  
S Niewiarowski ◽  
K Worowski ◽  
B Lipiński
Keyword(s):  
Coronary Thrombosis ◽  
Laboratory Diagnosis ◽  
Tolerance Test ◽  
Platelet Factor 4 ◽  
Thrombin Time ◽  
Significant Elevation ◽  
Platelet Factor ◽  
Thrombotic Diseases ◽  
Disseminated Intravascular Clotting

SummaryPlatelet factor 4 released from platelets into the circulating blood was determined using both the heparin thrombin time and paracoagulation methods. It has been found that thrombin injected intravenously into rabbits releases large amounts of this factor. Infusion of plasmin does not release this factor and this finding may be of importance for the differential diagnosis between disseminated intravascular clotting and primary fibrinolysis. PF4 is not released during the hyper coagulable condition induced by HgCl2 intoxication. Only small amounts of this factor are released after contact factor infusion.A significant elevation of extraplatelet PF4 was found in 23 patients with fresh coronary thrombosis and in 9 patients with thrombophlebitis and thromboembolic complications.The significance of the above findings for the pathogenesis, treatment and laboratory diagnosis of thrombotic diseases with particular reference to heparin tolerance test is discussed.

Plasmalemmal transport of magnesium in excitable cells

2000 ◽  
Vol 5 (1) ◽  
pp. d866 ◽  
Author(s):  
Hector Rasgado-Flores
Keyword(s):  
Excitable Cells

Influence of Potassium Deprivation and Adrenalectomy on Potassium Concentration of the Myocardium

1955 ◽  
Vol 181 (3) ◽  
pp. 550-552 ◽  
Author(s):  
Shirley St. George ◽  
S. Charles Freed ◽  
Ray H. Rosenman ◽  
Sara Winderman
Keyword(s):  
Potassium Concentration ◽  
Potassium Deprivation

scholarly journals Effects of peroral alanine administration in lactating ewes with decreased availability of glucose

1997 ◽  
Vol 78 (5) ◽  
pp. 805-813 ◽  
Author(s):  
Kjell Holtenius ◽  
Paul Holtenius
Keyword(s):  
Fatty Acids ◽  
Plasma Level ◽  
Free Fatty Acids ◽  
Skeletal Muscles ◽  
Plasma Insulin ◽  
Glucose Oxidation ◽  
Negative Energy ◽  
Crossover Design ◽  
Metabolic Effects ◽  
Significant Elevation

The metabolic effects of a phlorizin-induced drainage of glucose were studied in six lactating ewes with or without peroral alanine drenches in a study of crossover design. Phlorizin gave rise to a small, but significant, elevation of plasma β-hydroxybutyrate. The plasma level of alanine decreased by about 30 % due to the phlorizin injections and alanine was negatively correlated to β-hydroxybutyrate. The plasma level of free fatty acids increased due to phlorizin. Plasma insulin and glucose concentrations were not significantly affected by phlorizin while glucagon level showed a small but significant increase. Peroral alanine drenches to phlorizin-treated ewes gave rise to a transitory elevation of alanine in plasma. The plasma level of free fatty acids was about 40 % lower in phlorizin-treated ewes receiving alanine and β-hydroxybutyrate tended to be lower (P < 0.08). We suggest that β-hydroxybutyrate, apart from its function as an oxidative fuel, might play an important role by limiting glucose oxidation and protein degradation in skeletal muscles during periods of negative energy balance in ruminants. Furthermore, it is suggested that alanine supplementation decreases lipolysis and ketogenesis in lactating ewes.

Effect of muscular exercise on plasma viscosity in correlation with postprandial triglyceridemia

1963 ◽  
Vol 18 (5) ◽  
pp. 991-993 ◽  
Author(s):  
Aarne Konttinen ◽  
Timo Somer
Keyword(s):  
Triglyceride Level ◽  
Exercise Group ◽  
Plasma Viscosity ◽  
The Other ◽  
Muscular Exercise ◽  
Significant Elevation ◽  
Total Proteins ◽  
Serum Triglycerides ◽  
Lower Triglyceride Level ◽  
Fat Meal

The correlation between postprandial triglyceridemia and plasma viscosity was studied in 45 healthy young men. One-half, 23, of them carried out a heavy march lasting 2 hr while the other half, 22, rested in bed. Serum triglycerides and plasma viscosity were determined before the fat meal and 4 and 6 hr postprandially. Serum total proteins and hematocrits were measured simultaneously. Despite significantly higher postprandial triglyceridemia in the resting group no rise was seen in plasma viscosity, whereas, in the exercise group with a lower triglyceride level a significant elevation took place in plasma viscosity. serum triglycerides Submitted on February 18, 1963

scholarly journals Volcano-Shaped Scanning Probe Microscopy Probe for Combined Force-Electrogram Recordings from Excitable Cells

Nano Letters ◽  
2020 ◽  
Vol 20 (6) ◽  
pp. 4520-4529
Author(s):  
B. X. E. Desbiolles ◽  
M. T. M Hannebelle ◽  
E. de Coulon ◽  
A. Bertsch ◽  
S. Rohr ◽  
...  
Keyword(s):  
Scanning Probe Microscopy ◽  
Scanning Probe ◽  
Excitable Cells ◽  
Probe Microscopy

scholarly journals Nanodevices Tend to Be Round

Micromachines ◽  
2021 ◽  
Vol 12 (3) ◽  
pp. 330
Author(s):  
Georges Pananakakis ◽  
Gérard Ghibaudo ◽  
Sorin Cristoloveanu
Keyword(s):  
Diffusion Process ◽  
Thermal Diffusion ◽  
Cross Section ◽  
Gate Voltage ◽  
Supportive Evidence ◽  
Inversion Mode ◽  
Nanowire Transistor ◽  
Junctionless Transistor ◽  
Simulation Results ◽  
Thermal Diffusion Process

Under several circumstances, a nanowire transistor with a square cross-section behaves as a circular. Taking the Gate-All-Around junctionless transistor as a primary example, we investigate the transition of the conductive region from square to circle-like. In this case, the metamorphosis is accentuated by smaller size, lower doping, and higher gate voltage. After defining the geometrical criterion for square-to-circle shift, simulation results are used to document the main consequences. This transition occurs naturally in nanowires thinner than 50 nm. The results are rather universal, and supportive evidence is gathered from inversion-mode Gate-All-Around (GAA) MOSFETs as well as from thermal diffusion process.

scholarly journals Roles of Microglial Ion Channel in Neurodegenerative Diseases

2021 ◽  
Vol 10 (6) ◽  
pp. 1239
Author(s):  
Alexandru Cojocaru ◽  
Emilia Burada ◽  
Adrian-Tudor Bălșeanu ◽  
Alexandru-Florian Deftu ◽  
Bogdan Cătălin ◽  
...  
Keyword(s):  
Ion Channels ◽  
Neurodegenerative Diseases ◽  
Excitable Cells ◽  
Proton Channels ◽  
Voltage Gated ◽  
Cellular Processes ◽  
Pathological Conditions ◽  
The Common ◽  
Transient Receptor ◽  
The Impact

As the average age and life expectancy increases, the incidence of both acute and chronic central nervous system (CNS) pathologies will increase. Understanding mechanisms underlying neuroinflammation as the common feature of any neurodegenerative pathology, we can exploit the pharmacology of cell specific ion channels to improve the outcome of many CNS diseases. As the main cellular player of neuroinflammation, microglia play a central role in this process. Although microglia are considered non-excitable cells, they express a variety of ion channels under both physiological and pathological conditions that seem to be involved in a plethora of cellular processes. Here, we discuss the impact of modulating microglia voltage-gated, potential transient receptor, chloride and proton channels on microglial proliferation, migration, and phagocytosis in neurodegenerative diseases.

scholarly journals Correcting hypokalaemia in a paediatric patient with Bartter syndrome through oral dose of potassium chloride intravenous solution

2021 ◽  
Vol 9 ◽  
pp. 2050313X2110197
Author(s):  
Salman Alasfour ◽  
Haya S Alfailakawi ◽  
Yousif A Shamsaldeen
Keyword(s):  
Paediatric Patient ◽  
Potassium Chloride ◽  
Serum Potassium ◽  
Nasogastric Tube ◽  
Potassium Concentration ◽  
Oral Route ◽  
Bartter Syndrome ◽  
Intravenous Route ◽  
Serum Potassium Concentration ◽  
Main Challenge

Bartter syndrome is a rare autosomal recessive disorder characterized by hypokalaemia. Hypokalaemia is defined as low serum potassium concentration ˂3.5 mmol/L, which may lead to arrhythmia and death if left untreated. The aim of this case report was to normalize serum potassium concentration without the need for intravenous intervention. A 5-month-old male of 2.7 kg body weight diagnosed with Bartter syndrome was admitted to the general paediatric ward with acute severe hypokalaemia and urinary tract infection. The main challenge was the inability to administer drugs through intravenous route due to compromised body size. Therefore, we shifted the route of administration to the nasogastric tube/oral route. A total of 2 mL of concentrated intravenous potassium chloride (4 mEq potassium) were dissolved in distilled water and administered through nasogastric tube. Serum potassium concentration was rapidly normalized, which culminated in patient discharge. In conclusion, shifting drug administration from intravenous to oral route in a paediatric patient with Bartter syndrome includes numerous advantages such as patient convenience, minimized risk of cannula-induced infection, and reduced nurse workload.

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