Mechanical and Electronic Cell–Chip Interaction of APTES-Functionalized Neuroelectronic Interfaces

2021 ◽  
Author(s):  
Nikolaus R. Wolf ◽  
Pratika Rai ◽  
Manuel Glass ◽  
Frano Milos ◽  
Vanessa Maybeck ◽  
...  
Keyword(s):  
Cell Chip

scholarly journals Simple Fabrication of Adipocyte Cell Chip Using Micropatterning

2016 ◽  
Vol 54 (2) ◽  
pp. 223-228 ◽  
Author(s):  
Gi Yong Kim ◽  
Heon-Ho Jeong ◽  
Chang-Soo Lee ◽  
Changhyun Roh
Keyword(s):  
Cell Chip ◽  
Adipocyte Cell

Nanoscale fabrication of a peptide layer in cell chip to detect effects of environmental toxins on HEK293 cells

2010 ◽  
Vol 32 (12) ◽  
pp. 1797-1802 ◽  
Author(s):  
Md. Abdul Kafi ◽  
Tae-Hyung Kim ◽  
Ajay Kumar Yagati ◽  
Hyuncheol Kim ◽  
Jeong-Woo Choi
Keyword(s):  
Environmental Toxins ◽  
Hek293 Cells ◽  
Cell Chip ◽  
Nanoscale Fabrication

scholarly journals Gold Nanowires/Fibrin Nanostructure as Microfluidics Platforms for Enhancing Stem Cell Differentiation: Bio-AFM Study

Micromachines ◽  
2019 ◽  
Vol 11 (1) ◽  
pp. 50 ◽  
Author(s):  
Hashemzadeh ◽  
Allahverdi ◽  
Ghorbani ◽  
Soleymani ◽  
Kocsis ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Differentiation ◽  
Stem Cell Differentiation ◽  
Physical Parameters ◽  
Gold Nanowires ◽  
Matrix Elasticity ◽  
Cell Chip ◽  
Chip Technology ◽  
Wide Range ◽  
Organ On A Chip

Organ-on-a-chip technology has gained great interest in recent years given its ability to control the spatio-temporal microenvironments of cells and tissues precisely. While physical parameters of the respective niche such as microchannel network sizes, geometric features, flow rates, and shear forces, as well as oxygen tension and concentration gradients, have been optimized for stem cell cultures, little has been done to improve cell-matrix interactions in microphysiological systems. Specifically, detailed research on the effect of matrix elasticity and extracellular matrix (ECM) nanotopography on stem cell differentiation are still in its infancy, an aspect that is known to alter a stem cell’s fate. Although a wide range of hydrogels such as gelatin, collagen, fibrin, and others are available for stem cell chip cultivations, only a limited number of elasticities are generally employed. Matrix elasticity and the corresponding nanotopography are key factors that guide stem cell differentiation. Given this, we investigated the addition of gold nanowires into hydrogels to create a tunable biointerface that could be readily integrated into any organ-on-a-chip and cell chip system. In the presented work, we investigated the matrix elasticity (Young’s modulus, stiffness, adhesive force, and roughness) and nanotopography of gold nanowire loaded onto fibrin hydrogels using the bio-AFM (atomic force microscopy) method. Additionally, we investigated the capacity of human amniotic mesenchymal stem cells (hAMSCs) to differentiate into osteo- and chondrogenic lineages. Our results demonstrated that nanogold structured-hydrogels promoted differentiation of hAMSCs as shown by a significant increase in Collagen I and II production. Additionally, there was enhanced calcium mineralization activity and proteoglycans formation after a cultivation period of two weeks within microfluidic devices.

Abstract 2182: Differential transfection on a cell chip for high throughput analysis of paracrine gene effects in angiogenesis and tumor invasion

2010 ◽  
Author(s):  
Elisabeth Kuhn ◽  
Elisabeth Naschberger ◽  
Andreas Konrad ◽  
Roland S. Croner ◽  
Helmut Münstedt ◽  
...  
Keyword(s):  
High Throughput ◽  
Tumor Invasion ◽  
High Throughput Analysis ◽  
Gene Effects ◽  
Throughput Analysis ◽  
Cell Chip ◽  
A Cell

Micro-PIV Measurement on Transient Flows in Pneumatic MEMS Device for Cell Trapping

2011 ◽  
Author(s):  
Hyun Dong Kim ◽  
Kyung Chun Kim
Keyword(s):  
Flow Characteristics ◽  
Operational Conditions ◽  
Cell Trapping ◽  
Transient Flows ◽  
Micro Piv ◽  
Cell Chip ◽  
Piv Measurement ◽  
Measurement Results ◽  
Equilibrium Region ◽  
Pneumatic Vibrator

This paper presents a micro-PIV measurement for investigation of flow characteristics in a micro chamber for trapping of a live cell. The micro cell chip consisting of pneumatic vibrator arrays and a trap chamber was fabricated through a replica molding technology with a SU-8 mold and Polydimethylsiloxane (PDMS) polymer. The single cell in the trap chamber was manipulated and trapped in the equilibrium region by exploiting the geometrical symmetry of the vibrators. The x-axial velocity of the viscous fluid induced by the deformation of the flexible diaphragms was eliminated or minimized at the center of vibrators. From the measurement results, the proper operational conditions of the vibrators were determined and it is also verified that the particle can be actively manipulated and trapped as desired.

scholarly journals Metallic Nanoparticle-Based Optical Cell Chip for Nondestructive Monitoring of Intra/Extracellular Signals

Pharmaceutics ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 50
Author(s):  
Sang-Nam Lee ◽  
Jin-Ha Choi ◽  
Hyeon-Yeol Cho ◽  
Jeong-Woo Choi
Keyword(s):  
Metallic Nanoparticles ◽  
High Sensitivity ◽  
Surface Enhanced Raman Spectroscopy ◽  
Localized Surface Plasmon ◽  
Nondestructive Monitoring ◽  
Metallic Nanoparticle ◽  
Optical Cell ◽  
Cell Chip ◽  
The Status ◽  
Sensitivity And Selectivity

The biosensing platform is noteworthy for high sensitivity and precise detection of target analytes, which are related to the status of cells or specific diseases. The modification of the transducers with metallic nanoparticles (MNPs) has attracted attention owing to excellent features such as improved sensitivity and selectivity. Moreover, the incorporation of MNPs into biosensing systems may increase the speed and the capability of the biosensors. In this review, we introduce the current progress of the developed cell-based biosensors, cell chip, based on the unique physiochemical features of MNPs. Mainly, we focus on optical intra/extracellular biosensing methods, including fluorescence, localized surface plasmon resonance (LSPR), and surface-enhanced Raman spectroscopy (SERS) based on the coupling of MNPs. We believe that the topics discussed here are useful and able to provide a guideline in the development of new MNP-based cell chip platforms for pharmaceutical applications such as drug screening and toxicological tests in the near future.

Electrochemical Detection of Pathogen Infection Using Cell Chip

2006 ◽  
Vol 129 (1-3) ◽  
pp. 37-42 ◽  
Author(s):  
J. W. Choi ◽  
W. Lee ◽  
D. B. Lee ◽  
C. H. Park ◽  
J. S. Kim ◽  
...  
Keyword(s):  
Electrochemical Detection ◽  
Pathogen Infection ◽  
Cell Chip
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